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公开(公告)号：US20220099686A1
公开(公告)日：2022-03-31
申请号：US17426936
申请日：2019-11-29
发明人： Ji Sook MOON
IPC分类号： G01N33/68
摘要： Provided are a brain-derived vesicle-specific marker and a brain disease diagnostic method using the same. According to one aspect, by using a marker which specifically expresses in brain-derived vesicles, brain-derived vesicles may be isolated in a highly efficient and highly specific manner without having to collect tissue, and vesicles which specifically express in each region of the brain may be isolated. Also, a brain disease condition may be diagnosed by means of an expression profile of a marker specific to a brain region in brain-derived vesicles which have been isolated by means of the marker according to one aspect.
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52.发明申请公开(公告)号：US20210395680A1
公开(公告)日：2021-12-23
申请号：US17290085
申请日：2019-10-23
发明人： Dong Youn HWANG
IPC分类号： C12N5/0793
摘要： Provided are a composition and a kit for differentiation of stem cells into neural progenitor cells (NPCs), each including a protein kinase C (PKC) inhibitor and a bone morphogenic protein (BMP) inhibitor, and a method using the same. Accordingly, stem cells may be efficiently differentiated into neural progenitor cells using a simple, low-cost composition.
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公开(公告)号：US20210324475A1
公开(公告)日：2021-10-21
申请号：US17285370
申请日：2019-09-17
发明人： Kwang-Hyun BAEK , Soo-Ji KANG
IPC分类号： C12Q1/6883 , G01N33/68
摘要： Provided is an analytical method for providing information necessary for a diagnosis of alcohol use disorder, including measuring (i) an expression level of a gene encoding a JNK or p-JNK protein in a subject's sample, (ii) an expression level of a gene encoding a JNK or p-JNK protein and an expression level of a gene encoding the Elk-1 protein in a subject's sample, or (iii) expression levels of genes encoding JNK, p-JNK, and Elk-1 proteins in a subject's sample, respectively; and a kit for a diagnosis of alcohol use disorder which is used in the analytical method.
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公开(公告)号：US20210057110A1
公开(公告)日：2021-02-25
申请号：US17052464
申请日：2019-05-02
发明人： Hyun Wook HAN , Jong Man YU , Dong Hyun LEE , Ho YUN , Tae Sun HWANG , Chaewon LEE , Kanghyun KIM , Sangmin NAM
IPC分类号： G16H50/80 , G16H50/70 , G16H20/10 , G16H10/60 , G16H50/30 , G06Q40/08 , G06Q50/26 , G16H70/60 , G16H15/00
摘要： A disease network construction method includes the steps of: (1) organizing cohort data in time series; (2) stratifying or grouping the data organized in step (1) by confounding variables; (3) deriving a correlation of diseases within the stratification in step (2); and (4) constructing a disease network on the basis of the correlation derived in step (3). According to the present invention, a disease may be influenced by a variety of clinical and medical confounding variables such as age, gender, race, socioeconomic variables, and regional and national health care systems, and thus a method for more reliably deriving a correlation between diseases may be provided.
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公开(公告)号：US20200239853A1
公开(公告)日：2020-07-30
申请号：US16811086
申请日：2020-03-06
发明人： Dong Ryul LEE , Dong Won Seol
摘要： Provided are stem cells-induced Serotoli-like cells, methods of preparing the same, and uses thereof. Sertoli-like cells according to one embodiment can be differentiated from embryonic stem cells with excellent proliferative capacity, and thus, can be obtained in large quantities. Also, since the Sertoli-like cells secrete immunosuppressive substances and form immune privilege and induce anti-inflammatory functions, they can be used for development of the cell therapeutic agent.
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56.发明申请公开(公告)号：US20200215232A1
公开(公告)日：2020-07-09
申请号：US16824222
申请日：2020-03-19
发明人： Ae Ri KIM , Seong Hee JEONG
摘要： The present disclosure provides a coacervate composition containing a protein drug, gelatin A, sodium alginate and an acid and a wound-healing agent including the same. The coacervate composition according to the present disclosure can be useful as a wound-healing material delivery system for effectively delivering a protein drug, particularly epidermal growth factor, to a wound site in the wound-healing field.
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57.发明申请公开(公告)号：US20190194591A1
公开(公告)日：2019-06-27
申请号：US16167922
申请日：2018-10-23
发明人： Surin HONG , Yong Soo CHOI
CPC分类号： C12M25/16 , C12N5/0018 , C12N2501/11 , C12N2501/115 , C12N2501/125 , C12N2501/13 , C12N2501/165 , C12N2501/22 , C12N2501/2302 , C12N2501/2304 , C12N2501/2306 , C12N2501/24 , C12N2533/10 , C12N2533/32 , C12N2533/52 , C12N2533/54 , C12N2533/56 , C12N2533/90
摘要： Provided are a support for culturing cells, a method of preparing the support, and a method of culturing cells using the support. When the support and the methods are used, an adherence rate, a surface area, and a proliferation rate of cells may improve, and detachment of the cells may be facilitated, thereby increasing a cell recovery rate. In addition, a physiologically active substance may be slowly released, thereby reducing the cost for a cell culture process.
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公开(公告)号：US20190021976A1
公开(公告)日：2019-01-24
申请号：US15809042
申请日：2017-11-10
申请人： SUNGKWANG MEDICAL FOUNDATION , College of Medicine Pochon CHA University Industry-Academic Cooperation Foundation
发明人： David Tae Aug KIM , Dong Hyun Kim , A-Ram Kim
摘要： The present invention relates to a photoaging inhibitor, and more specifically it relates to a pharmaceutical composition, a food composition or a cosmetic composition for preventing, improving or treating photoaging of skin, comprising DHPV (5-(3′,4′-Dihydroxyphenyl)-Γ-valerolactone) which is a metabolite of cacao. Since DHPV, an active ingredient comprised in the composition according to the present invention is a metabolite of cacao which is a botanical raw material harmless to human body and is not only excellent in biosafety, but also regulates expression of proteins related to skin aging epigenetically, thereby exhibiting an excellent skin aging-preventing function at a low concentration of 1 nM based on skin cells, the composition comprising the same is excellent in use as medicines, cosmetics and foods for preventing, improving and treating skin aging.
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公开(公告)号：US20170296582A1
公开(公告)日：2017-10-19
申请号：US15518184
申请日：2014-10-10
发明人： Ji-Sook MOON , Hyun-Seob LEE , Yeon-Ho SHIN
CPC分类号： A61K35/12 , A61K35/00 , C12N5/0018 , C12N5/06 , C12N5/0603 , C12N5/0618 , C12N2500/02 , C12N2500/38 , C12N2501/11 , C12N2501/115 , C12N2533/32 , C12N2533/52
摘要： The present invention provides a method for proliferating neural progenitor cells and a composition for treating neurological diseases, the composition including a proliferated neural progenitor cell. When a fetal neural progenitor cell is cultured under a hypoxia condition and/or in a medium containing tocoperol, tocoperol acetate, or a mixture thereof, the improved cell proliferation rates of the fetal neural progenitor cell are confirmed. In addition, considering an effect of the neural progenitor cell on preventing differentiation thereof into neurons at the time of proliferation, the present disclosure may contribute to mass production of neural stem cells, and accordingly, the proliferated neural progenitor cell is expected to be utilized in the treatment of a neurological disease.
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