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142 条记录 (耗时 0.047 秒)

    Morpholine containing pyridine compounds, compositions and use
    41.
    发明授权
    Morpholine containing pyridine compounds, compositions and use 失效
    含有吡啶化合物的吗啉，组成和用途

    公开(公告)号：US4857527A

    公开(公告)日：1989-08-15

    申请号：US184195

    申请日：1988-04-21

    申请人： Takao Takaya ,  Hisashi Takasugi ,  Kimio Esumi ,  Atsushi Kuno ,  Hiroyoshi Sakai ,  Kazuhiro Maeda ,  Yoshie Sakamoto

    发明人： Takao Takaya ,  Hisashi Takasugi ,  Kimio Esumi ,  Atsushi Kuno ,  Hiroyoshi Sakai ,  Kazuhiro Maeda ,  Yoshie Sakamoto

    IPC分类号： C07D213/82

    CPC分类号： C07D213/82

    摘要： An N-containing heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl optionally substituted with hydroxy, halogen or a heterocyclic group, carboxy, esterified carboxy, carbamoyl optionally substituted with heterocyclic(lower)alkyl or lower alkylamino(lower)alkyl, N-containing heterocycliccarbonyl optionally substituted with lower alkyl, or ureido optionally substituted with lower alkylamino(lower)alkyl, andR.sup.3 is hydrogen or halogen;R.sup.2 is phenyl substituted with nitro, andX is .dbd.N--or ##STR2## in which R.sup.4 is lower alkyl or halo(lower)alkyl, or is taken together with R.sup.1 to form an N-containing heterocyclic group optionally substituted with oxo and lower alkylamino(lower)alkyl; orR.sup.2 is lower alkyl, andX is ##STR3## in which R.sup.4 is phenyl substituted with nitro; and a pharmaceutically acceptable salt thereof, processes for the preparation thereof and pharmaceutical (e.g. antihypertension) compositions comprising the same.

    摘要翻译： 含有下式的杂环化合物：其中R 1为任选被羟基，卤素或杂环基取代的低级烷基，羧基，酯化羧基，任选被杂环（低级）烷基或低级烷基氨基（低级）烷基取代的氨基甲酰基 ，任选被低级烷基取代的含N杂环羰基或任选被低级烷基氨基（低级）烷基取代的脲基，R 3为氢或卤素; R 2为被硝基取代的苯基，X为= N-或其中R 4为低级烷基或卤代（低级）烷基），或与R 1一起形成任选被氧代取代的含氮杂环基 烷基氨基（低级）烷基; 或R2是低级烷基，X是其中R4是被硝基取代的苯基; 和其药学上可接受的盐，其制备方法和包含其的药物（例如抗高血压）组合物。

    Cephem compounds and processes for preparation thereof
    44.
    发明授权
    Cephem compounds and processes for preparation thereof 失效
    头孢烯化合物及其制备方法

    公开(公告)号：US4698337A

    公开(公告)日：1987-10-06

    申请号：US912212

    申请日：1986-09-25

    申请人： Takao Takaya ,  Hisashi Takasugi ,  Kiyoshi Tsuji ,  Toshiyuki Chiba

    发明人： Takao Takaya ,  Hisashi Takasugi ,  Kiyoshi Tsuji ,  Toshiyuki Chiba

    IPC分类号： C07D277/20 ,  C07D501/20 ,  C07D501/36 ,  A61K31/545

    CPC分类号： C07D277/587

    摘要： The invention relates to novel cephem compounds, of high antimicrobial activity, of the formula ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is lower alkyl substituted with 1 to 3 halogen atoms,R.sup.3 is thiadiazolylthiomethyl which may be substituted with lower alkyl, or tetrazolylthiomethyl which may be substituted with lower alkyl or lower alkenyl, andR.sup.4 is carboxy or protected carboxy, and a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及具有高抗微生物活性的新颖的头孢烯化合物，其具有下式：其中R 1为氨基或被保护的氨基，R 2为被1至3个卤素原子取代的低级烷基，R 3为可被低级烷基取代的噻二唑基硫甲基， 或可以被低级烷基或低级链烯基取代的四唑基硫甲基，R4是羧基或被保护的羧基，及其药学上可接受的盐。