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公开(公告)号：US20240209149A1
公开(公告)日：2024-06-27
申请号：US18583132
申请日：2024-02-21
发明人： Xiaohui ZHOU , Xiucai LIU
IPC分类号： C08G69/40
CPC分类号： C08G69/40
摘要： A bio-based polyamide elastomer and a preparation method therefor. The bio-based polyamide elastomer is prepared using specific aliphatic diacid and pentanediamine prepared by biological methods as monomers. The polyamide elastomer of the present disclosure has excellent performance and stable monomer supply, solves the problem of excessively high cost of polyamide elastomer, expands the application scenarios of elastomers, and has high commercial value.
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公开(公告)号：US12017182B2
公开(公告)日：2024-06-25
申请号：US17507959
申请日：2021-10-22
发明人： Chen Yang , Bingbing Qin , Yufeng Yang , Kai Wang , Xiucai Liu
IPC分类号： B01D15/08 , B01D3/10 , B01D3/12 , B01D9/00 , B01D25/12 , B01D29/00 , B01D36/00 , B01D61/14 , B01D61/18 , B01D61/36 , B01D69/02
CPC分类号： B01D61/18 , B01D3/10 , B01D3/12 , B01D9/005 , B01D9/0068 , B01D15/08 , B01D25/12 , B01D29/00 , B01D36/00 , B01D61/145 , B01D61/147 , B01D61/149 , B01D61/364 , B01D69/02 , B01D2009/0086 , B01D2311/103 , B01D2311/106 , B01D2311/2626 , B01D2311/2642 , B01D2311/2649 , B01D2311/2669 , B01D2317/025 , B01D2325/0283 , B01D2325/20
摘要： The present disclosure provides a system for refining long chain dicarboxylic acid, comprising: a first membrane filtration unit, for a first membrane filtration of a long chain dicarboxylic acid fermentation broth or a treated liquid therefrom; a first decolorization unit, for carrying out a first decolorization treatment to the filtrate obtained after the membrane filtration; a first acidification/crystallization unit, for carrying out a first acidification/crystallization of a filtrate obtained after the membrane filtration to give a solid-liquid mixture; a first separation unit, for a solid-liquid separation of the solid-liquid mixture; a drying unit, for drying the solid separated by the separation unit to give a first solid. By using the refining system according to the present disclosure, the purity of the obtained product is high, and the disadvantages such as poor quality of the product obtained by crystallization from a solvent and environment pollution caused by a solvent can be overcome.
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公开(公告)号：US20220389623A1
公开(公告)日：2022-12-08
申请号：US17769779
申请日：2020-01-15
申请人： CATHAY BIOTECH INC. , CIBT America Inc. , CATHAY (JINXIANG) BIOMATERIAL CO., LTD. , CATHAY (WUSU) BIOMATERIAL CO., LTD.
发明人： Chaoxu SUN , Xiucai LIU
摘要： The present invention relates to the technical field of polyamide materials, and specifically relates to a polyamide sea-island fiber and a process for producing the same and the use thereof. In the polyamide sea-island fiber, the island component is a polyamide resin selected from one of polyamide 56, polyamide 510, polyamide 511, polyamide 512, polyamide 513, polyamide 514, polyamide 515 and polyamide 516, preferably polyamide 56 or polyamide 510; the sea component is one of polyethylene, low-density polyethylene, polystyrene, water-soluble polyesters, polyesters and polyurethanes, preferably polyethylene, low-density polyethylene or water-soluble polyester. The polyamide sea-island fiber of the present invention has better mechanical properties, better softness, good dyeing properties, high grade of dyeing grey scale, high dye uptake, high dyeing depth and high color fastness.
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公开(公告)号：US20220282404A1
公开(公告)日：2022-09-08
申请号：US17637093
申请日：2020-01-15
发明人： Chaoxu SUN , Xiucai LIU
摘要： The present invention relates to the technical field of polyamide materials, and provides a polyamide 56 pre-oriented yarn and a polyamide 56 draw textured yarn with a low shrinkage in boiling water, a process for producing the same and a use thereof. The raw materials for producing the polyamide 56 fiber comprise 1,5-pentane diamine and adipic acid, or a polyamide 56 resin obtained by polymerizing 1,5-pentane diamine monomer and adipic acid monomer; wherein the polyamide 56 fiber has a shrinkage in boiling water of 9% or less, wherein the polyamide 56 fiber comprises a polyamide 56 pre-oriented yarn with a low shrinkage in boiling water and a polyamide 56 draw textured yarn with a low shrinkage in boiling water. The polyamide 56 fiber has good mechanical properties, dyeing uniformity and dimensional stability. The process for producing the polyamide 56 fiber does not require modification to existing equipments for texturing polyamide fibers and thus reduces production costs.
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公开(公告)号：US11261217B2
公开(公告)日：2022-03-01
申请号：US16738663
申请日：2020-01-09
发明人： Howard Chou , Naiqiang Li , Xiucai Liu
摘要： One aspect provided herein relates to lysine decarboxylase polypeptides comprising mutants of SEQ ID NO: 2 (i.e., mutants of Klebsiella oxytoca (K. oxytoca) Ldc) and/or fragments thereof. In certain embodiments, the mutants or fragments thereof may have at least about 95% sequence identity with SEQ ID NO: 2. Another aspect provided herein relates to a DNA polynucleotide comprising one or more lysine decarboxylase nucleotide sequences of mutants of SEQ ID NO: 1 (i.e., mutants of K. oxytoca ldc), fragments thereof, or fragments of SEQ ID NO: 1 (i.e., fragments of K. oxytoca ldc). In certain embodiments, the DNA polynucleotide as disclosed herein may encode one or more lysine decarboxylase polypeptides provided herein. In certain embodiments, the DNA polynucleotide as disclosed herein may encode SEQ ID NO: 2, mutants, and/or fragments thereof. In certain embodiments, the lysine decarboxylase nucleotide sequences provided herein may have at least 95% sequence identity with SEQ ID NO: 1 or SEQ ID NO: 3. Another aspect provided herein relates to expression vectors comprising the DNA polynucleotides described herein used for production of a lysine-derived product. Other aspects provided herein include transformants, mutant host cells, methods for the production of lysine decarboxylases, and methods for the production of a lysine-derived product.
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公开(公告)号：US20210054423A1
公开(公告)日：2021-02-25
申请号：US16961106
申请日：2018-01-09
发明人： Howard CHOU , Ling CHEN , Yunfeng LEI , Xiucai LIU
摘要： The invention provides microorganisms genetically modified to overexpress biofilm dispersal related polypeptides to enhance the production of lysine and lysine derivatives by the microorganism, method of generating such microorganism, and methods of producing lysine and lysine derivatives using the genetically modified microorganisms.
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7.发明申请公开(公告)号：US20200255873A1
公开(公告)日：2020-08-13
申请号：US16648194
申请日：2017-09-22
发明人： Howard Chou , Ling Chen , Xiucai Liu
IPC分类号： C12P13/00 , C12N1/20 , C12N9/88 , C07K14/245
摘要： The invention provides microorganisms genetically modified to co-overexpress a carbohydrate binding module and lysine decarboxylase polypeptides in a mesophilic host to enhance the production of lysine derivatives by the microorganism, method of generating such microorganism, and methods of producing lysine derivatives using the genetically modified microorganisms.
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公开(公告)号：US20190338323A1
公开(公告)日：2019-11-07
申请号：US16514518
申请日：2019-07-17
发明人： Howard CHOU , Xiucai Liu
IPC分类号： C12P13/08 , C12P13/00 , C12N9/88 , C07K14/36 , C07K14/245 , C12N15/77 , C12N15/70 , C07K14/35
摘要： One aspect of the invention relates to a mutant polypeptide comprising the amino acid sequence of Escherichia coli tetracycline efflux pump A (TetA). Another aspect of the invention relates to a polynucleotide encoding a polypeptide of TetA, a fragment thereof, or a mutant thereof. Another aspect of the invention relates to a first expression plasmid vector comprising one or more first polynucleotides encoding a first polypeptide comprising a tetracycline efflux pump polypeptide, a fragment thereof or a mutant thereof, one or more second polynucleotides independently selected from the group consisting of a third polynucleotide encoding a third polypeptide comprising a lysine decarboxylase polypeptide, a fragment thereof or a mutant thereof, and a fourth polynucleotide encoding a fourth polypeptide comprising a lysine biosynthesis polypeptide, a fragment thereof or a mutant thereof. Another aspect of the invention relates to a transformant comprising one or more expression plasmid vectors as described herein in a host cell. Another aspect of the invention relates to a mutant host cell comprising one or more first, third or fourth polynucleotides as described herein integrated into a chromosome of a host cell. Another aspect of the invention relates to a method for producing a lysine comprising obtaining a transformant and/or mutant host cell as disclosed herein, culturing the transformant and/or mutant host cell under conditions effective for the expression of the lysine; and harvesting the lysine. Other aspects of the invention relate to methods for producing biobased cadaverine using the transformants disclosed herein, and biobased cadaverine prepared by the method disclosed herein, and polyamides formed using the biobased cadaverine as disclosed herein and compositions thereof.
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公开(公告)号：US20190330613A1
公开(公告)日：2019-10-31
申请号：US16464104
申请日：2016-11-24
发明人： Howard Chou , Ling Chen , Wenqiang Lu , Xiucai Liu
摘要： This invention provides acid decarboxylase-prion subunit fusion polypeptides, nucleic acid sequences, expression vectors, and host cells expression such fusion polypeptides to produce various amino acids and derivatives of the amino acids such as polyamines.
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10.发明申请公开(公告)号：US20190194705A1
公开(公告)日：2019-06-27
申请号：US16325610
申请日：2016-08-15
发明人： Howard CHOU , Xiucai LIU
CPC分类号： C12P13/08 , C07K14/195 , C12N1/20 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N2510/02 , C12P13/001 , C12R1/15 , C12R1/19 , C12Y401/01018
摘要： Provided herein is a genetically modified host cell comprising a heterologous nucleic acid encoding a biofilm dispersal polypeptide that decreases intracellular c-di-GMP levels and enhances the production of lysine and lysine derivatives. Further provided are methods of generating such cell and producing lysine and lysine derivatives using the genetically modified host cell.
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