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56 条记录 (耗时 0.03 秒)

    Purification of polydextrose by reverse osmosis
    1.
    发明授权
    Purification of polydextrose by reverse osmosis 失效
    通过反渗透纯化聚右旋糖

    公开(公告)号：US4956458A

    公开(公告)日：1990-09-11

    申请号：US193961

    申请日：1988-05-13

    申请人： Shiuh J. Luo ,  Frank J. Bunick ,  Robert H. Graf

    发明人： Shiuh J. Luo ,  Frank J. Bunick ,  Robert H. Graf

    IPC分类号： A23L1/09 ,  A23L1/29 ,  C08B37/00 ,  C08B37/02

    CPC分类号： C08B37/0003

    摘要： The present invention is a process for purifying polydextrose to remove manufacturing contaminants such as glucose, sorbitol, citric acid, oligomers, 1,6-anhydroglucose, 5-hydroxymethylfurfural and other low molecular weight constituents by reverse osmosis wherein an aqueous solution of polydextrose is filtered by pressing it tangentially over a porous membrane at high pressure. This invention process produces a purified polydextrose with the 1,6-anhydroglucose content therein reduced to less than about 0.2% (W/W) and a reduction in the 5-hydroxymethylfurfural content to below detectable levels or loss than about 0.01% (W/W), thereby virtually eliminating any bitter taste or musty off-flavor.

    Polydextrose compositions
    4.
    发明授权
    Polydextrose compositions 失效
    POLYDEXTROSE组合物

    公开(公告)号：US5091015A

    公开(公告)日：1992-02-25

    申请号：US527224

    申请日：1990-05-22

    申请人： Frank J. Bunick ,  Shiuh J. Luo

    发明人： Frank J. Bunick ,  Shiuh J. Luo

    IPC分类号： A23L1/015 ,  A23L1/03 ,  A23L1/308 ,  C07H1/06 ,  C08B37/00

    CPC分类号： C08B37/0009 ,  A23L33/26

    摘要： A polydextrose composition that is substantially free of bitter tasting and color causing compounds is useful as a bulking agent in the incorporation of low calorie foods. In particular, the bulking agent may be combined with high intensity sweeteners as a replacement for sugar in foods so as to lower their calories without detracting from their texture and mouthfeel. Commercially available polydextrose that otherwise contains acidic compounds that cause bitter tastes and contribute to off colors thereby deterring its use in many food applications is purified through modified ion exchange column chromatography.

    Method of purifying polydextrose and composition containing same
    5.
    发明授权
    Method of purifying polydextrose and composition containing same 失效
    提取聚右旋糖的方法及含有其的组合物

    公开(公告)号：US4948596A

    公开(公告)日：1990-08-14

    申请号：US276500

    申请日：1988-11-22

    申请人： Frank J. Bunick ,  Shiuh J. Luo

    发明人： Frank J. Bunick ,  Shiuh J. Luo

    IPC分类号： A23G4/00 ,  A23G4/10 ,  A23L1/015 ,  A23L1/236 ,  A23L1/308 ,  C08B37/00

    CPC分类号： A23G4/10 ,  A23L27/30 ,  A23L33/26 ,  A23L5/23 ,  C08B37/0003 ,  Y10S426/804

    摘要： A process for purifying polydextrose to remove contaminants remaining from manufacturing sufficient to provide an organoleptically-acceptable polydextrose ingredient for foodstuffs which includes intimately contacting an aqueous solution of polydextrose having a concentration of from about 10% to about 50% with a polar organic solvent in a ratio of polydextgrose solvent of from about 5-15 of polydextrose to about 45-75 by weight of solvent. Furthermore, the mixture is allowed to equilibrate to form a substantially contaminant-containing fraction and a substantially polydextrose-containing fraction, followed by separating the fractions for use of the polydextrose-containing fraction. The present invention further includes compositions of foodstuffs including the purified polydextrose.

    摘要翻译： 一种用于纯化聚右旋糖的方法，以去除足以产生用于食品的感官可接受的聚右旋糖组分的制造物，所述污染物包括使浓度为约10％至约50％的浓度为约10％至约50％的聚右旋糖水溶液与极性有机溶剂的水溶液接触， 聚右旋糖溶剂的约5-15倍的聚右旋糖与约45-75重量份的溶剂的比例。 此外，允许混合物平衡以形成基本上含有污染物的级分和基本上含聚葡萄糖的级分，然后分离用于含聚葡萄糖的级分的级分。 本发明还包括包含纯化的聚右旋糖的食品的组合物。

    MANUFACTURE OF TABLET HAVING IMMEDIATE RELEASE REGION AND SUSTAINED RELEASE REGION
    7.
    发明申请
    MANUFACTURE OF TABLET HAVING IMMEDIATE RELEASE REGION AND SUSTAINED RELEASE REGION 有权
    具有立即释放区域和持续发布区域的片剂的制造

    公开(公告)号：US20110070304A1

    公开(公告)日：2011-03-24

    申请号：US12887560

    申请日：2010-09-22

    申请人： Leo B. Kriksunov ,  Harry S. Sowden ,  Joseph R. Luber ,  Frank J. Bunick

    发明人： Leo B. Kriksunov ,  Harry S. Sowden ,  Joseph R. Luber ,  Frank J. Bunick

    IPC分类号： A61K9/22 ,  A61P29/00 ,  B29C35/02 ,  B29C43/02 ,  B29C35/08

    CPC分类号： A61K9/209 ,  A61J3/10 ,  A61J2200/42 ,  A61K9/2013 ,  A61K9/2095 ,  B29C43/36 ,  B29C2043/3618

    摘要： In one aspect, the present invention features a process for making a tablet including a pharmaceutically active agent wherein the tablet has both an immediate release region and a modified release region. The method includes the steps of: (a) forming a tablet shape including a powder blend containing a pharmaceutically active agent and a thermally-sensitive material; and (b) applying energy in different amounts to different regions of the tablet shape to form the tablet in a manner such that: (i) a first region of the tablet shape is exposed to said energy for a sufficient period of time to melt the thermally-sensitive material within the first region to form said modified release region of said tablet; and (ii) a second region of said tablet shape is not so exposed to the energy such that said second region forms the immediate release region of said tablet.

    摘要翻译： 在一个方面，本发明的特征在于制备包含药物活性剂的片剂的方法，其中所述片剂具有即释释区域和修饰释放区域。 该方法包括以下步骤：（a）形成包含含有药物活性剂和热敏材料的粉末混合物的片剂形式; 和（b）将不同量的能量施加到片剂形状的不同区域以形成片剂，使得：（i）片剂形状的第一区域暴露于所述能量足够的时间以熔化 在第一区域内的热敏材料形成所述片剂的所述改性释放区域; 和（ii）所述片剂形状的第二区域不会暴露于能量，使得所述第二区域形成所述片剂的立即释放区域。

    NON-HOMOGENOUS DOSAGE FORM COATINGS
    9.
    发明申请
    NON-HOMOGENOUS DOSAGE FORM COATINGS 审中-公开
    非均质剂型涂料

    公开(公告)号：US20070231389A1

    公开(公告)日：2007-10-04

    申请号：US11691839

    申请日：2007-03-27

    申请人： Frank J. Bunick ,  Jen-Chi Chen

    发明人： Frank J. Bunick ,  Jen-Chi Chen

    IPC分类号： A61K9/24 ,  A61K9/50 ,  A61K9/16

    CPC分类号： A61K9/2873 ,  A61K9/1617 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/282 ,  A61K9/286 ,  A61K9/2893 ,  A61K9/5015 ,  A61K9/5042 ,  A61K9/5089

    摘要： The present invention is directed to liquid coating compositions and dosage forms having a continuous shell portion of a first composition and at least one discontinuous shell portion that is compositionally different located within the continuous shell portion. The present invention also provides a process for preparing a dosage form, which comprises coating a core with a continuous shell portion having a first composition and at least one discontinuous shell portion that is compositionally different located within the continuous portion, and then cooling the coated core. The coating compositions are particularly suited for forming shell coatings on solid pharmaceutical dosage forms.

    摘要翻译： 本发明涉及具有第一组合物的连续壳部分和在组成上不同于位于连续壳部分内的至少一个不连续壳部分的液体涂料组合物和剂型。 本发明还提供了一种制备剂型的方法，该方法包括用具有第一组合物的连续壳部分和至少一个在连续部分内组成不同的不连续壳部分涂覆芯，然后冷却涂层芯 。 涂料组合物特别适用于在固体药物剂型上形成壳涂层。