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11 条记录 (耗时 0.028 秒)

    Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors
    1.
    发明授权
    Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors 失效
    双环吡咯酰胺作为糖原磷酸化酶抑制剂

    公开(公告)号：US06399601B1

    公开(公告)日：2002-06-04

    申请号：US09670759

    申请日：2000-09-27

    申请人： Daisy Joe Du Bois

    发明人： Daisy Joe Du Bois

    IPC分类号： A61K315355

    CPC分类号： C07D491/04 ,  C07D209/52 ,  C07D495/04

    摘要： This invention relates to compounds of Formula I or stereoisomers, pharmaceutically acceptable salts or prodrugs thereof or a pharmaceutically acceptable salts of the prodrugs. This invention also relates to pharmaceutical compositions comprising a compound of Formula I, and to methods of treatment of diabetes, insulin resistance, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis, or tissue ischemia.

    摘要翻译： 本发明涉及式I或其立体异构体的化合物，其药学上可接受的盐或前药或其药学上可接受的盐。 本发明还涉及包含式I化合物的药物组合物和治疗糖尿病，胰岛素抵抗，糖尿病性神经病，糖尿病性肾病，糖尿病性视网膜病，白内障，高血糖症，高胆固醇血症，高血压，高胰岛素血症，高脂血症，动脉粥样硬化或组织的方法 缺血。

    Antithrombotic agents
    8.
    发明授权
    Antithrombotic agents 失效
    抗血栓药

    公开(公告)号：US06180627B2

    公开(公告)日：2001-01-30

    申请号：US09372200

    申请日：1999-08-11

    申请人： Julian Blagg ,  Alan Daniel Brown ,  Elisabeth Colette Louise Gautier ,  Julian Duncan Smith ,  Andrew Brian McElroy

    发明人： Julian Blagg ,  Alan Daniel Brown ,  Elisabeth Colette Louise Gautier ,  Julian Duncan Smith ,  Andrew Brian McElroy

    IPC分类号： A61K315355

    CPC分类号： C07D401/14 ,  A61K38/00 ,  C07D403/14 ,  C07K5/06139 ,  C07K5/06191

    摘要： Compounds of formula (I): Are antithrombotic agents, having utility in a variety of therapeutic areas including the prevention and/or treatment of deep vein thrombosis (DVT) after surgery, major medical illness, paralysis, malignancy, prolonged immobilisation trauma, application of lower limb plaster casts, or fractures of the lower limbs or pelvis; recurrent DVT; DVT during pregnancy when there is a previous history thereof; reocclusion following thrombolytic therapy; chronic arterial obstruction; peripheral vascular disease; acute myocardial infarction; unstable angina; atrial fibrillation; thrombotic stroke; transient ischaemic attacks; disseminated intravascular coagulation; coagulation in extra-corporeal circuits; occlusion of aterio-venous shunts and blood vessel grafts (including coronary artery by-pass grafts); and restenosis and occlusion following angioplasty.

    摘要翻译： 式（I）化合物：抗血栓形成剂，可用于各种治疗领域，包括手术后预防和/或治疗深静脉血栓形成（DVT），主要医学疾病，麻痹，恶性肿瘤，长期固定创伤，应用 下肢石膏或下肢或骨盆骨折; 复发DVT; 怀孕期间DVT有先前的病史; 溶栓治疗后再闭塞; 慢性动脉阻塞; 周边血管疾病; 急性心肌梗塞; 不稳定型心绞痛; 房颤; 血栓性脑卒中 短暂性脑缺血发作; 弥散性血管内凝血; 额外体内循环中的凝血; 静脉分流术和血管移植物（包括冠状动脉旁路移植物）的闭塞; 以及血管成形术后的再狭窄和闭塞。