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    TOPICAL DETOMIDINE FORMULATIONS
    51.
    发明申请
    TOPICAL DETOMIDINE FORMULATIONS 有权

    公开(公告)号：US20210137830A1

    公开(公告)日：2021-05-13

    申请号：US17259732

    申请日：2019-07-11

    Applicant: CLEXIO BIOSCIENCES LTD.

    Inventor： Mark ZAMANSKY ,  Erez KOREN

    IPC: A61K9/00 ,  A61K31/4174 ,  A61K45/06 ,  A61K47/14 ,  A61K9/06 ,  A61K9/107 ,  A61K9/12 ,  A61K47/32 ,  A61K47/34 ,  A61K9/16 ,  A61K9/51 ,  A61K9/70 ,  A61K47/44

    Abstract: Disclosed herein are topical formulations comprising about 0.001 to about 3 wt % detomidine or a salt thereof; and, a carrier that is suitable for topical administration to a subjects skin, wherein the carrier comprises hydrophilic and hydrophobic phase members in specified ratios, and wherein the detomidine is fully dissolved and chemically stable in the hydrophilic phase member. The topical formulations may be provided in the form of emulsions, creams, ointments, gels, spray patches, dispersions, and other specified forms. Also provided are methods for providing prolonged, non-systemic treatment for pain in a subject in need thereof comprising topically administering to the subject the presently disclosed topical formulations.

    TOPICAL DETOMIDINE FORMULATIONS
    56.
    发明公开
    TOPICAL DETOMIDINE FORMULATIONS 审中-公开

    公开(公告)号：US20230172909A1

    公开(公告)日：2023-06-08

    申请号：US18161215

    申请日：2023-01-30

    Applicant: CLEXIO BIOSCIENCES LTD.

    Inventor： Omer TSIPORI ,  Mark ZAMANSKY

    IPC: A61K31/4164 ,  A61P29/02 ,  A61K9/00

    CPC classification number: A61K31/4164 ,  A61P29/02 ,  A61K9/0014

    Abstract: Disclosed herein are topical formulations comprising about 0.001 to about 3 wt % detomidine or a salt thereof; and, a carrier that is suitable for topical administration to a subject's skin, wherein the carrier optionally comprises a water-miscible solubilizer that is present in an amount of up to 40% by weight of the formulation; wherein the formulation has a pH of 4.5 to 9, and, wherein the formulation provides prolonged, substantially non-systemic treatment for pain. Also provided are methods for providing prolonged, non-systemic treatment for pain in a subject in need thereof comprising topically administering to the subject the presently disclosed topical formulations.

    LONG ACTING GASTRIC RESIDENCE SYSTEM
    57.
    发明申请
    LONG ACTING GASTRIC RESIDENCE SYSTEM 有权

    公开(公告)号：US20230131186A1

    公开(公告)日：2023-04-27

    申请号：US18056387

    申请日：2022-11-17

    Applicant: CLEXIO BIOSCIENCES LTD.

    Inventor： Avshalom BEN MENACHEM ,  Ilan ZALIT

    IPC: A61M31/00 ,  A61K9/00

    Abstract: Provided herein are gastroretentive dosage forms (GRDFs) for extended retention in a human stomach, comprising a body comprising at least two arms, the body configured to transform between a collapsed configuration for ingestion, an expanded configuration for retention within the stomach and a disassembled configuration wherein after a predetermined time period has elapsed, the GRDF disassembles into at least two parts such that each of the disassembled parts of the GRDF is sized for exiting the stomach; and, an erodible insert comprising a therapeutic agent, a diagnostic agent, an electronical device, or a combination thereof.

    GASTRIC RESIDENCE SYSTEM
    58.
    发明申请
    GASTRIC RESIDENCE SYSTEM 有权

    公开(公告)号：US20230080008A1

    公开(公告)日：2023-03-16

    申请号：US18055991

    申请日：2022-11-16

    Applicant: CLEXIO BIOSCIENCES LTD.

    Inventor： Avshalom BEN MENACHEM ,  Ilan ZALIT ,  Elijahu BERKOVICH

    IPC: A61M31/00 ,  A61K47/69 ,  A61B5/00 ,  A61K9/00

    Abstract: The present disclosure is in the field of gastric resident systems. A device for extended retention in a stomach is provided. The device includes: first, second, and third arms, the second and third arms being connected to respective ends of the first arm. The device is configured to transform between a compressed configuration and an expanded configuration. The device further includes a biasing member configured to bias the device into the expanded configuration whereby the second and third arms are configured to mechanically engage each other to retain the system in the expanded configuration.

    DOSAGE FORMS FOR PREVENTING DRUG-FACILITATED ASSAULT
    59.
    发明申请
    DOSAGE FORMS FOR PREVENTING DRUG-FACILITATED ASSAULT 有权

    公开(公告)号：US20220202742A1

    公开(公告)日：2022-06-30

    申请号：US17608215

    申请日：2020-05-07

    Applicant: CLEXIO BIOSCIENCES LTD.

    Inventor： Michal YAHAV ,  Avi ROSENBERGER

    IPC: A61K31/135 ,  A61K9/00

    Abstract: Disclosed herein are immediate release oral dosage forms that comprising esketamine and one or more excipients that produce a visual indication of the presence of the dosage form within a vessel containing a liquid beverage. The visual indication can assist in thwarting an attempt to use the esketamine to render another individual more susceptible to criminal exploitation.

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