公开(公告)号：US20230056782A1

公开(公告)日：2023-02-23

申请号：US17789796

申请日：2020-12-30

Applicant: Ming-Tain LAI ,  Jiann-Shiun LAI ,  Chiu-Chun LIN ,  I-Ju CHEN ,  Woan-Eng CHAN ,  OBI PHARMA, INC.

Inventor： MING-TAIN LAI ,  JIANN-SHIUN LAI ,  CHIU-CHUN LIN ,  I-JU CHEN ,  WOAN-ENG CHAN

IPC: C07K16/18 ,  A61P35/00

Abstract: The present invention provides antibodies or the antigen-binding portion thereof, that bind to stage-specific embryonic antigen 3 (SSEA-3) antigen. Also disclosed herein are pharmaceutical compositions and methods for the inhibition of cancer cells in a subject in need thereof. The pharmaceutical compositions include an antibody or an antigen-binding portion thereof and at least one pharmaceutically acceptable carrier.

公开(公告)号：US11236154B2

公开(公告)日：2022-02-01

申请号：US16547009

申请日：2019-08-21

Applicant: OBI PHARMA, INC.

Inventor： Cheng-Der Tony Yu ,  Jiann-Shiun Lai ,  I-Ju Chen

IPC: A61K39/395 ,  C07K16/18 ,  A61P35/00 ,  C07K16/44 ,  C07K16/30 ,  A61K39/00

Abstract: The present invention provides antibodies or the antigen-binding portion thereof to a tumor-associate carbohydrate antigen. Also disclosed herein are pharmaceutical compositions and methods for the inhibition of cancer cells in a subject in need thereof. The pharmaceutical compositions comprise an antibody or an antigen-binding portion thereof and at least one pharmaceutically acceptable carrier.

公开(公告)号：US10935544B2

公开(公告)日：2021-03-02

申请号：US15255996

申请日：2016-09-02

Applicant: OBI Pharma, Inc.

Inventor： Peiwen Yu ,  Wei-Chien Tang ,  Shu-Yi Lin ,  Cheng-Chi Wang

IPC: G01N33/574 ,  G01N33/53

Abstract: The invention relates to linkers and methods for generating arrays with linkers. The invention also relates to methods for identifying agents that bind to various types of molecules on the arrays and to defining the structural elements of the molecules on the arrays that bind to those agents. The arrays and methods provided herein may be used for epitope identification, drug discovery and as analytical tools. The invention provides useful glycans and epitope determinants that are useful in detecting, diagnosing, recurrence monitoring and preventing cancer.

公开(公告)号：US10829437B2

公开(公告)日：2020-11-10

申请号：US15563481

申请日：2016-04-01

Applicant: OBI PHARMA, INC. ,  ASCENTA PHARMACEUTICALS, LTD.

Inventor： Jian-Xin Duan ,  Yeyu Cao ,  Xiaohong Cai ,  Hailong Jiao ,  Jing Yuan Ma ,  Mark Matteucci

IPC: C07C217/58 ,  C07C213/02 ,  C07D405/12 ,  C07D491/22 ,  C07H19/06 ,  C07F9/6558 ,  A61K47/64 ,  C07D403/06 ,  A61K47/55 ,  A61P35/00 ,  C07D239/94 ,  C07D487/04 ,  C07D471/04 ,  A61K47/54

Abstract: Provided herein are compounds of formula I, wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.

公开(公告)号：US20200061169A1

公开(公告)日：2020-02-27

申请号：US16671395

申请日：2019-11-01

Applicant: OBI PHARMA, INC.

Inventor： Wei Han LEE ,  NAN-HSUAN WANG ,  CHUNG HAO CHANG ,  YIH-HUANG HSIEH ,  CHENG DER TONY YU ,  CHENG-CHI WANG ,  YU-HSIN LIN ,  YU-CHEN LIN ,  I-JU CHEN

IPC: A61K39/00 ,  C07H15/24 ,  A61K39/39

Abstract: The present invention provides vaccines comprising carbohydrate antigen conjugated to a diphtheria toxin (DT) as a carrier protein, wherein the ratio of the number of carbohydrate antigen molecule to the carrier protein molecule is higher than 5:1. Also disclosed herein is a novel saponin adjuvant and methods to inhibit cancer cells, by administering an effective amount of the vaccine disclose herein.

公开(公告)号：US20180134799A1

公开(公告)日：2018-05-17

申请号：US15824733

申请日：2017-11-28

Applicant: OBI PHARMA, INC.

Inventor： Cheng-Der Tony YU ,  Jiann-Shiun Lai ,  I-Ju Chen ,  Cheng-Chi Wang ,  Yi-Chien Tsai

IPC: C07K16/30

Abstract: The present invention provides antibodies or the antigen-binding portion thereof, that bind to one or more carbohydrate antigens. Also disclosed herein are pharmaceutical pharmaceutical compositions and methods for the inhibition of cancer cells in a subject in need thereof. The pharmaceutical compositions comprise an antibody or an antigen-binding portion thereof and at least one pharmaceutically acceptable carrier.

公开(公告)号：US20170101462A1

公开(公告)日：2017-04-13

申请号：US15288562

申请日：2016-10-07

Applicant: OBI PHARMA, INC.

Inventor： Cheng-Der Tony YU ,  Jiann-Shiun Lai ,  I-Ju Chen

IPC: C07K16/18

CPC classification number: C07K16/18 ,  A61K2039/505 ,  A61K2039/80 ,  A61P35/00 ,  C07K16/30 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/92

Abstract: The present invention provides antibodies or the antigen-binding portion thereof to a tumor-associate carbohydrate antigen. Also disclosed herein are pharmaceutical compositions and methods for the inhibition of cancer cells in a subject in need thereof. The pharmaceutical compositions comprise an antibody or an antigen-binding portion thereof and at least one pharmaceutically acceptable carrier.

公开(公告)号：US20170067885A1

公开(公告)日：2017-03-09

申请号：US15255996

申请日：2016-09-02

Applicant: OBI Pharma, Inc.

Inventor： Peiwen Yu ,  Wei-Chien Tang ,  Shu-Yi Lin ,  Cheng-Chi Wang

IPC: G01N33/53 ,  G01N33/574

CPC classification number: G01N33/5308 ,  G01N33/57484 ,  G01N33/57488 ,  G01N2400/02 ,  G01N2400/38 ,  G01N2500/04

Abstract: The invention relates to linkers and methods for generating arrays with linkers. The invention also relates to methods for identifying agents that bind to various types of molecules on the arrays and to defining the structural elements of the molecules on the arrays that bind to those agents. The arrays and methods provided herein may be used for epitope identification, drug discovery and as analytical tools. The invention provides useful glycans and epitope determinants that are useful in detecting, diagnosing, recurrence monitoring and preventing cancer.

Abstract translation: 本发明涉及用于利用链接器生成阵列的链接器和方法。 本发明还涉及用于鉴定结合阵列上的各种类型的分子的试剂的方法，并且限定结合这些试剂的阵列上的分子的结构元件。 本文提供的阵列和方法可用于表位鉴定，药物发现和分析工具。 本发明提供了可用于检测，诊断，复发监测和预防癌症的有用的聚糖和表位决定簇。

公开(公告)号：US20160339089A1

公开(公告)日：2016-11-24

申请号：US14855260

申请日：2015-09-15

Applicant: OBI PHARMA, INC.

Inventor： Cheng-Der Tony YU ,  Yih Huang HSIEH ,  I-Ju CHEN ,  Wei-Han LEE ,  Nan-Hsuan WANG

IPC: A61K39/00 ,  C07K16/18 ,  A61K39/385

CPC classification number: A61K39/0011 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/55577 ,  A61K2039/575 ,  A61K2039/6081 ,  A61K2039/627 ,  A61K2039/645 ,  C07K16/18 ,  C07K2317/10 ,  C07K2317/21

Abstract: The present disclosure encompasses immunogenic/therapeutic compositions including Globo H-KLH glycoconjugates (OBI-822) and/or therapeutic adjuvants (OBI-821/OBI-834) as well as methods of making and using the same to treat proliferative diseases such as cancer. The therapeutic conjugates include an antigen linked to a carrier. In particular the therapeutic conjugates include a Globo H moiety and a KLH moiety and/or a derivatized KLH moiety subunit optionally linked via a linker. The therapeutic compositions are in part envisaged to act as cancer vaccines for boosting the body's natural ability to protect itself, through the immune system from dangers posed by damaged or abnormal cells such as cancer cells. Exemplary immune response can be characterized by reduction of the severity of disease, including but not limited to, prevention of disease, delay in onset of disease, decreased severity of symptoms, decreased morbidity and delayed mortality.

Abstract translation: 本公开涵盖包括Globo H-KLH糖缀合物（OBI-822）和/或治疗性佐剂（OBI-821 / OBI-834）的免疫原性/治疗组合物以及制备和使用其来治疗增殖性疾病如癌症的方法 。 治疗性缀合物包括与载体连接的抗原。 特别地，治疗性缀合物包括Globo H部分和KLH部分和/或任选通过连接体连接的衍生的KLH部分亚基。 部分设想治疗组合物作为癌症疫苗，以通过免疫系统增强身体的自然保护能力，避免受损或异常细胞如癌细胞引起的危险。 可以通过降低疾病的严重程度来表征示例性的免疫应答，包括但不限于疾病的预防，疾病发作的延迟，症状的严重性降低，发病率和延迟的死亡率降低。