公开(公告)号：US07015220B2

公开(公告)日：2006-03-21

申请号：US10783325

申请日：2004-02-20

Applicant: Steven W. Andrews ,  Julie A. Wurster ,  Edward H. Wang ,  Thomas Malone

Inventor： Steven W. Andrews ,  Julie A. Wurster ,  Edward H. Wang ,  Thomas Malone

IPC: A61K31/404 ,  A61K31/5375 ,  C07D413/02 ,  C07D241/04 ,  C07D209/04

CPC classification number: C07D295/088 ,  A61K31/404 ,  C07D209/34 ,  C07D295/135 ,  C07D401/10 ,  C07D403/12

Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

公开(公告)号：US07005444B2

公开(公告)日：2006-02-28

申请号：US10256381

申请日：2002-09-26

Applicant: Steven W. Andrews ,  Julie A. Wurster

Inventor： Steven W. Andrews ,  Julie A. Wurster

IPC: A61K31/4155 ,  C07D403/12

CPC classification number: C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract translation: 本发明涉及能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子。

公开(公告)号：US06747025B1

公开(公告)日：2004-06-08

申请号：US10389416

申请日：2003-03-13

Applicant: Steven W. Andrews ,  Michael E. Garst ,  Xialing Guo ,  Jonathan J. Hebert ,  Thomas Malone ,  Julie A. Wurster ,  Clarence Eugene Hull, III

Inventor： Steven W. Andrews ,  Michael E. Garst ,  Xialing Guo ,  Jonathan J. Hebert ,  Thomas Malone ,  Julie A. Wurster ,  Clarence Eugene Hull, III

IPC: A61K315355

CPC classification number: C07D403/06 ,  C07D209/34 ,  C07D405/04

Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell poliferation.

Abstract translation: 本发明涉及能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子。

公开(公告)号：US06395787B1

公开(公告)日：2002-05-28

申请号：US09500142

申请日：2000-02-08

Applicant: David F. Woodward ,  Helen H. Usansky ,  Steven W. Andrews ,  Robert M. Burk ,  June Chen ,  Achim H-P. Krauss ,  Cherukury Madhu

Inventor： David F. Woodward ,  Helen H. Usansky ,  Steven W. Andrews ,  Robert M. Burk ,  June Chen ,  Achim H-P. Krauss ,  Cherukury Madhu

IPC: A61K315575

CPC classification number: A61K9/0048 ,  C07C405/0041

Abstract: Compounds of Formula 1, where the symbols are as defined in the specification, are useful as ocular hypotensive agents but do not exert their activity through the FP prostaglandin receptor. In particular the compound PGF2&agr; 1-ethanolamide, having the formula was discovered to be present in mammalian tissue as a naturally occurring substance, was synthesized in a substantially pure form and was found to be effective for lowering intraocular pressure in the mammalian eye, but not acting through the FP receptor through which many ocular hypotensive prostaglandins act.

Abstract translation: 化学式1的化合物，其中符号如说明书中所定义，可用作眼部降压药，但不通过FP前列腺素受体发挥其活性。特别是具有发现存在于该药物中的福尔马林的化合物PGF2α1-乙醇酰胺 作为天然存在的物质的哺乳动物组织以基本上纯的形式被合成，并被发现对于降低哺乳动物眼睛中的眼内压而言是有效的，但不能通过多种眼部低血压前列腺素起作用的FP受体起作用。

公开(公告)号：US5607978A

公开(公告)日：1997-03-04

申请号：US371339

申请日：1995-01-11

Applicant: David F. Woodward ,  Steven W. Andrews ,  Robert M. Burk ,  Michael E. Garst

Inventor： David F. Woodward ,  Steven W. Andrews ,  Robert M. Burk ,  Michael E. Garst

IPC: A61K31/045 ,  A61K31/075 ,  A61K31/13 ,  A61K31/16 ,  A61K31/275 ,  A61K31/381 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  A61K31/655 ,  A61P1/00 ,  A61P1/16 ,  A61P9/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P27/02 ,  A61P27/06 ,  A61P27/14 ,  A61P37/08 ,  A61P43/00 ,  C07C35/21 ,  C07C35/50 ,  C07C69/732 ,  C07C69/734 ,  C07C205/17 ,  C07C215/42 ,  C07C235/34 ,  C07C247/10 ,  C07C255/36 ,  C07C405/00 ,  A61K31/135 ,  A61K31/34 ,  A61K31/38 ,  A61K31/44

CPC classification number: A61K31/559 ,  A61K31/381 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  C07C215/42 ,  C07C235/34 ,  C07C247/10 ,  C07C255/36 ,  C07C35/21 ,  C07C405/00 ,  C07C2101/08

Abstract: The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives, substituted in the 1-position with halo, methyl, hydroxyl, nitro, amino, amido, azido, oxime, cyano, thiol, either or thioether groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivatives. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivatives of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) derivatives of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.

Abstract translation: 本发明提供在1-位被卤素，甲基，羟基，硝基，氨基，酰氨基，叠氮基，肟，氰基，硫醇，或硫醚基取代的环戊烷庚酸，2-环烷基或芳基烷基衍生物，例如 1-OH环戊烷庚酸，2-（环烷基或芳基烷基）衍生物。 本发明的环戊烷庚酸，2-（环烷基或芳基烷基）衍生物是有效的眼睛低血压剂，特别适用于治疗青光眼。 此外，本发明的环戊烷庚酸，2-（环烷基或芳基烷基）衍生物是广泛应用于全身高血压和肺部疾病的平滑肌松弛剂; 平滑肌松弛剂适用于胃肠道疾病，繁殖，生育，失禁，休克等。