公开(公告)号：US20250011438A1

公开(公告)日：2025-01-09

申请号：US18667700

申请日：2024-05-17

Applicant: Institute for Basic Science

Inventor： Gou Young Koh ,  Jeomil Bae ,  Jaeryung Kim

IPC: C07K16/28 ,  A61K31/713 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P27/06 ,  C12N5/10 ,  C12N15/63

Abstract: The present invention refers to an antibody against Tie-2 or antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a manufacturing method of the antibody or antigen-binding fragment thereof, and a composition for preventing or treating angiogenic diseases, which comprises the antibody or antigen-binding fragment thereof.

公开(公告)号：US20240294945A1

公开(公告)日：2024-09-05

申请号：US18025446

申请日：2021-09-17

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin-Soo KIM ,  Kayeong LIM ,  Sung lk CHO ,  Beum-Chang KANG ,  Seonghyun LEE ,  Hyunji LEE ,  Young Geun MOK ,  Ji Min LEE ,  Eugene CHUNG

IPC: C12N15/90 ,  A61K48/00 ,  C12N9/22 ,  C12N9/78 ,  C12N15/10 ,  C12N15/82

CPC classification number: C12N15/90 ,  A61K48/005 ,  C12N9/22 ,  C12N9/78 ,  C12N15/102 ,  C12N15/82

Abstract: The present invention relates to a cytosine or adenine deaminase in an isolated form or a variant thereof, a non-toxic full-length cytosine deaminase or a variant thereof, a fusion protein comprising same, a composition for base editing, and a method for editing a base by using same.

公开(公告)号：US20240271117A1

公开(公告)日：2024-08-15

申请号：US18566904

申请日：2022-06-07

Applicant: INSTITUTE FOR BASIC SCIENCE ,  Ulsan National Institute of Science and Technology

Inventor： Yoon-Kyoung CHO ,  Kumar SUMMIT

IPC: C12N11/04 ,  C12N11/18

CPC classification number: C12N11/04 ,  C12N11/18

Abstract: The present invention relates to a nano-vesicle reactor and a method for producing the same. Specifically, the present invention provides a composition for producing a nano-vesicle reactor, characterized by comprising a first vesicle containing a first receptor on its surface and a second vesicle containing a second receptor on its surface, wherein the first receptor and the second receptor are bound with each other through a ligand system so that the first vesicle and the second vesicle are fused to form the nano-vesicle reactor; and a method for producing the above nano-vesicle reactor. The nano-vesicle reactor of the present invention can be utilized in production of energy inside a cell through cellular enzymatic reaction, a drug delivered system, and a diagnostic system.

公开(公告)号：US12049436B2

公开(公告)日：2024-07-30

申请号：US17536383

申请日：2021-11-29

Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyoyoung Lee ,  Suresh Vasimalla ,  Seungeun Lee

IPC: C07C231/10 ,  B01J21/06 ,  B01J35/39 ,  B01J37/16 ,  C01G23/08 ,  C07C233/65 ,  C07D295/192 ,  C07D401/04

CPC classification number: C07C231/10 ,  B01J21/063 ,  B01J35/39 ,  B01J37/16 ,  C01G23/08 ,  C07C233/65 ,  C07D295/192 ,  C07D401/04

Abstract: Provided is a preparing method of an amide directly from a tertiary amine by using a reduced titanium dioxide (Blue TiO2), which is formed by mixing a titanium dioxide having an anatase phase and a rutile phase with a reducing agent and selectively reducing any one of the anatase phase and the rutile phase, as a photocatalyst.

公开(公告)号：US11998901B2

公开(公告)日：2024-06-04

申请号：US17676078

申请日：2022-02-18

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sukbok Chang ,  Seung Youn Hong ,  Yoon Su Park ,  Yeongyu Hwang ,  Yeong Bum Kim

IPC: C07D207/267 ,  B01J31/22 ,  C07D209/34 ,  C07D209/46 ,  C07D209/52 ,  C07D209/54 ,  C07D209/56 ,  C07D209/70 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07F15/06 ,  C07F17/02 ,  C07J43/00

CPC classification number: B01J31/2295 ,  C07D207/267 ,  C07D209/46 ,  C07D209/52 ,  C07D209/54 ,  C07D209/56 ,  C07D209/70 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07F17/02 ,  C07J43/003 ,  B01J2231/60

Abstract: The present invention relates to a novel metal complex, a method for producing same, and a method for producing a gamma-lactam compound using same, and the metal complex according to the present invention is used as a catalyst for producing a gamma-lactam compound and can efficiently produce a gamma-lactam compound with an excellent yield and excellent selectivity.

公开(公告)号：US20240018492A1

公开(公告)日：2024-01-18

申请号：US18247108

申请日：2021-09-29

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin-Soo KIM ,  Chul-Yong PARK

IPC: C12N9/22 ,  C12N15/10 ,  C12N15/63 ,  C12N9/12

CPC classification number: C12N9/22 ,  C12N15/102 ,  C12N15/63 ,  C12N9/1276 ,  C12N2310/20 ,  C12Y207/07049

Abstract: The present invention relates to: a prime editing composition comprising a prime editor protein or a nucleic acid encoding same, and a prime editing guide RNA (pegRNA); and a prime editing method.

公开(公告)号：US20230256417A1

公开(公告)日：2023-08-17

申请号：US18110028

申请日：2023-02-15

Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyoyoung Lee ,  Jung Sue CHOI ,  Hak Sung LEE ,  Yeon Su HAN ,  Tae Hun YANG ,  Hyun KO

IPC: B01J23/30 ,  B01J21/06 ,  B01J31/06 ,  B01J31/38 ,  B01J35/00 ,  B01J37/04 ,  B01J37/00 ,  B01J37/02 ,  A61L9/20 ,  B01D53/86 ,  B01D53/00 ,  B01D53/88

CPC classification number: B01J23/30 ,  B01J21/063 ,  B01J31/061 ,  B01J31/38 ,  B01J35/0013 ,  B01J37/04 ,  B01J37/0018 ,  B01J37/0219 ,  B01J37/0217 ,  A61L9/20 ,  B01D53/8668 ,  B01D53/007 ,  B01D53/885 ,  A61L2209/12 ,  A61L2209/14 ,  B01D2255/20707 ,  B01D2255/20776 ,  B01D2255/802 ,  B01D2257/708 ,  B01D2259/804 ,  B01D2255/915

Abstract: The present application relates to a filter having a photocatalyst attached thereto, which comprises: a substrate; and a photocatalyst bonded on the substrate, in which the photocatalyst has each photocatalyst bonded and combined by a polymer binder, and the substrate and the photocatalyst are bonded by a hydrophilic polymer binder.

公开(公告)号：US20220259748A1

公开(公告)日：2022-08-18

申请号：US17588597

申请日：2022-01-31

Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyoyoung LEE ,  Jadhav Amol

IPC: C25B11/053 ,  C25B1/04

Abstract: The present application relates to an electrode catalyst for water electrolysis including a first transition metal foam, a metal layered double hydroxide (LDH)/metal oxide mixed layer which contains a second transition metal and a third transition metal that are formed on the surface of the first transition metal foam, and fourth transition metal oxyhydroxide nanoparticles formed on the surface of the mixed layer, in which the mixed layer surface contains the metal layered double hydroxide.

公开(公告)号：US20220243343A1

公开(公告)日：2022-08-04

申请号：US17585021

申请日：2022-01-26

Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyoyoung LEE ,  Yang LIU

IPC: C25B11/093 ,  C25B1/04 ,  C25B9/17

Abstract: Summary
The present application relates to a catalyst for hydrogen evolution reaction (HER) including a transition metal matrix and noble metal atoms formed in the transition metal matrix, in which the noble metal atoms have oxygen adsorbed thereto, and oxygen is derived from the transition metal matrix.

公开(公告)号：US20220205118A1

公开(公告)日：2022-06-30

申请号：US17560979

申请日：2021-12-23

Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyoyoung LEE ,  Jinsun LEE ,  Ashwani KUMAR

IPC: C25B11/073 ,  C25B1/04 ,  C25B11/054

Abstract: The present disclosure relates to a water splitting catalyst including a porous carbon layer, a bimetallic metal alloy core dispersed on the porous carbon layer, and a single-atom precious metal dispersed on the bimetallic metal alloy core, in which oxygen is adsorbed on the surface of the bimetallic metal alloy core.