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公开(公告)号：US11078473B2
公开(公告)日：2021-08-03
申请号：US16473215
申请日：2016-12-30
发明人： Howard Chou , Ling Chen , Wenqiang Lu , Xiucai Liu
摘要： The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganisms.
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公开(公告)号：US20230295602A1
公开(公告)日：2023-09-21
申请号：US18300251
申请日：2023-04-13
发明人： Howard Chou , Ling Chen , Wenqiang Lu , Xiucai Liu
CPC分类号： C12N9/88 , C07K14/47 , C12N15/70 , C12Y401/01018 , C07K2319/00
摘要： This invention provides acid decarboxylase-prion subunit fusion polypeptides, nucleic acid sequences, expression vectors, and host cells expression such fusion polypeptides to produce various amino acids and derivatives of the amino acids such as polyamines.
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公开(公告)号：US11512302B2
公开(公告)日：2022-11-29
申请号：US16614265
申请日：2017-05-16
发明人： Howard Chou , Wenqiang Lu , Ling Chen , Lijun Yu , Xiucai Liu
摘要： The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganism.
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公开(公告)号：US11041177B2
公开(公告)日：2021-06-22
申请号：US16473149
申请日：2016-12-30
发明人： Howard Chou , Wenqiang Lu , Ling Chen , Xiucai Liu
摘要： The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganism.
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公开(公告)号：US20210155962A1
公开(公告)日：2021-05-27
申请号：US16614265
申请日：2017-05-16
发明人： Howard Chou , Wenqiang Lu , Ling Chen , Lijun Yu , Xiucai Liu
摘要： The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganism.
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公开(公告)号：US20190330613A1
公开(公告)日：2019-10-31
申请号：US16464104
申请日：2016-11-24
发明人： Howard Chou , Ling Chen , Wenqiang Lu , Xiucai Liu
摘要： This invention provides acid decarboxylase-prion subunit fusion polypeptides, nucleic acid sequences, expression vectors, and host cells expression such fusion polypeptides to produce various amino acids and derivatives of the amino acids such as polyamines.
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