公开(公告)号：US11602757B2

公开(公告)日：2023-03-14

申请号：US16341436

申请日：2017-10-13

Applicant: Randox Laboratories Ltd.

Inventor： Stuart Jackson ,  Stephen Peter Fitzgerald ,  Ivan McConnell ,  John Lamont

IPC: B01F33/452 ,  C12N15/10 ,  B03C1/01 ,  B03C1/28 ,  B01F101/23

Abstract: There is provided a method of extracting material from a fluid method of extracting material from a fluid, the fluid being held within a fluid chamber. The method comprises drawing, with a magnetic field generating system, at least one magnetically susceptible member through the fluid around a closed path between at least three points in the chamber, said at least one member being adapted to bind to material in fluid in the chamber. The at least three points are arranged relative to each other in a shape having at least two dimensions, the magnetic field generating system being configured to move the at least on magnetically susceptible member directly between the at least three points, material in the fluid binding to the at least one magnetically susceptible member when it comes into contact with the at least one member as it moves through the fluid.

公开(公告)号：US20220349882A1

公开(公告)日：2022-11-03

申请号：US17630101

申请日：2020-07-26

Applicant: Randox Laboratories Ltd ,  Randox Teoranta

Inventor： Peter Fitzgerald ,  Ivan McConnell ,  Ciaran Richardson ,  John Lamont

IPC: G01N33/543 ,  G01N33/569

Abstract: The current invention provides a multiplex method for screening bovine samples for antibodies against several important pathogens. These pathogens include Bovine Viral Diarrhoea Virus (BVDV), Bovine Herpesvirus-1 (BoHV-1), Mycobacterium paratuberculosis (MAP), Leptospira species, Neospora caninum and Fasciola hepatica. This multiplex screening is enabled by substrates with immobilized pathogen antigens and offer multiple advantages for the routine testing of farm animals.

公开(公告)号：US20220011311A1

公开(公告)日：2022-01-13

申请号：US17294358

申请日：2019-11-15

Applicant: Randox Laboratories Ltd.

Inventor： Mark Ruddock ,  John Lamont ,  Stephen Fitzgerald ,  Kathleen Williamson

IPC: G01N33/574

Abstract: The present invention provides a method for detecting the presence or risk of bladder cancer in a female patient comprising the steps of detecting the presence of a panel of biomarkers in a sample isolated from a female patient, said panel of biomarkers comprising IL-13 and IL-12p70 and one or more biomarkers selected from BTA, Midkine, PAI-1/tPA, 8OHdG, CEA, CK18, Clusterin, Creatinine, CXCL16, Cystatin B, Cystatin C, d-Dimer, EGF, FAS, HAD, IL-1a, IL-1b, IL-4, IL-6, IL-7, IL-8, MCP-1, Microalbumin, MMP9NGAL, MMP9TIMP1, NGAL, NSE, Progranulin, TUP, TGFB1, Thrombomodulin, sTNFR1, TPA, VEGF and Triglycerides and/or the concentration of albumin/microalbumin/protein and creatinine expressed as an albumin:creatinine ratio in a sample isolated from a female patient; and assessing the results and comparing them to a normal control wherein an elevated presence of the biomarker compared to a normal control indicates the presence or risk of cancer in the patient from whom the sample is isolated.

公开(公告)号：US20210316312A1

公开(公告)日：2021-10-14

申请号：US17265441

申请日：2019-08-02

Applicant: RANDOX LABORATORIES LTD

Inventor： Paul Courtney ,  Martin Reid ,  Stuart Jackson ,  John Lamont ,  Ivan McConnell ,  Peter Fitzgerald

IPC: B01L9/00 ,  B01L1/00

Abstract: There is provided a pipette tip disposal assembly. The assembly comprises a receiving element adapted to support an end of at least one pipette tip, the at least one pipette tip being toppled in use from the receiving element along a first direction; and a container positioned to receive the at least one toppled pipette tip, the at least one pipette tip falling towards a base of the container on being received by the container. The base of the container has a first linear dimension aligned with the first direction corresponding to the length of a pipette tip.

公开(公告)号：US20210299655A1

公开(公告)日：2021-09-30

申请号：US17265434

申请日：2019-08-02

Applicant: RANDOX LABORATORIES LTD

Inventor： David Sloan ,  Stuart Jackson ,  John Lamont ,  Ivan McConnell ,  Peter Fitzgerald

IPC: B01L3/00

Abstract: A cartridge for polymerase chain reaction, PCR, comprises a vessel for PCR having an opening and a resealable membrane arranged, in use, to cover the opening of the vessel such that the opening of the vessel is vapour tight.

公开(公告)号：US10914745B2

公开(公告)日：2021-02-09

申请号：US15457297

申请日：2017-03-13

Applicant: Randox Laboratories Ltd.

Inventor： John Lamont ,  Ivan McConnell ,  Peter Fitzgerald

IPC: G01N33/68 ,  C12Q1/6883

Abstract: The present invention provides biomarker-based methods for diagnosing stroke in a patient suspected of having suffered a stroke, and also for discriminating between ischemic stroke and transient ischemic attack. Substrates comprising probes for specific combinations of biomarkers useful in the methods of the invention are also described.

公开(公告)号：US10753948B2

公开(公告)日：2020-08-25

申请号：US14895724

申请日：2014-06-04

Applicant: Randox Laboratories Ltd.

Inventor： Ivan McConnell ,  John Lamont ,  Peter Fitzgerald ,  Konstantinos Makris

IPC: G01N33/68

Abstract: The present invention provides a method of aiding the differential diagnosis of haemorrhagic stroke, ischemic stroke and a transient ischemic attack in a patient who has suffered or is suffering a stroke. The method comprises: (i) determining the concentration of the biomarkers VCAM-1, GFAP and CRP in an ex vivo sample obtained from the patient; and (ii) establishing the statistical significance of the concentration of the biomarkers. Optionally, the method further comprises steps of (iii) determining the concentration of the biomarkers IL-6 and sTNFR1 in an ex vivo sample obtained from the patient; (iv) determining the gender of the patient; and (v) establishing the statistical significance of the concentration of the five biomarkers, in conjunction with the patient's gender. The present invention also provides substrates comprising probes for VCAM-1, GFAP and CRP for use in a method for aiding the differential diagnosis of stroke.

公开(公告)号：US10444248B2

公开(公告)日：2019-10-15

申请号：US14421382

申请日：2013-08-12

Applicant: Randox Laboratories Ltd.

Inventor： Ivan McConnell ,  Stephen Peter Fitzgerald ,  John Lamont ,  Claran Richardson

IPC: G01N33/48 ,  G01N33/68 ,  C12N9/10 ,  G01N33/70 ,  G01N33/92 ,  C07K14/81 ,  C07K14/475 ,  G01N33/573

Abstract: The present invention provides a method of stratifying a patient suffering from CKD into one of stages 1-3 of CKD, comprising determining the level of the biomarkers FABP1, γ-GT, AST, creatinine and cystatin C in a sample obtained from the patient and comparing the level of FABP1 in the sample to a control value and the levels of γ-GT, AST, creatinine and cystatin C in the sample to a range of control values for each biomarker, wherein an increased level of FABP1 compared to the control value and levels of γ-GT, AST, creatinine and cystatin C within the range of control values for each biomarker indicate that the patient suffers from stage 1 CKD or wherein an increased level of FABP1 compared to the control value, levels of γ-GT and AST within the range of control values for each biomarker, and increased levels of creatinine and cystatin C compared to an upper threshold of the control range for these biomarkers indicate that the patient suffers from stage 2 or stage 3 CKD.

公开(公告)号：US09880178B2

公开(公告)日：2018-01-30

申请号：US14431557

申请日：2013-10-03

Applicant: Randox Laboratories Ltd.

Inventor： Ellen Umlauf ,  Maria Zellner

IPC: G01N33/53 ,  G01N33/567 ,  G01N33/68 ,  G06F19/18 ,  G06F19/00

CPC classification number: G01N33/6896 ,  G01N2333/4712 ,  G01N2333/775 ,  G01N2333/90 ,  G01N2333/90638 ,  G01N2333/91085 ,  G01N2800/2821 ,  G06F19/18 ,  G16H50/20

Abstract: The present invention provides an ex vivo method for aiding the diagnosis of Alzheimer's disease in a patient comprising: (i) determining the number of alleles of ApoE4 in the patient's genome; (ii) determining the combined expression level of at least three platelet proteins in a platelet sample from the patient; and (iii) comparing the resulting value of step (ii) to a control value, wherein the at least three platelet proteins include at least one isoform of alpha-tropomyosin containing exon 1a and at least two platelet proteins selected from monoamine oxidase-B, coagulation factor XIIIa, wild-type GSTO-1 or mutant GSTO-1, wherein a result higher than the control value is indicative of Alzheimer's disease.The invention also provides a solid support comprising one or more ligands of at least one isoform of alpha-tropomyosin containing exon 1a, and one or more ligands of at least two platelet proteins selected from monoamine oxidase-B, coagulation factor XIIIa, wild-type GSTO-1 protein and/or mutant GSTO-1 protein immobilized thereon.

公开(公告)号：US09766109B2

公开(公告)日：2017-09-19

申请号：US13821846

申请日：2011-08-05

Applicant: Ian Armstrong ,  Michael Duffy ,  Stephen Peter Fitzgerald

Inventor： Ian Armstrong ,  Michael Duffy ,  Stephen Peter Fitzgerald

IPC: G01F23/26 ,  G01F25/00 ,  H03K17/955

CPC classification number: G01F23/261 ,  G01F23/265 ,  G01F23/266 ,  G01F25/0061 ,  H03K17/955 ,  H03K2217/94026

Abstract: A capacitive liquid level sensor is provided comprising a capacitive probe having a capacitance and comprising a sensing tip wherein the capacitive probe is configured such that the capacitance of the probe changes when the sensing tip is exposed to liquid. A signal generator operates to supply an electrical signal alternating between a high and low state to the capacitive probe, the electrical signal being configured such that the probe is alternately charged and discharged when the signal is high or low respectively. A comparator operates to detect the magnitude of an electrical signal across the capacitive probe and provides a first output signal value when the detected signal magnitude is greater than a predetermined threshold value and a second output signal value when the signal magnitude is less than the threshold value. A timer operates to receive an output signal from the comparator and measures a time period starting when the comparator output signal transitions to the first output signal value and ending when the comparator output signal transitions to the second output signal value. Liquid detection means also operate to utilize the time period measured by the timer to determine if the sensing tip is exposed to liquid.