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145 条记录 (耗时 0.067 秒)

    Prosthetic Heart Valves
    52.
    发明申请
    Prosthetic Heart Valves 有权

    公开(公告)号：US20210236277A1

    公开(公告)日：2021-08-05

    申请号：US17233890

    申请日：2021-04-19

    申请人： CorMatrix Cardiovascular, Inc.

    发明人： Robert G. Matheny

    IPC分类号： A61F2/24 ,  A61L27/36 ,  A61L27/38 ,  A61L27/06 ,  A61L27/24

    摘要： Prosthetic heart valves having a conical shaped base valve structure formed from collagenous mammalian tissue and an expandable stent structure. The base valve structure includes a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, wherein the elongated ribbon members are positioned adjacent each other and form a plurality of fluid flow modulating regions that open when fluid into and through the base valve structure exhibits a positive pressure relative to the exterior pressure, i.e., a positive pressure differential, wherein the fluid is allowed to be transmitted out of the base valve structure, and transition to a closed configuration when the pressure differential between the interior valve pressure and exterior pressure reduces, wherein the fluid is restricted from flowing out of the base valve structure. The expandable stent structure includes a plurality of tethers adapted to pierce cardiovascular tissue and, thereby, position the base valve structure and, thereby, prosthetic valves formed therewith on said heart valve annulus.

    Prosthetic Venous Valves
    53.
    发明申请
    Prosthetic Venous Valves 有权

    公开(公告)号：US20210228358A1

    公开(公告)日：2021-07-29

    申请号：US17231784

    申请日：2021-04-15

    申请人： CorMatrix Cardiovascular Inc.

    发明人： Robert G. Matheny

    IPC分类号： A61F2/24 ,  A61L27/36 ,  A61L27/50 ,  A61L27/34 ,  A61L27/40 ,  A61L27/54 ,  A61L27/38

    摘要： A prosthetic venous valve having a conical shaped base valve member and a biomaterial delivery construct. The base valve member includes a plurality of fluid flow modulating means that open and allow antegrade blood to be transmitted out of the valve member when the valve member receives antegrade blood therein, and close and prevent retrograde blood from flowing into the valve member. The biomaterial delivery construct is adapted to receive and position the base valve member therein, and be disposed proximate a luminal wall of a venous vessel.

    Prosthetic Venous Valves
    54.
    发明申请
    Prosthetic Venous Valves 有权

    公开(公告)号：US20210177598A1

    公开(公告)日：2021-06-17

    申请号：US17177471

    申请日：2021-02-17

    申请人： CorMatrix Cardiovascular, Inc.

    发明人： Robert G. Matheny

    IPC分类号： A61F2/24 ,  A61L27/24 ,  A61L27/36 ,  A61L27/54 ,  A61K31/57 ,  A61K31/436 ,  A61K38/13 ,  A61K31/573 ,  A61K31/40 ,  A61K31/44 ,  A61K31/405 ,  A61K31/366

    摘要： A conical shaped venous valve structure formed from collagenous mammalian tissue. The valve structure includes a plurality of fluid flow modulating means that open and allow antegrade blood to be transmitted out of the valve structure and, into and through an associated cardiovascular vessel, when the valve structure is disposed in the cardiovascular vessel and the antegrade blood exhibits a positive pressure relative to the exterior pressure, whereby a negative hydrostatic pressure gradient is generated or present proximate the flow modulating means and/or a first positive pressure differential between first internal valvular pressure and first external valvular pressure is generated proximate the flow modulating regions, and close and prevent retrograde blood from flowing into the valve structure and, thereby, cardiovascular vessel, when a positive hydrostatic pressure gradient is generated or present proximate the flow modulating means and/or the first positive pressure differential transitions to a second pressure differential between second internal valvular pressure and second external valvular pressure, the second pressure differential being lower than the first positive pressure differential.

    Systems, apparatus and methods for sealing perivalvular leaks
    55.
    发明授权
    Systems, apparatus and methods for sealing perivalvular leaks 有权

    公开(公告)号：US10993802B2

    公开(公告)日：2021-05-04

    申请号：US15835714

    申请日：2017-12-08

    申请人： CorMatrix Cardiovascular, Inc.

    发明人： Robert G Matheny

    IPC分类号： A61F2/24

    摘要： A biocompatible and biodegradable construct having a base expandable member and an integral, internal support structure. The support structure is preferably formed from poly(glycerol sebacate) (PGS) or a magnesium alloy. The base member is preferably formed from acellular extracellular matrix (ECM) derived from small intestine submucosa (SIS) tissue that exhibits a flexible, porous, sponge-like structure adapted to expand upon absorption of a bodily fluid, wherein the construct seals a perivalvular leak when disposed proximate thereto.