公开(公告)号：US11071617B2

公开(公告)日：2021-07-27

申请号：US17063924

申请日：2020-10-06

Applicant: Washington University

Inventor： Matthew R. MacEwan ,  Jingwei Xie ,  Zack Ray ,  Younan Xia

IPC: A61F2/00 ,  A61F2/02 ,  B29C48/05 ,  B29C48/14 ,  A61L15/22 ,  A61L15/42 ,  A61L27/14 ,  A61L27/50 ,  D01D5/00 ,  D04H1/728 ,  D04H3/016 ,  D04H3/073 ,  A61F2/10 ,  C12M1/12

Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.

公开(公告)号：US20210213157A1

公开(公告)日：2021-07-15

申请号：US16738294

申请日：2020-01-09

Applicant: Ethicon, Inc.

Inventor： Ashley DeAnglis ,  Doug Johns ,  Guanghui Zhang ,  Wilai Kosol

IPC: A61L15/32 ,  A61L15/42 ,  A61L15/22 ,  A61L24/00

Abstract: The present invention is directed to hemostatic sealants having a compressed porous substrate, an electrophilic group containing component that is not gelatin or collagen, a nucleophilic group containing component, and a buffering agent. The present invention also relates to method for manufacture and use of such sealants to seal and/or achieve hemostasis.

公开(公告)号：US20210205491A1

公开(公告)日：2021-07-08

申请号：US16067820

申请日：2017-01-18

Applicant: WUHAN UNIVERSITY OF TECHNOLOGY

Inventor： Yingchao HAN ,  Gang ZHAO ,  Honglian DAI

IPC: A61L15/22 ,  A61L15/18 ,  A61L15/44 ,  A61F13/00

Abstract: The present invention relates to a polyvinyl alcohol/sodium alginate/hydroxyapatite composite fibrous membrane, and a preparation method and an application thereof. The preparation method of the composite fibrous membrane includes the following steps: firstly, reacting a diammonium hydrogen phosphate with a calcium nitrate to prepare a hydroxyapatite, and performing ultrasonic dispersion on the hydroxyapatite with a sodium alginate to form a stable hydroxyapatite suspension; separately preparing a sodium alginate solution of which the mass fraction is 2% and a polyvinyl alcohol solution of which the mass fraction is 18% using the above stable hydroxyapatite suspension; and finally, proportionally and uniformly mixing the two solutions, and performing electrospinning.

公开(公告)号：US11052177B2

公开(公告)日：2021-07-06

申请号：US14479536

申请日：2014-09-08

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Inventor： Hyun-Su Lee ,  David M. Eckmann ,  Russell Composto

IPC: A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L15/22 ,  A61L27/34 ,  A61L31/16 ,  A61L15/46 ,  A61L27/54

Abstract: The invention provides compositions comprising a plurality of polymer layers for preventing or inhibiting microbial infections. Specifically, the invention provides a combination of a cationic polymer layer that resists adhesion of a microbe to its surface and an anionic polymer layer that releases a cationic anti-microbial agent in response to a change in pH or electrostatic balance.

公开(公告)号：US11045575B2

公开(公告)日：2021-06-29

申请号：US16898990

申请日：2020-06-11

Applicant: Yoshiyuki Koyama

Inventor： Yoshiyuki Koyama ,  Tomoko Ito

IPC: A61L26/00 ,  A61L15/60 ,  A61L15/22 ,  A61L31/14 ,  A61L31/04 ,  C08L39/06

Abstract: A soft film, a sponge, or a sheet in the dried state is provided, which is capable of forming a hydrogel absorbing water or blood. The film is obtainable by preparing a film-state material in the dried state from either a solution of poly(acrylic acid) or a solution of polyvinylpyrrolidone, and bringing the film-state material into contact with the other remaining solution, and then drying or freeze-drying it.

公开(公告)号：US11045364B2

公开(公告)日：2021-06-29

申请号：US15799755

申请日：2017-10-31

Applicant: TIETEX INTERNATIONAL LTD.

Inventor： Martin Wildeman

IPC: A61F13/62 ,  D04B21/16 ,  A61F13/56 ,  D04B21/02 ,  A61L15/22

Abstract: A composite loop face fabric which incorporates a multi-bar stitch-bonded construction and related fastening system. A yarn system forms an arrangement of surface loops extending in stitched relation through a composite nonwoven stitching substrate incorporating at least one layer of a cellulose tissue disposed in surface covering relation to at least one layer of a nonwoven support material of polymeric fiber. Multiple layers of cellulose tissue and nonwoven support material may be used if desired.

公开(公告)号：US20210169708A1

公开(公告)日：2021-06-10

申请号：US17108212

申请日：2020-12-01

Applicant: The Procter & Gamble Company

Inventor： Ray Dennis DRIA ,  Urmish Popatlal DALAL ,  Kevin Ronald KANYA ,  Kelyn Anne ARORA ,  Stephanie Niezgoda MOSS ,  Shirdish POONDRU ,  Timothy Ian MULLANE ,  Nathan Ray WHITELY ,  John Lee HAMMONS

IPC: A61F13/49 ,  A61F13/514 ,  A61F13/15 ,  A61L15/22 ,  A61L15/24 ,  A61L15/60 ,  D04H3/007 ,  D04H3/018 ,  D04H3/16

Abstract: An absorbent article includes a topsheet, backsheet and absorbent core disposed between a portion of the topsheet and the backsheet, and an elastomeric laminate. The elastomeric laminate includes a first nonwoven, a second nonwoven, and a preactivated film positioned between the first and second nonwoven; and a plurality of ultrasonic bonds. The absorbent core comprises absorbent material and at least one channel, wherein the at least one channel is substantially free of absorbent material.

公开(公告)号：US11027039B2

公开(公告)日：2021-06-08

申请号：US15905813

申请日：2018-02-26

Applicant: DSG TECHNOLOGY HOLDINGS LTD.

Inventor： Eugenio Varona ,  Andrew Wright ,  Dennis Smid

IPC: A61L15/60 ,  B01J20/28 ,  B01J20/32 ,  B01J20/24 ,  B01J20/26 ,  A61L15/22 ,  A61F13/531 ,  B01J20/30 ,  A61F13/53

Abstract: A fiber-SAP particle includes a superabsorbent core particle (SAP core particle) and a plurality of fibers attached to the SAP core particle and extending therefrom. The fiber-SAP particles may be formed in a fluidized bed chamber using a spray drying process. The fiber-SAP particles may be incorporated into absorbent cores and articles, such as in disposable diapers.

公开(公告)号：US11020427B2

公开(公告)日：2021-06-01

申请号：US16851862

申请日：2020-04-17

Applicant: JFE MINERAL COMPANY, LTD.

Inventor： Etsurou Udagawa ,  Yuko Echizenya ,  Chisaki Miura ,  Yoshimi Nakata ,  Osamu Yamamoto

IPC: A61K33/30 ,  A61K8/27 ,  A61Q19/00 ,  A61L15/22 ,  A61P17/02

Abstract: Provided is a low-cost, easy-to-handle, effective therapeutic agent for wounds that is a therapeutic agent for skin wounds or rough skin that includes at least one selected from the group consisting of zinc chloride, zinc hydroxide, and zinc oxide and may include a pharmaceutically acceptable carrier.

公开(公告)号：US20210100991A1

公开(公告)日：2021-04-08

申请号：US17024472

申请日：2020-09-17

Applicant: Biointraface Inc.

Inventor： John D. Jarrell

IPC: A61M35/00 ,  A61J1/06 ,  A61J1/20 ,  A61M25/00 ,  A61F2/28 ,  A61B17/84 ,  A61B17/86 ,  A61B17/80 ,  A61B17/60 ,  A61F2/30 ,  A61F13/00 ,  A61M16/04 ,  A61B46/00 ,  A61K47/02 ,  A61K31/47 ,  A61K31/085 ,  A61K31/4164 ,  A61K31/79 ,  A61K31/325 ,  A61K31/201 ,  A61K38/12 ,  A61K31/65 ,  A61K31/702 ,  A61K31/327 ,  A61K31/05 ,  A61K31/60 ,  A61K33/04 ,  A61K6/69 ,  A61L29/10 ,  A61L31/10 ,  A61L15/22 ,  A61L27/34 ,  A61L27/54

Abstract: A dose applicator for preparing a mixture at a point of use includes a housing defining an interior and an opening. First and second ampoules are contained in the interior, wherein the first ampoule contains a first component and the second ampoule contains a second component comprising one or more antifungal agent. An applicator tip is secured in the opening so that when the first and second ampoules are broken, the first and second components mix to form the mixture and the mixture can egress from the application tip.