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69 条记录 (耗时 0.045 秒)

    Janus dendrimers and dendrons
    51.
    发明授权
    Janus dendrimers and dendrons 失效
    珍珠菌树枝状大分子和树突

    公开(公告)号：US07977452B2

    公开(公告)日：2011-07-12

    申请号：US11885244

    申请日：2006-03-27

    申请人： Donald A. Tomalia ,  Veera Reddy Pulgam ,  Douglas R. Swanson ,  Boahua Huang

    发明人： Donald A. Tomalia ,  Veera Reddy Pulgam ,  Douglas R. Swanson ,  Boahua Huang

    IPC分类号： C08G75/00

    CPC分类号： C08G83/003 ,  C08G81/00

    摘要： This invention provides a cost effective process and new Janus dendrimers where at least two dendrons are attached at the core (with or without a connector group) and where at least two of the dendrons have different functionality. Preferred are those Janus dendrimers where at least one dendron is a PEHAM dendron. Thus these Janus dendrimers are heterobifunctional in character and use unique ligation chemistry with single site functional dendrons, di-dendrons and multi-dendrons. Also included are Janus dendrons which may be used as intermediates to make the Janus dendrimers or to further react with another reactive moiety. These Janus dendrimers can provide several new dendrimer moieties, namely: combinatorial libraries of bifunctional structures; combined target director and signaling dendrimers; specific targeting entities for diagnostic and therapeutic applications, such as for example targeted MRI agents, targeted radionuclide delivery for diseases such as cancer, and targeted photosensitive or radiowave sensitive agents.

    摘要翻译： 本发明提供了一种成本有效的方法和新的Janus树枝状大分子，其中至少两个树突状物连接在核心处（具有或不具有连接基团），并且其中至少两个枝状突起具有不同的功能。 那些Janus树枝状大分子是首选，其中至少有一个树突是PEHAM树突。 因此，这些Janus树枝状大分子在性质上是异双功能的，并且使用独特的连接化学物质，其具有单位点功能性树突，二树枝状突起和多枝状突起。 还包括Janus dendron，其可以用作中间体以制备Janus树枝状大分子或进一步与另一反应性部分反应。 这些Janus树枝状大分子可以提供几个新的树枝状大分子部分，即：双功能结构的组合文库; 组合目标主任和信号树枝状大分子; 用于诊断和治疗应用的特异性靶向实体，例如靶向MRI剂，用于诸如癌症的疾病的靶向放射性核素递送，以及靶向感光或无线电波敏感剂。

    Nanocomposites of dendritic polymers
    52.
    发明授权
    Nanocomposites of dendritic polymers 有权

    公开(公告)号：US06664315B2

    公开(公告)日：2003-12-16

    申请号：US09780973

    申请日：2001-02-10

    申请人： Donald A. Tomalia ,  Lajos Balogh

    发明人： Donald A. Tomalia ,  Lajos Balogh

    IPC分类号： C08J300

    CPC分类号： B82Y30/00 ,  C08G83/003 ,  C08J3/02 ,  C08J2300/00 ,  C08J2300/202 ,  Y10S977/753 ,  Y10S977/754 ,  Y10S977/788 ,  Y10S977/835

    摘要： In the present invention, an inorganic reactant is, or reactants are, localized with respect to a dendritic polymer by physical constraint within or by a non-covalent conjugation to the dendritic polymer. The localized inorganic reactant or reactants is/are subsequently transformed to form a reaction product which is immobilized with respect to the dendritic polymer. This immobilization occurs on a nanoscopic scale as a consequence of the combined effects of structural, chemical and physical changes without having covalent bonds between the product(s) and the dendritic container and results in new compositions of matter called dendritic nanocomposites. The resulting nanocomposite material can be used to produce revolutionary products such as water soluble elemental metals, with specific applications including magnetic resonance imaging, catalytic, magnetic, optical, photolytic and electroactive applications.

    Electrically conducting dendrimers
    55.
    发明授权
    Electrically conducting dendrimers 失效
    导电树枝状大分子

    公开(公告)号：US6043336A

    公开(公告)日：2000-03-28

    申请号：US311

    申请日：1998-01-26

    申请人： Larry L. Miller ,  Donald A. Tomalia ,  Robert G. Duan

    发明人： Larry L. Miller ,  Donald A. Tomalia ,  Robert G. Duan

    IPC分类号： C08G73/06 ,  C08G83/00 ,  C08G63/00 ,  C08G73/00

    CPC分类号： C08G83/003 ,  C08G73/0688 ,  Y10S424/16

    摘要： An electrically conductive polymer is comprised of the reaction product of a dendrimer and an electrophoric compound which exhibits .pi.-stacking upon reduction. The reaction product which is a peripherally modified dendrimer is formed and reduced, either chemically or electrochemically, in a polar solvent. The reduced electrophoric moieties aggregate (form .pi.-stacks) to form electrically conductive pathways. The reduced peripherally modified dendrimers of the invention can be cast into films and other solid forms to provide flexible electrical conductors and semiconductors. The conductive polymers of the invention exhibit electrical conductivities comparable to that of doped polyacetalene, but are oxygen and moisture stable.

    摘要翻译： PCT No.PCT / US96 / 12283 Sec。 371日期1998年1月26日 102（e）1998年1月26日PCT PCT 1996年7月25日PCT公布。 出版物WO97 / 05631 日期1997年2月13日导电聚合物由树枝状聚合物和电还原化合物的反应产物组成，其在还原时显示出π堆叠。 作为外围改性的树枝状聚合物的反应产物在极性溶剂中以化学或电化学方式形成和还原。 还原的电化学部分聚集（形成π-叠层）以形成导电通路。 本发明的减少的周边改性的树枝状大分子可以铸成薄膜和其它固体形式以提供柔性电导体和半导体。 本发明的导电聚合物表现出与掺杂的聚缩醛相当的电导率，但是氧和水分稳定。

    Ion exchange/chelation resins containing dense star polymers having ion exchange or chelate capabilities
    60.
    发明授权
    Ion exchange/chelation resins containing dense star polymers having ion exchange or chelate capabilities 失效
    含有具有离子交换或螯合能力的致密星形聚合物的离子交换/螯合树脂

    公开(公告)号：US4871779A

    公开(公告)日：1989-10-03

    申请号：US812479

    申请日：1985-12-23

    申请人： George R. Killat ,  Donald A. Tomalia

    发明人： George R. Killat ,  Donald A. Tomalia

    IPC分类号： B01J39/20 ,  B01J45/00 ,  C08F8/30 ,  C08G83/00

    CPC分类号： C08G83/003 ,  B01J39/20 ,  B01J45/00 ,  C08F8/32 ,  Y10S424/16

    摘要： Ion exchange resins and chelate resins are provided with ion exchange or chelate capability by depositing on an insoluble substrate dense star polymers having terminal group densities greater than conventional star polymers exhibiting greater and more uniform reactivity than their corresponding conventional star polymers. For example, a third generation, amine-terminated polyamidoamine dense star polymer prepared from ammonia, methyl acrylate and ethylenediamine having 1.24.times.10.sup.-4 amine moieties per unit volume (cubic Angstrom units) in contrast to the 1.58.times.10.sup.-6 amine moieties per unit volume contained by a conventional star polymer can be reacted with a chloromethylated styrene/divinyl copolymer (insoluble substrate) to form a desirably weak base anion exchange resin.

    摘要翻译： 离子交换树脂和螯合树脂具有离子交换或螯合能力，通过沉积在不溶性底物上，具有比其相应的常规星形聚合物显示更大和更均匀的反应性的常规星形聚合物的端基密度的致密星形聚合物。 例如，与每单位体积的1.58×10-6胺部分相反，由氨，甲基丙烯酸酯和乙二胺制备的第三代胺封端的聚酰氨胺胺致密星形聚合物，每单位体积（立方单位）具有1.24×10 -4胺部分 通过常规的星形聚合物可以与氯甲基化苯乙烯/二乙烯基共聚物（不溶性底物）反应，形成理想的弱碱阴离子交换树脂。