Polymer conjugates of opioid antagonists
    51.
    发明授权
    Polymer conjugates of opioid antagonists 有权
    阿片样物质拮抗剂的聚合物共轭物

    公开(公告)号:US07662365B2

    公开(公告)日:2010-02-16

    申请号:US11332964

    申请日:2006-01-17

    IPC分类号: A81K31/74

    CPC分类号: A61K47/60

    摘要: The invention provides polymer conjugates of opioid antagonists comprising a polymer, such as poly(ethylene glycol), covalently attached to an opioid antagonist. The linkage between the polymer and the opioid antagonist is preferably hydrolytically stable. The invention also includes a method of treating one or more side effects associated with the use of opioid analgesics, such as constipation, nausea, or pruritus, by administering a polymer conjugate of the invention.

    摘要翻译: 本发明提供了阿片样物质拮抗剂的聚合物缀合物,其包含与阿片样物质拮抗剂共价连接的聚合物,例如聚(乙二醇)。 聚合物和阿片样物质拮抗剂之间的连接优选是水解稳定的。 本发明还包括通过施用本发明的聚合物缀合物来治疗与使用阿片样镇痛药如便秘,恶心或瘙痒相关的一种或多种副作用的方法。

    Method and system of recording data from borescopic inspection

    公开(公告)号:US11120651B2

    公开(公告)日:2021-09-14

    申请号:US16063966

    申请日:2017-12-05

    申请人: Lin Cheng

    发明人: Lin Cheng

    摘要: The present invention provides a method and a system for recording data from the borescopic inspection meaning checking whether defects occur in equipment consists of components with a borescope, the method comprising: (1) constructing the hierarchical structure of components in the equipment; the hierarchical structures of components include two levels of Module and Part, the Module comprising one or more Part(s); (2) defining the general description template of the defects; (3) defining the evaluation template for the inspection results of the Part(s); (4) defining the conclusion template of defects on Module; (5) standardizing input of data from the borescopic inspection; (6) concluding based on data from the borescopic inspection. According to the present invention, it provides an excellent measurement method for improving the reliability of modular mechanical products through quantizing the overall trend of internal defects.

    Vertical junction field effect transistors and bipolar junction transistors
    54.
    发明授权
    Vertical junction field effect transistors and bipolar junction transistors 有权
    垂直结场效应晶体管和双极结型晶体管

    公开(公告)号:US08587024B2

    公开(公告)日:2013-11-19

    申请号:US13613295

    申请日:2012-09-13

    申请人: Lin Cheng

    发明人: Lin Cheng

    IPC分类号: H01L29/66

    摘要: Methods of making semiconductor devices such as vertical junction field effect transistors (VJFETs) or bipolar junction transistors (BJTs) are described. The methods do not require ion implantation. The VJFET device has an epitaxially regrown n-type channel layer and an epitaxially regrown p-type gate layer as well as an epitaxially grown buried gate layer. Devices made by the methods are also described.

    摘要翻译: 描述了制造诸如垂直结型场效应晶体管(VJFET)或双极结型晶体管(BJT)的半导体器件的方法。 该方法不需要离子注入。 VJFET器件具有外延再生长的n型沟道层和外延再生长的p型栅极层以及外延生长的掩埋栅极层。 还描述了通过该方法制造的装置。

    Anti-glare optical module and method for manufacturing the same
    55.
    发明申请
    Anti-glare optical module and method for manufacturing the same 审中-公开
    防眩光模块及其制造方法

    公开(公告)号:US20110096403A1

    公开(公告)日:2011-04-28

    申请号:US12588629

    申请日:2009-10-22

    IPC分类号: G02B27/00 G02B1/12

    CPC分类号: G02B1/118 G02B1/12

    摘要: An anti-glare optical module includes a substrate unit and a thin film unit. The thin film unit is disposed on the top surface of the substrate unit. The thin film unit has a base surface that has a height relative to the top surface of the substrate unit, the thin film unit has a plurality of convex structures, each convex structure has a curvature radius, the curvature radiuses of every two adjacent convex structures are different, a plurality of lower points each formed between every two convex structures and on the base surface, and each convex structure has an upper point. Therefore, the thin film unit has a good scattering effect for reflective light, can maintain the excellent transmittance and can reduce the flicker points by the convex structures, so that using the convex structures can prevent the eyes of the user from being effected by flicker points.

    摘要翻译: 防眩光模块包括基板单元和薄膜单元。 薄膜单元设置在基板单元的顶表面上。 薄膜单元具有相对于基板单元的顶表面的高度的基面,薄膜单元具有多个凸结构,每个凸结构具有曲率半径,每两个相邻的凸结构的曲率半径 每个凸起结构之间和基底表面上形成多个下部点,并且每个凸起结构都具有上部点。 因此,薄膜单元对反射光具有良好的散射效果,可以保持优异的透射率并且可以通过凸起结构来减少闪烁点,使得使用凸起结构可以防止用户的眼睛受到闪烁点的影响 。

    POLYMER CONJUGATES OF OPIOID ANTAGONISTS
    58.
    发明申请
    POLYMER CONJUGATES OF OPIOID ANTAGONISTS 有权
    聚合物对阿片类拮抗剂的结合

    公开(公告)号:US20100105715A1

    公开(公告)日:2010-04-29

    申请号:US12574335

    申请日:2009-10-06

    IPC分类号: A61K31/485 A61P1/08 A61P1/10

    CPC分类号: A61K47/60

    摘要: The invention provides polymer conjugates of opioid antagonists comprising a polymer, such as poly(ethylene glycol), covalently attached to an opioid antagonist. The linkage between the polymer and the opioid antagonist is preferably hydrolytically stable. The invention also includes a method of treating one or more side effects associated with the use of opioid analgesics, such as constipation, nausea, or pruritus, by administering a polymer conjugate of the invention.

    摘要翻译: 本发明提供了阿片样物质拮抗剂的聚合物缀合物,其包含与阿片样物质拮抗剂共价连接的聚合物,例如聚(乙二醇)。 聚合物和阿片样物质拮抗剂之间的连接优选是水解稳定的。 本发明还包括通过施用本发明的聚合物缀合物来治疗与使用阿片样镇痛药如便秘,恶心或瘙痒相关的一种或多种副作用的方法。

    STEREOSELECTIVE REDUCTION OF A MORPHINONE
    59.
    发明申请
    STEREOSELECTIVE REDUCTION OF A MORPHINONE 有权
    选择性还原吗啡酮

    公开(公告)号:US20090221766A1

    公开(公告)日:2009-09-03

    申请号:US12297632

    申请日:2007-04-19

    IPC分类号: C08G73/00 C07D489/02

    CPC分类号: C07D489/02 Y02P20/55

    摘要: A synthetic method is provided, wherein the method comprises stereoselectively reducing a ketone of a morphinone to form a reduced morphinone and optionally covalently attaching a water soluble polymer to the reduced morphinone.

    摘要翻译: 提供了一种合成方法,其中所述方法包括立体选择性还原吗啡酮的酮以形成还原的吗啡酮并且任选地将水溶性聚合物共价连接到还原的吗啡酮上。