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1.发明授权7-amino-3-[substituted vinyl]-3-cephem-4-carboxylates having antimicrobial activity 失效具有抗菌活性的7-氨基-3- [取代的乙烯基] -3-头孢烯-4-羧酸酯
公开(公告)号：US4639448A
公开(公告)日：1987-01-27
申请号：US741267
申请日：1985-06-04
IPC分类号： A61K20060101 , A61K31/54 , A61K31/545 , C07D20060101 , C07D501/00 , C07D501/04 , C07D501/14 , C07D501/18 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/48
CPC分类号： C07D501/24 , C07D501/18
摘要： The invention relates to cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or acylamino,R.sup.2 is lower alkyl, andY is CH or N.
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2.发明授权7-Substituted-3-vinyl-3-cephem compounds and processes for production of the same 失效7-取代的3-乙烯基-3-头孢烯化合物及其制备方法
公开(公告)号：US4559334A
公开(公告)日：1985-12-17
申请号：US543880
申请日：1983-10-20
IPC分类号： A61K31/545 , C07D20060101 , C07D501/22 , C07D501/24
CPC分类号： C07D501/22
摘要： The invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## in which R.sup.1 is amino or a protected amino group, andR.sup.2 is carboxy or a protected carboxy group, and a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及具有下式的高抗微生物活性的新化合物：其中R1是氨基或被保护的氨基，R2是羧基或被保护的羧基，及其药学上可接受的盐。
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3.发明授权New cephem compounds useful for treating infectious diseases in human being and animals and processes for preparation thereof 失效用于治疗人和动物中的感染性疾病的新头孢烯化合物及其制备方法
公开(公告)号：US4546101A
公开(公告)日：1985-10-08
申请号：US528796
申请日：1983-09-02
IPC分类号： A61K20060101 , A61K31/54 , A61K31/545 , C07D20060101 , C07D501/00 , C07D501/04 , C07D501/14 , C07D501/18 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/48
CPC分类号： C07D501/24 , C07D501/18
摘要： The invention relates to cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or acylamino,R.sup.2 is lower alkyl, andY is CH or N.
摘要翻译： 本发明涉及具有下式的高抗微生物活性的头孢烯化合物：其中R1是氨基或酰氨基，R2是低级烷基，Y是CH或N.
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公开(公告)号：US4515788A
公开(公告)日：1985-05-07
申请号：US402256
申请日：1982-07-27
申请人： Takao Takaya , Hisashi Takasugi , Hideaki Yamanaka
发明人： Takao Takaya , Hisashi Takasugi , Hideaki Yamanaka
IPC分类号： C07D501/06 , A61K31/546 , C07D277/20 , C07D277/30 , C07D501/20 , C07D501/22 , C07D501/34 , C07D501/36 , C07D501/59
CPC分类号： C07D277/587
摘要： This invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.2 is carboxy or protected carboxy,R.sup.3 is hydrogen or lower alkyl, andR.sup.4 is lower alkyl, lower alkoxy, acyloxymethyl, lower alkylthiomethyl, lower alkoxymethyl, halogen, lower alkenyl or hydrogen,and pharmaceutically acceptable salts thereof.
摘要翻译： 本发明涉及具有下式的高抗微生物活性的新化合物：其中R 1是羧基（低级）烷基或保护的羧基（低级）烷基，R 2是羧基或保护的羧基，R 3是氢或低级烷基，R 4是 低级烷基，低级烷氧基，酰氧基甲基，低级烷硫基甲基，低级烷氧基甲基，卤素，低级烯基或氢，及其药学上可接受的盐。
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5.发明授权
公开(公告)号：US4423213A
公开(公告)日：1983-12-27
申请号：US261618
申请日：1981-05-07
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D285/08 , C07D417/12 , C07D501/06 , C07D501/18 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/36 , C07F9/6561
CPC分类号： C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D277/587 , C07D285/08 , C07D417/12
摘要： The invention relates to novel 7-acylamino-3-vinylcephalosporanic acid derivatives of antimicrobial activity, and to methods of preparation thereof from novel intermediate compounds of the formula: ##STR1## in which R.sub.C is amino or a group of the formula: ##STR2## wherein R.sup.8 is aryl,A.sup.12 is lower alkylene having a group of the formula: .dbd.N.about.OR.sup.4, wherein R.sup.4 is hydrogen, cyclo(lower) alkenyl, lower alkynyl, lower alkenyl, lower alkenyl substituted by carboxy or a protected carboxy group, lower alkyl, or lower alkyl substituted by one or more substituent(s) selected from carboxy, a protected carboxy group, amino, a protected amino group, cyano, phosphono, a protected phosphono group and a heterocyclic group which may have suitable substituent(s),R.sup.a is a protected amino group,R.sup.b is a protected carboxy group,R.sup.c and R.sup.d are combined to form oxo or a protected oxo group, and X.sup.1 is halogen, andR.sup.2 is carboxy or a protected carboxy group, provided that, when R.sub.C is amino, then R.sup.2 is carboxy, or a salt thereof.
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公开(公告)号：US5110921A
公开(公告)日：1992-05-05
申请号：US583304
申请日：1990-09-17
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D285/08 , C07D417/12 , C07D501/06 , C07D501/18 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/36 , C07F9/6561
CPC分类号： C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D277/587 , C07D285/08 , C07D417/12
摘要： The invention relates to a compound of antibacterial activity of the formula: ##STR1## in which R.sup.1 is aminothiazolyl which may have halogen, aminothiadiazolyl, aminooxadiazolyl, aminopyridyl, aminopyrimidinyl, acyl aminothiazolyl which may have halogen, di(lower)alkylaminomethyleneaminothiadiazolyl, di(loweralkylaminomethyleneaminooxadiazolyl, or acylaminopyridyl,A is methylene which may have amino, a protected amino group, hydroxy or oxo, andR.sup.2 is carboxy or a protected carboxy group or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US4736039A
公开(公告)日：1988-04-05
申请号：US943057
申请日：1986-12-18
申请人： Takao Takaya , Hisashi Takasugi , Hideaki Yamanaka
发明人： Takao Takaya , Hisashi Takasugi , Hideaki Yamanaka
IPC分类号： C07D501/06 , A61K31/546 , C07D277/20 , C07D277/30 , C07D501/20 , C07D501/22 , C07D501/34 , C07D501/36 , C07D501/59
CPC分类号： C07D277/587
摘要： This invention relates to novel compounds of the formula: ##STR1## wherein R.sup.1 is carboxy(lower)alkyl or protected carboxy(lower)alkyl, andR.sup.6 is carboxy or protected carboxy, and a slat, thereof, and processes for preparing the same, useful in the preparation of compounds of high antimicrobial activity.
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公开(公告)号：US4649136A
公开(公告)日：1987-03-10
申请号：US690985
申请日：1985-01-14
申请人： Takao Takaya , Hisashi Takasugi , Hideaki Yamanaka
发明人： Takao Takaya , Hisashi Takasugi , Hideaki Yamanaka
IPC分类号： C07D501/06 , A61K31/546 , C07D277/20 , C07D277/30 , C07D501/20 , C07D501/22 , C07D501/34 , C07D501/36 , C07D501/59 , A61K31/545
CPC分类号： C07D277/587
摘要： This invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.2 is carboxy or protected carboxy,R.sup.3 is hydrogen or lower alkyl, andR.sup.4 is lower alkyl, lower alkoxy, acyloxymethyl, lower alkylthiomethyl, lower alkoxymethyl, halogen, lower alkenyl or hydrogen,and pharmaceutically acceptable salts thereof,and processes for making the same.
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9.发明授权7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof 失效7-酰氨基-3-取代头孢烷酸衍生物及其制备方法
公开(公告)号：US4409215A
公开(公告)日：1983-10-11
申请号：US206831
申请日：1980-11-14
IPC分类号： C07D501/32 , A61K31/545 , A61K31/546 , A61P31/04 , C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D285/08 , C07D417/12 , C07D501/18 , C07D501/22 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/20
CPC分类号： C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D277/587 , C07D285/08 , C07D417/12
摘要： The invention relates to novel 7-acylamino-3-substituted cephalosporanic acid derivatives of high antimicrobial activity, of the formula ##STR1## in which R.sup.5 is amino or a protected amino group,R.sup.2 is methoxymethyl,R.sup.3 is carboxy or a protected carboxy group, andR.sup.6 is lower alkyl, and a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及高抗微生物活性的新颖的7-酰基氨基-3-取代的头孢菌酸衍生物，其中R5是氨基或被保护的氨基，R2是甲氧基甲基，R3是羧基或被保护的羧基， 和R6是低级烷基，及其药学上可接受的盐。
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10.发明授权7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof 失效7-酰基氨基-3-乙烯基头孢烷酸衍生物及其制备方法
公开(公告)号：US4409214A
公开(公告)日：1983-10-11
申请号：US205334
申请日：1980-11-10
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D285/08 , C07D417/12 , C07D501/06 , C07D501/18 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/36 , C07F9/6561 , C07D501/34
CPC分类号： C07D209/48 , C07D213/75 , C07D239/42 , C07D257/06 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/46 , C07D277/48 , C07D277/56 , C07D277/587 , C07D285/08 , C07D417/12
摘要： This invention relates to novel 7-acylamino-3-vinyl-cephalosporanic acid derivatives and pharmaceutically acceptable salts thereof, of high antimicrobial activity.
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