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41.发明授权Cyclic diaryl ether compounds as antagonists of prostaglandin D2 receptors 失效环状二芳基醚化合物作为前列腺素D2受体的拮抗剂公开(公告)号：US08242145B2
公开(公告)日：2012-08-14
申请号：US12867476
申请日：2009-02-12
申请人： John Howard Hutchinson , Thomas Jonathan Seiders , Brian Andrew Stearns , Bowei Wang , Yen Pham Truong , Jeannie M. Arruda
发明人： John Howard Hutchinson , Thomas Jonathan Seiders , Brian Andrew Stearns , Bowei Wang , Yen Pham Truong , Jeannie M. Arruda
IPC分类号： A61K31/195 , A61K31/4418 , C07D213/64 , C07D229/00
CPC分类号： C07D233/32 , C07D207/38 , C07D263/22 , C07D263/52 , C07D413/12 , C07D417/12
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述的PGD 2受体的拮抗剂的药物组合物和药物，以及将PGD2受体单独和与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2的方法 介导的病症或疾病。
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公开(公告)号：US20110021573A1
公开(公告)日：2011-01-27
申请号：US12918043
申请日：2009-02-25
申请人： John Howard Hutchinson , Brian Andrew Stearns , Thomas Jonathan Seiders , Jill Melissa Scott , Jeannie M. Arruda , Bowei Wang
发明人： John Howard Hutchinson , Brian Andrew Stearns , Thomas Jonathan Seiders , Jill Melissa Scott , Jeannie M. Arruda , Bowei Wang
IPC分类号： A61K31/4439 , A61K31/423 , A61K31/421 , A61K31/4166 , A61K31/4174 , C07D413/10 , C07D263/58 , C07D263/22 , C07D233/74 , C07D233/26 , A61P9/10 , A61P19/02 , A61P35/00 , A61P9/12 , A61P17/02 , A61P17/06 , A61P11/14 , A61P11/06
CPC分类号： C07D285/04 , C07D233/06 , C07D263/22 , C07D263/52
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述的PGD 2受体的拮抗剂的药物组合物和药物，以及将PGD2受体单独和与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2的方法 介导的病症或疾病。
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公开(公告)号：US09090573B2
公开(公告)日：2015-07-28
申请号：US13498491
申请日：2010-10-01
申请人： Thomas J Seiders , Lucy Zhao , Jeannie Arruda , Bowei Wang , Brian Andrew Stearns , Yem Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Ryan Clark , Heather Renee Coate , Nicholas Simon Stock , Deborah Volkots
发明人： Thomas J Seiders , Lucy Zhao , Jeannie Arruda , Bowei Wang , Brian Andrew Stearns , Yem Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Ryan Clark , Heather Renee Coate , Nicholas Simon Stock , Deborah Volkots
IPC分类号： C07D495/04 , C07D417/12 , C07D413/06 , C07D413/12 , C07D261/08 , C07D261/14 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4725 , A61K31/4709 , A61K31/519
CPC分类号： C07D261/08 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/519 , C07D261/14 , C07D261/18 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D495/04
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号：US20120289522A1
公开(公告)日：2012-11-15
申请号：US13498491
申请日：2010-10-01
申请人： Thomas J. Seiders , Lucy Zhao , Jeannie Arruda , Bowei Wang , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Ryan Clark , Heather Renee Coate , Nicholas Simon Stock , Deborah Volkots
发明人： Thomas J. Seiders , Lucy Zhao , Jeannie Arruda , Bowei Wang , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Ryan Clark , Heather Renee Coate , Nicholas Simon Stock , Deborah Volkots
IPC分类号： A61K31/42 , C07D261/08 , C07D413/12 , A61K31/4439 , C07D417/12 , A61P17/00 , C07D495/04 , A61K31/519 , A61P11/00 , A61P13/12 , A61P1/16 , C07D261/14 , A61K31/428
CPC分类号： C07D261/08 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/519 , C07D261/14 , C07D261/18 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D495/04
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
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公开(公告)号：US09260416B2
公开(公告)日：2016-02-16
申请号：US13476607
申请日：2012-05-21
IPC分类号： C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , C07D417/14
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
摘要： Described herein are compounds that are inhibitors of autotaxin. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such inhibitors, alone and in combination with other compounds, for treating autotaxin-dependent or autotaxin-mediated conditions or diseases.
摘要翻译： 本文描述的是作为自分生素抑制剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及将这些抑制剂单独使用并与其它化合物组合用于治疗自体素受体依赖性或自体素介素介导的病症或疾病的方法。
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公开(公告)号：US20130029948A1
公开(公告)日：2013-01-31
申请号：US13476607
申请日：2012-05-21
IPC分类号： A61K31/4439 , C07D401/14 , A61P29/00 , A61K31/56 , A61P35/00 , A61P19/02 , A61P11/06 , A61P13/12 , A61P35/02 , A61P35/04 , A61P37/06 , A61P9/10 , C07D401/12 , A61P11/00
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
摘要： Described herein are compounds that are inhibitors of autotaxin. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such inhibitors, alone and in combination with other compounds, for treating autotaxin-dependent or autotaxin-mediated conditions or diseases.
摘要翻译： 本文描述的是作为自分生素抑制剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及将这些抑制剂单独使用并与其它化合物组合用于治疗自体素受体依赖性或自体素介素介导的病症或疾病的方法。
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公开(公告)号：US08426449B2
公开(公告)日：2013-04-23
申请号：US12935253
申请日：2009-03-25
IPC分类号： A01N43/40 , C07D213/62 , C07D229/00
CPC分类号： C07C233/62 , C07C217/58 , C07C233/18 , C07C233/43 , C07C233/73 , C07C271/16 , C07C271/20 , C07C271/24 , C07C311/08 , C07C311/17 , C07C311/29 , C07C311/40 , C07C317/14 , C07C2601/02 , C07C2602/08
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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48.发明申请LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CONDITIONS OR DISEASES OF THE EYE 审中-公开用于治疗眼睛病情或疾病的赖氨酸磷酸受体拮抗剂公开(公告)号：US20130253019A1
公开(公告)日：2013-09-26
申请号：US13704276
申请日：2011-06-13
IPC分类号： A61K31/42 , A61K31/4245
CPC分类号： A61K31/42 , A61K31/4245 , A61K31/74
摘要： Described herein is the use of LPA1 antagonists in the treatment or prevention of diseases or conditions of the eye of a mammal. Also described are pharmaceutical compositions that include at least one LPA1 antagonist.
摘要翻译： 本文描述了LPA1拮抗剂在治疗或预防哺乳动物眼睛疾病或病症中的用途。 还描述了包含至少一种LPA1拮抗剂的药物组合物。
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公开(公告)号：US20110130453A1
公开(公告)日：2011-06-02
申请号：US12935253
申请日：2009-03-25
IPC分类号： A61K31/195 , C07C233/22 , C07C271/16 , C07C317/14 , A61K31/27 , A61P11/06 , A61P17/00 , A61P11/00 , A61P19/02 , A61P17/06 , A61P9/10 , A61P17/02 , A61P35/00 , A61P29/00 , A61P37/08
CPC分类号： C07C233/62 , C07C217/58 , C07C233/18 , C07C233/43 , C07C233/73 , C07C271/16 , C07C271/20 , C07C271/24 , C07C311/08 , C07C311/17 , C07C311/29 , C07C311/40 , C07C317/14 , C07C2601/02 , C07C2602/08
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US07795274B2
公开(公告)日：2010-09-14
申请号：US12131828
申请日：2008-06-02
IPC分类号： A61K31/4427 , C07D471/04 , A61P29/00
CPC分类号： C07D491/02 , C07D471/04 , C07D498/02
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
摘要翻译： 本文描述了含有调节5-脂氧合酶活化蛋白（FLAP）的活性的化合物的化合物和药物组合物。 本文还描述了使用这样的FLAP调节剂单独和与其它化合物组合用于治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症或疾病的方法。
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