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56 条记录 (耗时 0.015 秒)

    MANUFACTURE OF TABLET HAVING IMMEDIATE RELEASE REGION AND SUSTAINED RELEASE REGION
    2.
    发明申请
    MANUFACTURE OF TABLET HAVING IMMEDIATE RELEASE REGION AND SUSTAINED RELEASE REGION 有权
    具有立即释放区域和持续发布区域的片剂的制造

    公开(公告)号：US20110070304A1

    公开(公告)日：2011-03-24

    申请号：US12887560

    申请日：2010-09-22

    申请人： Leo B. Kriksunov ,  Harry S. Sowden ,  Joseph R. Luber ,  Frank J. Bunick

    发明人： Leo B. Kriksunov ,  Harry S. Sowden ,  Joseph R. Luber ,  Frank J. Bunick

    IPC分类号： A61K9/22 ,  A61P29/00 ,  B29C35/02 ,  B29C43/02 ,  B29C35/08

    CPC分类号： A61K9/209 ,  A61J3/10 ,  A61J2200/42 ,  A61K9/2013 ,  A61K9/2095 ,  B29C43/36 ,  B29C2043/3618

    摘要： In one aspect, the present invention features a process for making a tablet including a pharmaceutically active agent wherein the tablet has both an immediate release region and a modified release region. The method includes the steps of: (a) forming a tablet shape including a powder blend containing a pharmaceutically active agent and a thermally-sensitive material; and (b) applying energy in different amounts to different regions of the tablet shape to form the tablet in a manner such that: (i) a first region of the tablet shape is exposed to said energy for a sufficient period of time to melt the thermally-sensitive material within the first region to form said modified release region of said tablet; and (ii) a second region of said tablet shape is not so exposed to the energy such that said second region forms the immediate release region of said tablet.

    摘要翻译： 在一个方面，本发明的特征在于制备包含药物活性剂的片剂的方法，其中所述片剂具有即释释区域和修饰释放区域。 该方法包括以下步骤：（a）形成包含含有药物活性剂和热敏材料的粉末混合物的片剂形式; 和（b）将不同量的能量施加到片剂形状的不同区域以形成片剂，使得：（i）片剂形状的第一区域暴露于所述能量足够的时间以熔化 在第一区域内的热敏材料形成所述片剂的所述改性释放区域; 和（ii）所述片剂形状的第二区域不会暴露于能量，使得所述第二区域形成所述片剂的立即释放区域。

    NON-HOMOGENOUS DOSAGE FORM COATINGS
    4.
    发明申请
    NON-HOMOGENOUS DOSAGE FORM COATINGS 审中-公开
    非均质剂型涂料

    公开(公告)号：US20070231389A1

    公开(公告)日：2007-10-04

    申请号：US11691839

    申请日：2007-03-27

    申请人： Frank J. Bunick ,  Jen-Chi Chen

    发明人： Frank J. Bunick ,  Jen-Chi Chen

    IPC分类号： A61K9/24 ,  A61K9/50 ,  A61K9/16

    CPC分类号： A61K9/2873 ,  A61K9/1617 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/282 ,  A61K9/286 ,  A61K9/2893 ,  A61K9/5015 ,  A61K9/5042 ,  A61K9/5089

    摘要： The present invention is directed to liquid coating compositions and dosage forms having a continuous shell portion of a first composition and at least one discontinuous shell portion that is compositionally different located within the continuous shell portion. The present invention also provides a process for preparing a dosage form, which comprises coating a core with a continuous shell portion having a first composition and at least one discontinuous shell portion that is compositionally different located within the continuous portion, and then cooling the coated core. The coating compositions are particularly suited for forming shell coatings on solid pharmaceutical dosage forms.

    摘要翻译： 本发明涉及具有第一组合物的连续壳部分和在组成上不同于位于连续壳部分内的至少一个不连续壳部分的液体涂料组合物和剂型。 本发明还提供了一种制备剂型的方法，该方法包括用具有第一组合物的连续壳部分和至少一个在连续部分内组成不同的不连续壳部分涂覆芯，然后冷却涂层芯 。 涂料组合物特别适用于在固体药物剂型上形成壳涂层。

    Purification of polydextrose by reverse osmosis
    7.
    发明授权
    Purification of polydextrose by reverse osmosis 失效
    通过反渗透纯化聚右旋糖

    公开(公告)号：US4956458A

    公开(公告)日：1990-09-11

    申请号：US193961

    申请日：1988-05-13

    申请人： Shiuh J. Luo ,  Frank J. Bunick ,  Robert H. Graf

    发明人： Shiuh J. Luo ,  Frank J. Bunick ,  Robert H. Graf

    IPC分类号： A23L1/09 ,  A23L1/29 ,  C08B37/00 ,  C08B37/02

    CPC分类号： C08B37/0003

    摘要： The present invention is a process for purifying polydextrose to remove manufacturing contaminants such as glucose, sorbitol, citric acid, oligomers, 1,6-anhydroglucose, 5-hydroxymethylfurfural and other low molecular weight constituents by reverse osmosis wherein an aqueous solution of polydextrose is filtered by pressing it tangentially over a porous membrane at high pressure. This invention process produces a purified polydextrose with the 1,6-anhydroglucose content therein reduced to less than about 0.2% (W/W) and a reduction in the 5-hydroxymethylfurfural content to below detectable levels or loss than about 0.01% (W/W), thereby virtually eliminating any bitter taste or musty off-flavor.