公开(公告)号：US12139723B2

公开(公告)日：2024-11-12

申请号：US17238760

申请日：2021-04-23

Applicant: University of Georgia Research Foundation, Inc. ,  Aruna Bio, Inc.

Inventor： Steven L. Stice ,  Robin Lynn Webb ,  Tracey A. Stice

IPC: A61K35/12 ,  A61K9/51 ,  A61K35/30 ,  A61K35/545 ,  A61P25/28 ,  C12N5/079 ,  C12N5/0793 ,  C12N5/0797 ,  A61K9/50 ,  G01N33/569

Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative disease.

公开(公告)号：US12139517B2

公开(公告)日：2024-11-12

申请号：US16856774

申请日：2020-04-23

Applicant: Sangamo Therapeutics, Inc.

Inventor： Joseph F. Nabhan ,  Amrutha Pattamatta ,  Mohammad Samie

IPC: C07K14/435 ,  A61P25/00 ,  A61P25/28 ,  C12N15/86 ,  A61K38/00 ,  A61K48/00

Abstract: The present disclosure provides compositions and methods for modulating transcription of mutant C9orf72 gene alleles in patients in need thereof, including patients having a C9orf72-related disease such as amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD).

公开(公告)号：US12139505B2

公开(公告)日：2024-11-12

申请号：US17140789

申请日：2021-01-04

Applicant: The University of Toledo ,  Washington State University

Inventor： Kenneth Hensley ,  Travis Denton

IPC: C07F9/6544 ,  A61P25/16 ,  A61P25/28 ,  A61P35/00

Abstract: Lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P), other lanthionine ketimine, lanthionine ketimine phosphonate, and lanthionine ketimine ester derivatives, methods of making and using the same, and methods of treatments are described.

公开(公告)号：US12138300B2

公开(公告)日：2024-11-12

申请号：US17272393

申请日：2019-08-29

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Jerry Silver ,  Yu Luo ,  Fucheng Luo

IPC: A61K38/46 ,  A61K9/00 ,  A61P9/10 ,  A61P25/28

Abstract: A method of promoting compensatory plasticity of spared neural cells after a neural injury includes contacting the spared neural cells with an effective amount of a therapeutic agent comprising a therapeutic peptide, wherein the therapeutic peptide comprises an amino acid sequence with at least 70% identity to SEQ ID NO:32.

公开(公告)号：US12138238B2

公开(公告)日：2024-11-12

申请号：US18359271

申请日：2023-07-26

Applicant: MBI Distributing

Inventor： Ned L. Jensen

IPC: A61K31/22 ,  A61K9/127 ,  A61K31/4045 ,  A61K47/10 ,  A61K47/14 ,  A61K47/24 ,  A61P15/00 ,  A61P25/06 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  C07C231/14

Abstract: The present invention is directed to compositions comprising N-Acetyl Methyl GABA, methods of preparing N-Acetyl Methyl GABA and compositions including N-Acetyl Methyl GABA, and methods of using N-Acetyl Methyl GABA for instance to improve sleep and control anxiety.

公开(公告)号：US20240360443A1

公开(公告)日：2024-10-31

申请号：US18609277

申请日：2024-03-19

Applicant: Dystrogen Gene Therapies Inc.

Inventor： Marta OLEJNICZAK ,  Anna KOTOWSKA-ZIMMER ,  Marianna PEWINSKA ,  Paul LEWICKI ,  Krzysztof SIEMIONOW

IPC: C12N15/113 ,  A61P25/28 ,  C12N15/86

CPC classification number: C12N15/113 ,  A61P25/28 ,  C12N15/86 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2750/14143

Abstract: A nucleic acid molecule composed of a duplex and loop, in which one of the duplex strands, the guide strand, comprises a sequence chosen from SEQ ID NO. 1-4, and the other strand of the duplex, the passenger strand, is at least 80% complementary to the guide strand, wherein the nucleic acid molecule forms a hairpin structure in a cell.

公开(公告)号：US20240360164A1

公开(公告)日：2024-10-31

申请号：US18411480

申请日：2024-01-12

Applicant: Cyclerion Therapeutics, Inc.

Inventor： James Edward Sheppeck ,  Paul Allan Renhowe ,  Ara Mermerian ,  Timothy Claude Barden ,  Glen Robert Rennie ,  Rajesh R. Iyengar ,  Takashi Nakai

IPC: C07F9/6558 ,  A61P3/00 ,  A61P9/10 ,  A61P9/12 ,  A61P25/28

CPC classification number: C07F9/65583 ,  A61P3/00 ,  A61P9/10 ,  A61P9/12 ,  A61P25/28 ,  C07F9/65586

Abstract: The present patent application discloses the compounds according to Formula I shown below, or pharmaceutically acceptable salts thereof, wherein JB, n, R1, R2, R3, R4, R5, m and X as defined herein.

公开(公告)号：US20240360127A1

公开(公告)日：2024-10-31

申请号：US18763210

申请日：2024-07-03

Applicant: Ventus Therapeutics U.S., Inc.

Inventor： Stéphane DORICH ,  Amandine CHEFSON

IPC: C07D471/04 ,  A61P25/28

CPC classification number: C07D471/04 ,  A61P25/28

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein.

公开(公告)号：US12128108B2

公开(公告)日：2024-10-29

申请号：US17979450

申请日：2022-11-02

Applicant: Aihol Corporation

Inventor： Szu-Yuan Lee ,  Ping-Shan Lai ,  Chih-An Lin

IPC: A61K47/61 ,  A61K31/565 ,  A61K31/566 ,  A61K31/568 ,  A61K31/573 ,  A61K47/54 ,  A61P25/28

CPC classification number: A61K47/61 ,  A61K31/565 ,  A61K31/566 ,  A61K31/568 ,  A61K31/573 ,  A61K47/542 ,  A61P25/28

Abstract: Disclosed herein is a method of using a hyaluronan conjugate, which includes a hyaluronic acid (HA), a sex hormone, and a linker for coupling one of the disaccharide units of the HA and the sex hormone. The hyaluronan conjugates are used in treating neurodegenerative diseases.

公开(公告)号：US12128031B2

公开(公告)日：2024-10-29

申请号：US18206559

申请日：2023-06-06

Applicant: HB Biotech, Inc.

Inventor： Alon Seifan

IPC: A61K31/4184 ,  A61K31/277 ,  A61K33/08 ,  A61K45/06 ,  A61P25/22 ,  A61P25/28

CPC classification number: A61K31/4184 ,  A61K31/277 ,  A61K33/08 ,  A61K45/06 ,  A61P25/22 ,  A61P25/28

Abstract: As described below, the present invention features compositions and methods for treating brain and/or behavioral health disorders and their associated symptoms.