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    Compositions for conjugated estrogens and associated methods
    52.
    发明授权
    Compositions for conjugated estrogens and associated methods 有权
    共轭雌激素和相关方法的组合物

    公开(公告)号：US07303763B2

    公开(公告)日：2007-12-04

    申请号：US10668104

    申请日：2003-09-22

    申请人： Thomas Ho

    发明人： Thomas Ho

    IPC分类号： A61K9/36 ,  A61K9/28 ,  A61K9/30 ,  A61K9/32

    CPC分类号： A61K9/2826 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2846 ,  A61K31/56 ,  A61K31/565

    摘要： Oral conjugated estrogen formulations are disclosed and described. In one aspect, the oral formulation may be a tablet having a core and one or more coatings thereon. In addition to conjugated estrogen ingredients, the core may include one or more organic excipients and one or more inorganic excipients. In one aspect, the organic excipients may include less than about 20% w/w of a cellulose ingredient, and less than about 50% w/w of a sugar ingredient. In another aspect, the inorganic excipients may include less than about 10% w/w of a calcium phosphate tribasic ingredient. In yet another aspect, the formulation does not crack when stored at about 40° C. and about 75% relative humidity for about 2 months.

    摘要翻译： 公开和描述了口服共轭雌激素制剂。 一方面，口服制剂可以是其上具有核心和一种或多种涂层的片剂。 除了共轭雌激素成分之外，核心可以包括一种或多种有机赋形剂和一种或多种无机赋形剂。 在一个方面，有机赋形剂可以包括小于约20％w / w的纤维素成分和小于约50％w / w的糖成分。 另一方面，无机赋形剂可以包含小于约10％w / w的磷酸三钙成分。 在另一方面，当在约40℃和约75％相对湿度下储存约2个月时，制剂不会破裂。

    Ready Mix Flavored Film Coating Systems
    53.
    发明申请
    Ready Mix Flavored Film Coating Systems 审中-公开
    准备混合调味薄膜涂层系统

    公开(公告)号：US20070272121A1

    公开(公告)日：2007-11-29

    申请号：US10590565

    申请日：2004-02-28

    申请人： Suresh Pareek ,  Ashok Mohanty

    发明人： Suresh Pareek ,  Ashok Mohanty

    IPC分类号： A61K9/36

    CPC分类号： A61K9/2866

    摘要： The invention comprises a preparation of a ready mix flavored composition, which when reconstituted with water/solvent gives film coatings that are flavored, so that the thin film coating on solid oral dosage forms containing unpleasant tasting ingredients, masks the bitter taste of the medicaments in the oral solid dosage forms. The flavored coating of the invention is comprised of a film—forming substances such as a hydroxy propyl methylcellulose and other polymers and a flavoring agent.

    摘要翻译： 本发明包括一种现成混合调味组合物的制备物，当用水/溶剂重构时，该组合物产生调味的薄膜包衣，使得含有令人不快的品尝成分的固体口服剂型上的薄膜包衣掩盖了药物的苦味 口服固体剂型。 本发明的调味涂层由成膜物质如羟基丙基甲基纤维素和其它聚合物和调味剂组成。

    Rapidly disintegrable tablets
    54.
    发明授权
    Rapidly disintegrable tablets 有权
    快速崩解片

    公开(公告)号：US07282217B1

    公开(公告)日：2007-10-16

    申请号：US10929856

    申请日：2004-08-30

    申请人： Michael N. Grimshaw ,  Donald J. Barbieri ,  Louise M. Vizzini ,  Steve F. Marsh

    发明人： Michael N. Grimshaw ,  Donald J. Barbieri ,  Louise M. Vizzini ,  Steve F. Marsh

    IPC分类号： A61K9/36 ,  A61K9/26 ,  A61K47/00

    CPC分类号： A61K9/2018 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/2095

    摘要： The invention provides a rapidly disintegrating tablet comprising an active ingredient, a water soluble, directly compressible carbohydrate, and a water soluble, directly compressible filler. Also provided is a method of producing a rapidly disintegrating tablet, which method comprises wet granulating a mixture comprising a directly compressible, water soluble carbohydrate, a directly compressible, water insoluble filler, a beneficial ingredient, and a solvent, and compressing the granulate to produce the tablet.

    摘要翻译： 本发明提供了包含活性成分，水溶性，可直接压缩的碳水化合物和水溶性直接可压缩填料的快速崩解片剂。 还提供了一种生产快速崩解片剂的方法，该方法包括将包含直接可压缩的水溶性碳水化合物，直接可压缩的水不溶性填料，有益成分和溶剂的混合物湿式造粒，并压制该颗粒以产生 平板电脑

    Enrobed core
    57.
    发明授权
    Enrobed core 有权
    核心核心

    公开(公告)号：US07169450B2

    公开(公告)日：2007-01-30

    申请号：US10146471

    申请日：2002-05-15

    申请人： Frank J. Bunick

    发明人： Frank J. Bunick

    IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K9/30 ,  A61K9/36 ,  A61K9/38 ,  A61K9/40 ,  B05D5/06 ,  B05D1/00 ,  B01J13/22

    CPC分类号： A61K9/209 ,  A61J3/005 ,  A61K9/2072 ,  A61K9/2893 ,  B30B11/16 ,  B30B11/34 ,  Y10T428/13 ,  Y10T428/1352 ,  Y10T428/2933 ,  Y10T428/2935

    摘要： An enrobed a core, such as a tablet core, that has a coating made of one or more patterned films each having portions that are visually distinct (e.g., differently colored) from one another and having a transition line segment between these visually distinct portions. At least a portion of an outer surface of the core is covered with the film or films, such that the transition line segments form a substantially continuous transition line on the coating and a film seam is formed which is different from the transition line. Where the patterned films are bi-colored, the resulting enrobed core can be bi-colored, or the resulting enrobed core can have a coating with at least four visually distinct portions alternately arranged thereon, thereby forming a “checkerboard” pattern on the coating. In either case, the film seam of the coating is different from the transition line of the coating.

    摘要翻译： 具有由一个或多个图案化膜构成的涂层的核心，例如片芯，其具有各自具有视觉上彼此不同（例如不同颜色）的部分，并且在这些视觉上不同的部分之间具有过渡线段。 芯的外表面的至少一部分被膜或膜覆盖，使得过渡线段在涂层上形成基本上连续的过渡线，形成与过渡线不同的膜接缝。 在图案化的膜是双色的情况下，所得到的被包裹的芯可以是双色的，或者所得到的被包埋的芯可以具有交替地布置在其上的至少四个视觉上不同部分的涂层，从而在涂层上形成“棋盘”图案。 在任一种情况下，涂层的胶层不同于涂层的过渡线。

    Solid preparations for oral use
    60.
    发明授权
    Solid preparations for oral use 失效
    用于口服使用的固体制剂

    公开(公告)号：US06949259B1

    公开(公告)日：2005-09-27

    申请号：US10111418

    申请日：2000-11-10

    申请人： Toshinori Ohyama ,  Masaru Imamizu

    发明人： Toshinori Ohyama ,  Masaru Imamizu

    IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K9/36 ,  A61K31/426 ,  A61P3/10 ,  C07D277/34

    CPC分类号： A61K9/2866 ,  A61K9/20 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/282 ,  A61K31/426 ,  C07D277/34

    摘要： Solid preparations for oral use for facilitating the administration in a small dose of KRP-297, which is a ligand common to peroxisome proliferator-activated receptors PPAR α and PPAR γ (i.e., nuclear receptors) and has an effect of ameliorating insulin resistance, which contain the drug ingredient in a uniform content and can be easily and quantitatively taken. By preparing solid preparations for oral use composed of a trace amount of the drug ingredient together with pharmaceutical carriers, it is possible to provide tablets which contain the drug component in a uniform content and can be easily and quantitatively taken.

    摘要翻译： 用于口服使用的固体制剂有助于小剂量KRP-297的施用，KRP-297是过氧化物酶体增殖物激活受体PPARα和PPARγ（即核受体）常见的配体，具有改善胰岛素抵抗的作用， 含有均匀含量的药物成分，并且可以容易且定量地服用。 通过制备由药物成分与药物载体组成的口服用固体制剂，可以容易且定量地提供含有药物成分的片剂，其含有均匀的含量。