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    Compositions, methods, and computer systems related to making and administering modified T cells
    58.
    发明授权
    Compositions, methods, and computer systems related to making and administering modified T cells 有权
    与制备和施用修饰的T细胞相关的组合物，方法和计算机系统

    公开(公告)号：US09587237B2

    公开(公告)日：2017-03-07

    申请号：US13804224

    申请日：2013-03-14

    Applicant: Elwha LLC

    Inventor： Roderick A. Hyde ,  Wayne R. Kindsvogel ,  Gary L. McKnight

    IPC: C12N15/10

    CPC classification number: C12N15/1037 ,  C12N15/1093

    Abstract: Embodiments described herein relate to methods, devices, and computer systems thereof for the derivation of T CAR libraries (Universal Subject or Individual Subject) for personalized treatment of disease in a subject. In certain embodiments, differential screening of normal and diseased tissue expression data is utilized to determine disease-specific antigens and thereby generate T CAR cells reactive to such antigens to form a disease-specific library. In certain embodiments, determination of the most effective T CAR clones from the disease-specific library is based on the subject's own disease-specific antigens. In certain embodiments, a subject is treated with a therapeutically effective amount of T CAR clones.

    Abstract translation: 本文描述的实施例涉及用于推导T CAR图书馆（通用主题或个人主题）的方法，装置和计算机系统，用于个体化治疗受试者的疾病。 在某些实施方案中，利用正常和患病组织表达数据的差异筛选来确定疾病特异性抗原，从而产生对这种抗原反应的T CAR细胞以形成疾病特异性文库。 在某些实施方案中，来自疾病特异性文库的最有效的T CAR克隆的测定是基于受试者自己的疾病特异性抗原。 在某些实施方案中，用治疗有效量的T CAR克隆治疗受试者。

    PLATFORM AND METHOD FOR IDENTIFYING PAST EXPOSURE TO CHEMICAL AGENTS OR HEAVY METALS
    59.
    发明申请
    PLATFORM AND METHOD FOR IDENTIFYING PAST EXPOSURE TO CHEMICAL AGENTS OR HEAVY METALS 有权
    用于识别化学试剂或重金属的过度曝光的平台和方法

    公开(公告)号：US20170058275A1

    公开(公告)日：2017-03-02

    申请号：US15249842

    申请日：2016-08-29

    Applicant: The Johns Hopkins University

    Inventor： Mekbib Astatke

    IPC: C12N15/10 ,  G01N33/68 ,  C12Q1/68 ,  G01N33/543 ,  G01N33/564

    CPC classification number: C12N15/1037 ,  C12N15/1065 ,  C12Q1/6804 ,  C12Q1/6883 ,  G01N33/6845 ,  G01N2800/42

    Abstract: A method for determining past exposure to chemical agents or heavy metals may include coating a capture material with a capture reagent. The capture reagent may be selected based on an ability of the capture reagent to bind with a target antibody, and the target antibody may be an indicator associated with a particular chemical agent or heavy metal. The method may further include interrogating a clinical sample associated with an individual by forming a mixture of the capture material and the clinical sample, and determining an exposure status of the individual to the particular chemical agent or heavy metal based on whether the capture material demonstrates capture of the indicator.

    Abstract translation: 用于确定过去暴露于化学试剂或重金属的方法可以包括用捕获试剂涂覆捕获材料。 可以基于捕获试剂与靶抗体结合的能力来选择捕获试剂，并且靶抗体可以是与特定化学试剂或重金属相关联的指示剂。 该方法还可以包括通过形成捕获材料和临床样品的混合物来询问与个体相关的临床样品，以及基于捕获材料是否显示捕获来确定个体对特定化学试剂或重金属的暴露状态 的指标。

    Methods of constructing and screening libraries of peptide structures
    60.
    发明授权
    Methods of constructing and screening libraries of peptide structures 有权
    构建和筛选肽结构文库的方法

    公开(公告)号：US09567373B2

    公开(公告)日：2017-02-14

    申请号：US14038660

    申请日：2013-09-26

    Applicant: Phylogica Limited

    Inventor： Paul Michael Watt ,  Roland Dunbrack

    IPC: C40B40/10 ,  C07K14/00 ,  C07K1/04 ,  C12N15/10 ,  C40B30/02 ,  C07K1/00 ,  C07K7/08

    CPC classification number: C07K1/047 ,  C07K1/00 ,  C07K7/08 ,  C07K14/001 ,  C12N15/1037 ,  C12N15/1072 ,  C12N15/1089 ,  C12Q1/18 ,  C40B30/02 ,  C40B40/10 ,  G01N33/6824 ,  G01N33/6845 ,  G01N2500/10 ,  G06F19/18 ,  G06F19/22

    Abstract: The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer-readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.

    Abstract translation: 本发明提供用于生产用于药物筛选应用的肽结构库的方法，其能够独立于衍生自其的蛋白质中的人造支架或侧翼序列折叠或假定其天然构象。 图书馆可以是高度多样化的，因为它们代表了自然界中存在的蛋白质结构的所有组成部分。 这些库也可以是非冗余的或归一化的，使得存在于源数据集中和/或本质上的特定结构的偏移被删除。 在特别优选的实施方案中，本发明提供了通过该方法制备的30,000个独立折叠结构。 本发明还提供计算机可读介质和包含与肽库相关的结构数据的系统，以及显示和筛选文库的方法。

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