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公开(公告)号：US08664220B2
公开(公告)日：2014-03-04
申请号：US13499052
申请日：2010-09-29
申请人： Ryan Clark , Brian Andrew Stearns , Jill Melissa Scott , Heather Renee Coate , Lucy Zhao , Thomas J. Seiders , Deborah Volkots , Jeannie Arruda , Nicholas Simon Stock , Yen Pham Truong , David Nathan Zalatan
发明人： Ryan Clark , Brian Andrew Stearns , Jill Melissa Scott , Heather Renee Coate , Lucy Zhao , Thomas J. Seiders , Deborah Volkots , Jeannie Arruda , Nicholas Simon Stock , Yen Pham Truong , David Nathan Zalatan
IPC分类号： A61K31/42 , C07D261/14
CPC分类号： C07D231/38 , C07D261/08 , C07D261/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号：US09090573B2
公开(公告)日：2015-07-28
申请号：US13498491
申请日：2010-10-01
申请人： Thomas J Seiders , Lucy Zhao , Jeannie Arruda , Bowei Wang , Brian Andrew Stearns , Yem Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Ryan Clark , Heather Renee Coate , Nicholas Simon Stock , Deborah Volkots
发明人： Thomas J Seiders , Lucy Zhao , Jeannie Arruda , Bowei Wang , Brian Andrew Stearns , Yem Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Ryan Clark , Heather Renee Coate , Nicholas Simon Stock , Deborah Volkots
IPC分类号： C07D495/04 , C07D417/12 , C07D413/06 , C07D413/12 , C07D261/08 , C07D261/14 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4725 , A61K31/4709 , A61K31/519
CPC分类号： C07D261/08 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/519 , C07D261/14 , C07D261/18 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D495/04
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号：US20110312974A1
公开(公告)日：2011-12-22
申请号：US13121398
申请日：2009-09-28
申请人： John Howard Hutchinson , Brian Andrew Stearns , Nicholas Simone Stock , Yen Pham Truong , Jeffrey Roger Roppe , Deborah Volkots , Jill Melissa Scott , Timothy Andrew Parr , Bowei Wang , Thomas Jon Seiders , Ryan Clark , Heather Renee Coate
发明人： John Howard Hutchinson , Brian Andrew Stearns , Nicholas Simone Stock , Yen Pham Truong , Jeffrey Roger Roppe , Deborah Volkots , Jill Melissa Scott , Timothy Andrew Parr , Bowei Wang , Thomas Jon Seiders , Ryan Clark , Heather Renee Coate
IPC分类号： A61K31/497 , C07D401/10 , C07D401/12 , A61K31/44 , A61K31/4439 , A61K31/513 , A61K31/444 , A61P11/06 , A61P29/00 , A61P11/00 , A61P9/12 , A61P19/02 , A61P37/08 , A61P17/06 , A61P9/10 , A61P9/00 , A61P35/00 , A61P43/00 , A61P11/08 , A61P11/12 , A61P11/02 , A61P7/10 , A61P11/14 , C07D213/55
CPC分类号： C07D213/55 , C07D213/56 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/89 , C07D401/10 , C07D401/12
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用PGD2受体单独和与其它化合物组合的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症的方法 或疾病。
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公开(公告)号：US20130072490A1
公开(公告)日：2013-03-21
申请号：US13499052
申请日：2010-09-29
申请人： Ryan Clark , Brian Andrew Stearns , Jill Melissa Scott , Heather Renee Coate , Lucy Zhao , Thomas Jon Seiders , Deborah Volkots , Jeannie Arruda , Nicholas Simon Stock , Yen Pham Truong , David Nathan Zalatan
发明人： Ryan Clark , Brian Andrew Stearns , Jill Melissa Scott , Heather Renee Coate , Lucy Zhao , Thomas Jon Seiders , Deborah Volkots , Jeannie Arruda , Nicholas Simon Stock , Yen Pham Truong , David Nathan Zalatan
IPC分类号： A61K31/42 , C07D413/14 , C07D413/04 , C07D261/14 , C07D413/06 , C07D261/06
CPC分类号： C07D231/38 , C07D261/08 , C07D261/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号：US20120289522A1
公开(公告)日：2012-11-15
申请号：US13498491
申请日：2010-10-01
申请人： Thomas J. Seiders , Lucy Zhao , Jeannie Arruda , Bowei Wang , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Ryan Clark , Heather Renee Coate , Nicholas Simon Stock , Deborah Volkots
发明人： Thomas J. Seiders , Lucy Zhao , Jeannie Arruda , Bowei Wang , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Ryan Clark , Heather Renee Coate , Nicholas Simon Stock , Deborah Volkots
IPC分类号： A61K31/42 , C07D261/08 , C07D413/12 , A61K31/4439 , C07D417/12 , A61P17/00 , C07D495/04 , A61K31/519 , A61P11/00 , A61P13/12 , A61P1/16 , C07D261/14 , A61K31/428
CPC分类号： C07D261/08 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/519 , C07D261/14 , C07D261/18 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D495/04
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
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