公开(公告)号：US20230255884A1

公开(公告)日：2023-08-17

申请号：US17607688

申请日：2020-05-01

Applicant: CLEXIO BIOSCIENCES LTD.

Inventor： Erez KOREN ,  Richard FISHER

IPC: A61K9/00 ,  A61K31/167 ,  A61K47/26 ,  A61K31/196 ,  A61K31/4174 ,  A61K31/192 ,  A61K47/10

CPC classification number: A61K9/0092 ,  A61K31/167 ,  A61K47/26 ,  A61K31/196 ,  A61K31/4174 ,  A61K31/192 ,  A61K47/10

Abstract: The invention is directed to fibrous structures finished with active pharmaceutical ingredients, as well as methods of their manufacturer and use.

公开(公告)号：US20210137830A1

公开(公告)日：2021-05-13

申请号：US17259732

申请日：2019-07-11

Applicant: CLEXIO BIOSCIENCES LTD.

Inventor： Mark ZAMANSKY ,  Erez KOREN

IPC: A61K9/00 ,  A61K31/4174 ,  A61K45/06 ,  A61K47/14 ,  A61K9/06 ,  A61K9/107 ,  A61K9/12 ,  A61K47/32 ,  A61K47/34 ,  A61K9/16 ,  A61K9/51 ,  A61K9/70 ,  A61K47/44

Abstract: Disclosed herein are topical formulations comprising about 0.001 to about 3 wt % detomidine or a salt thereof; and, a carrier that is suitable for topical administration to a subjects skin, wherein the carrier comprises hydrophilic and hydrophobic phase members in specified ratios, and wherein the detomidine is fully dissolved and chemically stable in the hydrophilic phase member. The topical formulations may be provided in the form of emulsions, creams, ointments, gels, spray patches, dispersions, and other specified forms. Also provided are methods for providing prolonged, non-systemic treatment for pain in a subject in need thereof comprising topically administering to the subject the presently disclosed topical formulations.