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公开(公告)号：US20230295602A1
公开(公告)日：2023-09-21
申请号：US18300251
申请日：2023-04-13
发明人： Howard Chou , Ling Chen , Wenqiang Lu , Xiucai Liu
CPC分类号： C12N9/88 , C07K14/47 , C12N15/70 , C12Y401/01018 , C07K2319/00
摘要： This invention provides acid decarboxylase-prion subunit fusion polypeptides, nucleic acid sequences, expression vectors, and host cells expression such fusion polypeptides to produce various amino acids and derivatives of the amino acids such as polyamines.
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公开(公告)号：US20230012061A1
公开(公告)日：2023-01-12
申请号：US17783952
申请日：2020-01-15
发明人： Chaoxu Sun , Xiaochen Xu , Xiucai Liu
摘要： The present disclosure provides a polyamide 5X staple fiber, a preparation method and use thereof. The polyamide 5X staple fiber has a denier of 8.0-30.0D, a breaking strength of 2.0-6.0 cN/dtex, and an elongation at break of 30-100%. The polyamide 5X staple fiber has good mechanical properties and softness, and a blended wool yarn for manufacturing carpets with good mechanical properties, dyeability, and wear resistance can be obtained by using the polyamide 5X staple fiber.
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公开(公告)号：US11512302B2
公开(公告)日：2022-11-29
申请号：US16614265
申请日：2017-05-16
发明人： Howard Chou , Wenqiang Lu , Ling Chen , Lijun Yu , Xiucai Liu
摘要： The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganism.
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公开(公告)号：US11427525B2
公开(公告)日：2022-08-30
申请号：US17039165
申请日：2020-09-30
发明人： Bingbing Qin , Yufeng Yang , Xiucai Liu
IPC分类号： C07C51/43 , B01D17/02 , C07C55/21 , C12P7/6409 , C07C51/02 , C07C51/42 , C07C51/347 , C12P7/44
摘要： The present disclosure provides method for isolating a long chain dicarboxylic acid such as a substantially pure or pure long chain dicarboxylic acid from a fermentation broth containing microbial cells.
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公开(公告)号：US20220105469A1
公开(公告)日：2022-04-07
申请号：US17551335
申请日：2021-12-15
发明人： Chen Yang , Shuhua Zhang , Yufeng Yang , Xiucai Liu
摘要： The present disclosure provides a system for extracting long chain dicarboxylic acid, the system comprising: a primary membrane filtration unit, a first crystallization unit, a first separation unit, a first dissolution tank, a secondary membrane filtration unit, a second separation unit, a second crystallization unit and a third separation unit. By the system for extracting long chain dicarboxylic acid of an embodiment of the present invention, the resulted long chain dicarboxylic acid product has a high purity, very low and even no residual alkane residue, and organic solvent-free.
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公开(公告)号：US20220080357A1
公开(公告)日：2022-03-17
申请号：US17507959
申请日：2021-10-22
发明人： Chen Yang , Bingbing Qin , Yufeng Yang , Kai Wang , Xiucai Liu
摘要： The present disclosure provides a system for refining long chain dicarboxylic acid, comprising: a first membrane filtration unit, for a first membrane filtration of a long chain dicarboxylic acid fermentation broth or a treated liquid therefrom; a first decolorization unit, for carrying out a first decolorization treatment to the filtrate obtained after the membrane filtration; a first acidification/crystallization unit, for carrying out a first acidification/crystallization of a filtrate obtained after the membrane filtration to give a solid-liquid mixture; a first separation unit, for a solid-liquid separation of the solid-liquid mixture; a drying unit, for drying the solid separated by the separation unit to give a first solid. By using the refining system according to the present disclosure, the purity of the obtained product is high, and the disadvantages such as poor quality of the product obtained by crystallization from a solvent and environment pollution caused by a solvent can be overcome.
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57.发明授权公开(公告)号：US11118201B2
公开(公告)日：2021-09-14
申请号：US16648194
申请日：2017-09-22
发明人： Howard Chou , Ling Chen , Xiucai Liu
摘要： The invention provides microorganisms genetically modified to co-overexpress a carbohydrate binding module and lysine decarboxylase polypeptides in a mesophilic host to enhance the production of lysine derivatives by the microorganism, method of generating such microorganism, and methods of producing lysine derivatives using the genetically modified microorganisms.
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公开(公告)号：US11091742B2
公开(公告)日：2021-08-17
申请号：US16229084
申请日：2018-12-21
发明人： Wenbo Liu , Min Xu , Howard Chou , Xiucai Liu
摘要： The invention relates to the directed evolution of CYP52A12 gene and the use thereof for the production of a dicarboxylic acid. In particular, it relates to a method of preparing a long chain dicarboxylic acid producing strain by using directed evolution and homologous recombination, a strain obtained by the method that is capable of producing a long chain dicarboxylic acid under an acidic condition and the use thereof. In particular, the invention relates to a method of preparing a long chain dicarboxylic acid producing strain by directed evolution of CYP52A12 gene and homologous recombination, a strain obtained by the method that is capable of producing a long chain dicarboxylic acid under an acidic condition and the use thereof. By directed evolution of CYP52A12 gene, one strain which has a base mutation at the promoter region of said gene and is capable of producing a long chain dicarboxylic acid under an acidic condition in a shortened fermentation time is screened out in the invention.
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公开(公告)号：US11041177B2
公开(公告)日：2021-06-22
申请号：US16473149
申请日：2016-12-30
发明人： Howard Chou , Wenqiang Lu , Ling Chen , Xiucai Liu
摘要： The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganism.
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公开(公告)号：US20210155962A1
公开(公告)日：2021-05-27
申请号：US16614265
申请日：2017-05-16
发明人： Howard Chou , Wenqiang Lu , Ling Chen , Lijun Yu , Xiucai Liu
摘要： The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganism.
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