公开(公告)号：US20180071405A1

公开(公告)日：2018-03-15

申请号：US15807844

申请日：2017-11-09

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Dong Wook KIM ,  Jin Soo KIM ,  Chul Yong PARK ,  Duk Hyoung KIM ,  Jung Eun KIM ,  Jiyeon KWEON

IPC: A61K48/00 ,  C12N5/074 ,  C12N9/22 ,  C12N15/11 ,  A61K35/545

CPC classification number: A61K48/005 ,  A61K35/12 ,  A61K35/545 ,  A61K48/00 ,  C07K14/755 ,  C12N5/0696 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113 ,  C12N2310/20 ,  C12N2501/73 ,  C12N2506/09

Abstract: The present invention provides a method for inducing an inversion of normal blood coagulation factor VIII (F8) gene, a method for correcting an inversion of blood coagulation factor VIII gene in which the inversion has occurred, and a Hemophilia A patient-derived induced pluripotent stem cell in which the inversion is corrected, constructed using the same. The method of the present invention effectively reproduces the inversion of intron 1 and intron 22 of the F8 gene, which is responsible for the majority of severe hemophilia A, and thereby may be effectively used for studying the development mechanism of hemophilia A and as a research tool for screening therapeutic agents. The inversion-corrected induced pluripotent stem cell constructed according the method of the present invention enables an efficient and fundamental treatment for hemophilia A by restoring a genotype in which mutation has occurred to a wild type-like state, without limitation via normal gene or protein delivery.

公开(公告)号：US20180000802A1

公开(公告)日：2018-01-04

申请号：US15703804

申请日：2017-09-13

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-Joon KIM ,  Su-Yeon CHOI ,  Wook-Suk CHUNG ,  Eun-Ee LEE ,  Ha-Ram PARK

IPC: A61K31/44 ,  A61K31/13 ,  A61K31/439 ,  A61K31/662

CPC classification number: A61K31/44 ,  A61K31/13 ,  A61K31/439 ,  A61K31/662

Abstract: The present invention relates to a pharmaceutical composition for improving a sociability behavior in a patient having a mental disease with an enhanced NMDAR function.

公开(公告)号：US20170320045A1

公开(公告)日：2017-11-09

申请号：US15586068

申请日：2017-05-03

Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Kimoon KIM ,  Gyeongwon YUN ,  Zahid HASSAN ,  Jiyeong LEE ,  Jeehong KIM ,  Nam Hoon KIM ,  Kangkyun BAEK ,  Ilha HWANG

IPC: B01J23/52 ,  C08J7/12 ,  C08J7/06 ,  B01J23/44 ,  B01J23/42 ,  B01J35/02 ,  B01J35/00 ,  B01J37/02

CPC classification number: B01J23/52 ,  B01J13/14 ,  B01J13/18 ,  B01J13/20 ,  B01J23/42 ,  B01J23/44 ,  B01J31/06 ,  B01J33/00 ,  B01J35/002 ,  B01J35/0033 ,  B01J35/0086 ,  B01J35/02 ,  B01J35/023 ,  B01J37/0201 ,  B01J37/16 ,  B82Y30/00 ,  C08J7/06 ,  C08J7/12 ,  C08J2381/02

Abstract: Provided are a polymer capsule loaded with transition metal particles having excellent water dispersibility and stability, and a method for preparing the same. Specifically, the polymer capsule loaded with transition metal particles according to the present invention includes a surface-modified polymer capsule surface-modified to thereby have a positive zeta potential in a dispersed state in water; and transition metal particles loaded on a surface of the surface-modified polymer capsule. In addition, a method for preparing a polymer capsule loaded with transition metal particles according to the present invention includes a) preparing a polymer capsule; b) surface-modifying the polymer capsule to prepare a polymer capsule having a positive zeta potential in a dispersed state in water; and c) sequentially adding a water-soluble transition metal precursor and a reducing agent to a water dispersion of the surface-modified polymer capsule obtained in step b).

公开(公告)号：US20170274098A1

公开(公告)日：2017-09-28

申请号：US15337252

申请日：2016-10-28

Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Won Jong KIM ,  Jinhwan KIM

IPC: A61K48/00 ,  C08G73/02

CPC classification number: A61K48/0041 ,  C08B37/003 ,  C08G69/10 ,  C08G73/0206

Abstract: Provided is a gene delivery including a polymer network formed by binding phenylboronic acid, sugar, and a low-molecular weight branched polymer. The gene delivery may be stably maintained in vivo and efficiently deliver a gene specifically to cancer cells, such that the gene delivery system may be usefully used as a gene delivery system for chemotherapy.

公开(公告)号：US20170240572A1

公开(公告)日：2017-08-24

申请号：US14891096

申请日：2015-01-29

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sukbok Chang ,  Sehoon Park ,  Narasimhulu Gandhamsetty ,  Seewon Joung ,  Sung-Woo Park

IPC: C07F7/08

CPC classification number: C07F7/0896 ,  B01J31/14 ,  C07F7/0829 ,  C07F7/0836 ,  C07F7/0874

Abstract: Provided is a method of preparing a silylative-reduced N-heterocyclic compound by reducing an N-heteroaromatic compound including a sp2 hybridized nitrogen atom while simultaneously introducing a silyl group into a beta-position with respect to a nitrogen atom of the N-heteroaromatic compound, using a silane compound, in the presence of an organoboron catalyst.

公开(公告)号：US20170076039A1

公开(公告)日：2017-03-16

申请号：US15306270

申请日：2015-04-24

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin Soo Kim ,  Sang Su Bae

IPC: G06F19/24 ,  G06F19/18

CPC classification number: G16B40/00 ,  G16B20/00

Abstract: The present invention relates to a method of selecting a nuclease target sequence for gene knockout based on microhomology.

Abstract translation: 本发明涉及一种基于微生物学选择基因敲除的核酸酶靶序列的方法。

公开(公告)号：US20170052131A1

公开(公告)日：2017-02-23

申请号：US14947538

申请日：2015-11-20

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyunwoo KIM ,  Min-Seob SEO

IPC: G01N24/08 ,  C07C215/56

CPC classification number: G01N24/08 ,  C07B2200/07 ,  C07C215/50 ,  C07C2601/14 ,  C07F5/003 ,  C07F5/069 ,  C07F7/28

Abstract: Provided are novel ligand, a chiral metal complex including the same, and a use of the chiral metal complex for analyzing the chirality of a charged compound by 1H NMR spectroscopy. The chiral metal complex of the present invention may be used as the chiral solvating agent to conveniently analyze the optical purity of charged compounds such as various amine derivatives, carboxylic acid derivatives, cyanohydrin derivatives and charged metal complexes by 1H NMR spectroscopy.

Abstract translation: 提供了新型配体，包括其的手性金属络合物，以及手性金属络合物用于通过1 H NMR光谱分析带电荷化合物的手性的用途。 本发明的手性金属络合物可以用作手性溶剂化剂，以便通过1 H NMR光谱方便地分析带电荷化合物如各种胺衍生物，羧酸衍生物，羟腈衍生物和带电金属配合物的光学纯度。

公开(公告)号：US20160120858A1

公开(公告)日：2016-05-05

申请号：US14932812

申请日：2015-11-04

Applicant: ACADEMIA SINICA ,  INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  THE ASAN FOUNDATION

Inventor： Eun-Joon KIM ,  Eun-Jae LEE ,  Hye-Jin LEE ,  Yi-Ping HSUEH ,  Tzyy-Nan Huang ,  Jae-Young KOH

IPC: A61K31/47 ,  A61K9/00

CPC classification number: A61K31/47 ,  A61K9/0019

Abstract: The present invention relates to a pharmaceutical composition for treating autism spectrum disorders, which includes clioquinol or pharmaceutically acceptable salt thereof. In addition, the present invention relates to a food composition for treating autism spectrum disorders, which includes clioquinol or pharmaceutically acceptable salt thereof.

Abstract translation: 本发明涉及用于治疗孤独症谱系障碍的药物组合物，其包括氯碘喹啉或其药学上可接受的盐。 此外，本发明涉及用于治疗自闭症谱系障碍的食品组合物，其包括氯碘喹啉或其药学上可接受的盐。

公开(公告)号：US20160089436A1

公开(公告)日：2016-03-31

申请号：US14670890

申请日：2015-03-27

Applicant: SNU R&DB FOUNDATION ,  Institute for Basic Science ,  The Catholic University of Korea Industry-Academic Cooperation Foundation

Inventor： Taeghwan Hyeon ,  Kun Na ,  Daishun Ling ,  Wooram Park

IPC: A61K41/00 ,  A61K49/12

CPC classification number: A61K41/0071 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/1857

Abstract: The present invention relates to a nanoformulated self-assembled pharmaceutical composition for photodynamic therapy. More particularly, the present invention is directed to a self-assembled pharmaceutical composition for photodynamic therapy comprising a photosensitizer, a ligand A which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range and a method for manufacturing the same.

Abstract translation: 本发明涉及用于光动力疗法的纳米结构的自组装药物组合物。 更具体地，本发明涉及一种用于光动力疗法的自组装药物组合物，其包含光敏剂，在特定pH范围分离的配体A和在特定pH范围内表面电荷变化的配体B和 制造方法

公开(公告)号：US20150164468A1

公开(公告)日：2015-06-18

申请号：US14538039

申请日：2014-11-11

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： CHI YOUNG AHN ,  KI WAN JEON ,  SUNG HO KANG

IPC: A61B8/08 ,  G06T17/00 ,  A61B8/06

CPC classification number: A61B8/0883 ,  A61B8/06 ,  A61B8/488 ,  A61B8/5207 ,  A61B8/5223 ,  A61B8/5253 ,  G01S15/8984 ,  G01S15/8993 ,  G01S15/8995 ,  G06T7/269 ,  G06T7/55 ,  G06T17/00 ,  G06T2207/10132 ,  G06T2207/30048 ,  G06T2207/30104

Abstract: An apparatus and method for processing an echocardiogram using the Navier-Stokes equation is provided. The apparatus includes an ultrasonic sensor that transmits ultrasonic waves to the heart in three different directions and receives echoes thereof; an image processor that constructs first to third echocardiograms captured from the three different directions, respectively, based on the received echoes of the ultrasonic waves; a three-dimensional model construction unit that constructs a three-dimensional model of a left ventricle of the heart based on the first to third echocardiograms; and a blood flow vector calculation unit that calculates blood flow vectors within the left ventricle by applying the three-dimensional model of the left ventricle to boundary conditions in the Navier-Stokes equation. In echocardiogram processing, vector components of the blood flow within the left ventricle are calculated using the Navier-Stokes equation, whereby the vector components of the blood flow can be more accurately calculated.

Abstract translation: 提供了一种使用Navier-Stokes方程处理超声心动图的装置和方法。 该装置包括：超声波传感器，其以三个不同的方向向心脏发送超声波并接收其回波; 基于所接收到的超声波的回波，分别构建从三个不同方向捕获的第一到第三超声心动图的图像处理器; 基于第一至第三超声心动图构建心脏左心室的三维模型的三维模型构建单元; 以及血流矢量计算单元，其通过将所述左心室的三维模型应用于Navier-Stokes方程中的边界条件来计算所述左心室内的血流矢量。 在超声心动图处理中，使用Navier-Stokes方程计算左心室内血流量的矢量分量，从而可以更精确地计算血流的矢量分量。