公开(公告)号：US20170196850A1

公开(公告)日：2017-07-13

申请号：US15415188

申请日：2017-01-25

Applicant: Consejo Superior de Investigaciones Cientificas (CSIC)

Inventor： Ana Martinez Gil ,  Carmen Gil Ayuso-Gontan ,  Valle Palomo Ruiz ,  Concepcion Perez Martin ,  Daniel I. Perez Fernandez ,  Julio Alberto Reyes Rodriguez

IPC: A61K31/4704

CPC classification number: A61K31/4704 ,  A61K45/06 ,  C07D215/56

Abstract: The present invention relates to heterocyclic substituted quinoline derivatives as allosteric inhibitors of the glycogen synthase kinase-3 (GSK-3) enzyme. Therefore, these compounds are useful for the manufacturing of a medicament designed for the treatment and/or prevention of diseases wherein GSK-3 is involved, such as neurodegenerative diseases, inflammatory diseases, cancer, diabetes, and to promote various regenerative processes.

公开(公告)号：US20170138804A1

公开(公告)日：2017-05-18

申请号：US15300510

申请日：2015-03-27

Applicant: INSTITUT FRANCAIS DES SCIENCES ET TECHNOLOGIES DES TRANSPORTS, DE L'AMÉNAGEMENT ET DES RÉSEAUX ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS ,  ECOLE POLYTECHNIQUE

Inventor： Berengere LEBENTAL ,  Boutheina GHADDAD ,  Vincent GAUDEFROY ,  Eduardo RUIZ-HITZKY ,  Pilar ARANDA GALLEGO ,  Cristina RUIZ GARCIA ,  Birger HENNINGS

IPC: G01L1/20 ,  G01G19/02

CPC classification number: G01L1/205 ,  G01G19/021

Abstract: An acquisition device (20) comprising a wall and a transducer (23) constituted by a body (24, 324) on which electrodes (25) are fastened spaced apart from one another.An electrical impedance (R) of the transducer is variable as a function of deformation of the transducer.When looking in a direction perpendicular to a surface (36) of the wall, at least two electrodes (25) of said plurality of electrodes are spaced apart from each other.The transducer is incorporated under the surface (36) of the wall.

公开(公告)号：US09585879B2

公开(公告)日：2017-03-07

申请号：US14920030

申请日：2015-10-22

Applicant: Consejo Superior de Investigaciones Cientificas (CSIC)

Inventor： Ana Martinez Gil ,  Carmen Gil Ayuso-Gontan ,  Valle Palomo Ruiz ,  Concepcion Perez Martin ,  Daniel I. Perez Fernandez ,  Julio Alberto Reyes Rodriguez

IPC: A61K31/4704 ,  A61K45/06 ,  C07D215/56

CPC classification number: A61K31/4704 ,  A61K45/06 ,  C07D215/56

Abstract: The present invention relates to heterocyclic substituted quinoline derivatives as allosteric inhibitors of the glycogen synthase kinase-3 (GSK-3) enzyme. Therefore, these compounds are useful for the manufacturing of a medicament designed for the treatment and/or prevention of diseases wherein GSK-3 is involved, such as neurodegenerative diseases, inflammatory diseases, cancer, diabetes, and to promote various regenerative processes.

Abstract translation: 本发明涉及作为糖原合成酶激酶-3（GSK-3）酶的变构抑制剂的杂环取代喹啉衍生物。 因此，这些化合物可用于制备用于治疗和/或预防涉及GSK-3的疾病，例如神经变性疾病，炎性疾病，癌症，糖尿病，并促进各种再生过程的药物。

公开(公告)号：US09501712B2

公开(公告)日：2016-11-22

申请号：US14398491

申请日：2013-05-03

Applicant: Universidad de Sevilla ,  Consejo Superior de Investigaciones Cientificas

Inventor： Jorge Fernandez Berni ,  Angel Rodrigez Vazquez ,  Ricardo Carmona Galan

IPC: G06K9/00 ,  G06K9/46 ,  H04N5/378 ,  G06T1/20 ,  G06T5/00 ,  G06T7/00 ,  G06K9/56

CPC classification number: G06K9/4604 ,  G06K9/00973 ,  G06K9/56 ,  G06T1/20 ,  G06T5/00 ,  G06T5/003 ,  G06T7/13 ,  G06T2200/28 ,  G06T2207/20024 ,  H04N5/378

Abstract: Device for edge detection and quality enhancement in an image which comprises a grouping of identical and locally interconnected elementary processing cells. Each processing cell is characterized in turn by a comparator which carries out in parallel the comparison of each pair of neighboring pixels. The threshold voltage which establishes the difference in voltage between pixels considered to be part of an edge is determined by means of a temporary adjustment of a control signal. This adjustment, along with that of the filtering control signal, also temporary in nature, are the only ones necessary for configuring the required processing. No external analog control signals are required making it easier to program the hardware by the device which is used and reducing the number of digital/analog converters of the final system.

Abstract translation: 用于边缘检测和图像质量增强的装置，其包括相同和局部互连的基本处理单元的分组。 每个处理单元依次由比较器进行表征，该比较器并行执行每对相邻像素的比较。 通过控制信号的临时调整来确定建立被认为是边缘的一部分的像素之间的电压差的阈值电压。 这种调整以及过滤控制信号的调整本质上也是临时的，是配置所需处理所需的唯一调整。 不需要外部模拟控制信号，使得更容易通过所使用的设备对硬件进行编程，并减少最终系统的数字/模拟转换器的数量。

公开(公告)号：US20160279180A1

公开(公告)日：2016-09-29

申请号：US14913514

申请日：2014-08-21

Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)

Inventor： Baltasar Mayo Pérez ,  Susana Delgado Palacio

IPC: A61K35/747 ,  A23C9/123 ,  C12R1/225

CPC classification number: A61K35/747 ,  A23C9/1234 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/71 ,  A61K35/741 ,  C12N1/20 ,  C12R1/225

Abstract: The invention relates to a new strain of Lactobacillus reuteri isolated from the human stomach, exhibiting antioxidant and antimicrobial activity, in particular an anti-Helicobacter effect, considerable resistance to the conditions of the gastric ecosystem, and the capacity to adhere to the epithelium. The invention also relates to a probiotic or biotherapeutic product which contains the strain of L. reuteri and is suitable for use in the treatment or prophylaxis of gastric diseases caused by the Helicobacter pylori bacteria, in order to prevent the secondary effects associated with conventional antibiotic treatments.

Abstract translation: 本发明涉及从人胃分离的新型罗伊氏乳杆菌菌株，具有抗氧化和抗微生物活性，特别是抗幽门螺杆菌作用，对胃生态系统的条件具有相当大的抗性，并且具有粘附于上皮的能力。 本发明还涉及包含罗伊氏乳杆菌菌株的益生菌或生物治疗产品，并且适用于治疗或预防由幽门螺杆菌引起的胃疾病，以防止与常规抗生素治疗相关的次要作用 。

公开(公告)号：US09416068B2

公开(公告)日：2016-08-16

申请号：US13714542

申请日：2012-12-14

Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) ,  UNIVERSIDAD POLITECNICA DE VALENCIA

Inventor： Avelino Corma Canos ,  Michael Renz ,  Olalla De La Torre Alfaro

IPC: C07C1/20 ,  C07C2/02 ,  C07C2/04 ,  C07C5/02 ,  C07C5/27 ,  C07C1/24 ,  C10G3/00 ,  C10G45/10 ,  C10G50/00 ,  C10G69/12 ,  C10G45/02 ,  B01J21/18 ,  B01J23/36 ,  B01J23/40 ,  B01J23/42 ,  B01J23/72 ,  B01J23/755 ,  B01J27/02

CPC classification number: C07C1/24 ,  B01J21/18 ,  B01J23/36 ,  B01J23/40 ,  B01J23/42 ,  B01J23/72 ,  B01J23/755 ,  B01J27/02 ,  C10G3/44 ,  C10G3/45 ,  C10G3/47 ,  C10G3/48 ,  C10G3/52 ,  C10G45/02 ,  C10G45/10 ,  C10G50/00 ,  C10G69/126 ,  C10G2300/1011 ,  C10G2300/1014 ,  C10G2400/04 ,  Y02P30/20

Abstract: The invention relates to a method for producing liquid fuel having a high alkane content and a low oxygenized compound content, said method comprising at least: a first step of treating 2-methylfuran with a catalyst and water in reaction conditions in order to form a mixture of products with at least ten carbon atoms; and a second step of catalytic hydrogenation and dehydration of the product or the mixture obtained in step 1, using suitable hydrogenation and dehydration catalysts.

Abstract translation: 本发明涉及一种生产具有高烷烃含量和低含氧化合物含量的液体燃料的方法，所述方法至少包括：在反应条件下用催化剂和水处理2-甲基呋喃以形成混合物的第一步骤 具有至少十个碳原子的产物; 以及使用合适的氢化和脱水催化剂催化氢化和脱水步骤1中获得的产物或混合物的第二步骤。

公开(公告)号：US20160128562A1

公开(公告)日：2016-05-12

申请号：US14900691

申请日：2014-07-02

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Inventor： Nicholas James Durr ,  Eduardo Lage Negro ,  Shivang R. Dave ,  Carlos Dorronsoro Diaz ,  Susana Marcos Celestino ,  Daryl Lim

IPC: A61B3/103 ,  A61B5/00 ,  A61B3/18 ,  A61B3/00 ,  A61B3/10

CPC classification number: A61B3/103 ,  A61B3/0025 ,  A61B3/0041 ,  A61B3/0091 ,  A61B3/1015 ,  A61B3/113 ,  A61B3/145 ,  A61B3/152 ,  A61B3/18 ,  A61B5/7415 ,  A61B5/7455 ,  A61B2560/0425 ,  A61F9/008

Abstract: Eye prescriptions may be determined by providing a simple, easy to use, portable device with a specially configured targeting light source that aligns the eye, mitigates accommodation, and provides accurate results. Unlike stationary, closed view autorefractors, this device typically is portable, self-usable, relatively inexpensive, enabling more widespread use across the world.

公开(公告)号：US20160102316A1

公开(公告)日：2016-04-14

申请号：US14894109

申请日：2014-05-29

Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS(CSIC)

Inventor： Vicente Rubio Munoz ,  Elisa Iniesto Sanchez ,  Maria Luisa Irigoyen Miguel

IPC: C12N15/82 ,  A01H1/06

CPC classification number: C12N15/8202 ,  A01H1/06 ,  A01H5/00 ,  C12N15/8261 ,  C12N15/8267 ,  C12N15/827 ,  C12N15/8273 ,  C12N15/8293 ,  Y02A40/146

Abstract: The invention relates to transgenic plants and methods for modulating abscisic acid (ABA) perception and signal transduction in plants. The plants fmd use in increasing yield in plants, particularly under abiotic stress.

Abstract translation: 本发明涉及用于调节植物中脱落酸（ABA）感知和信号转导的转基因植物和方法。 植物fmd用于增加植物的产量，特别是在非生物胁迫下。

公开(公告)号：US20150246851A1

公开(公告)日：2015-09-03

申请号：US14429546

申请日：2013-09-19

Applicant: THE PENN STATE RESEARCH FOUNDATION ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)

Inventor： Pilar Miranzo ,  Carmen Ocal ,  Maria Isabel Osendi ,  Manuel Belmonte ,  Cristina Ramirez ,  Benito Roman-Manso ,  Humberto R. Gutierrez ,  Mauricio Terrones

IPC: C04B35/573 ,  C04B35/64 ,  H01B1/18

CPC classification number: C04B35/573 ,  B82Y30/00 ,  C04B35/575 ,  C04B35/6261 ,  C04B35/64 ,  C04B35/645 ,  C04B2235/3217 ,  C04B2235/3224 ,  C04B2235/3225 ,  C04B2235/3227 ,  C04B2235/3418 ,  C04B2235/383 ,  C04B2235/3834 ,  C04B2235/422 ,  C04B2235/425 ,  C04B2235/443 ,  C04B2235/5436 ,  C04B2235/5454 ,  C04B2235/6567 ,  C04B2235/6581 ,  C04B2235/666 ,  C04B2235/78 ,  H01B1/04 ,  H01B1/18

Abstract: We provide a method for the in situ development of graphene containing silicon carbide (SiC) matrix ceramic composites, and more particularly to the in situ graphene growth within the bulk ceramic through a single-step approach during SiC ceramics densification using an electric current activated/assisted sintering (ECAS) technique. This approach allows processing dense, robust, highly electrical conducting and well dispersed nanocomposites having a percolated graphene network, eliminating the handling of potentially hazardous nanostructures. Graphene/SiC components could be used in technological applications under strong demanding conditions where good electrical, thermal, mechanical and/or tribological properties are required, such as micro and nanoelectromechanical systems (MEMS and NEMS), sensors, actuators, heat exchangers, breaks, components for engines, armours, cutting tools, microturbines or microrotors.

Abstract translation: 我们提供了一种用于原位开发包含碳化硅（SiC）基质陶瓷复合材料的石墨烯的方法，更具体地说，涉及在SiC陶瓷致密化期间通过单步法在体陶瓷内的原位石墨烯生长中使用电流激活/ 辅助烧结（ECAS）技术。 这种方法可以处理具有渗透石墨烯网络的致密，坚固，高导电性和良好分散的纳米复合材料，从而消除潜在危险的纳米结构的处理。 石墨烯/ SiC组分可用于需要良好的电，热，机械和/或摩擦学性能的强要求条件下的技术应用，如微和纳机电系统（MEMS和NEMS），传感器，致动器，换热器，断路器， 发动机，铠装，切削工具，微型涡轮机或微型电动机组件。

公开(公告)号：US20150172790A1

公开(公告)日：2015-06-18

申请号：US14417291

申请日：2013-07-12

Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)

Inventor： Manuel Delgado Restituto ,  Jose Antonio Rodriguez Rodriguez ,  Jesus Ruiz Amaya ,  Jens Masuch ,  Alberto Rodriguez Perez

IPC: H04Q9/00

CPC classification number: H04Q9/00 ,  A61B5/0024 ,  G01S13/758 ,  H04B5/0043 ,  H04B5/0062 ,  H04B5/0068 ,  H04Q2209/40 ,  H04Q2209/88 ,  H04W4/80

Abstract: A wireless telemetry system is proposed based on transmission of time reference for the monitoring of static and dynamic magnitudes. The proposed system comprises a reading instrument and, at least, a transponder which, in turn, includes the transducers associated to the variables object of observation and/or measurement. With the object of communicating the reading instrument and the transponder to each other, the system also comprises a mechanism for the transmission of information regarding the internal operating frequency of the transponder towards the reading instrument and a method for the remote determination of the internal operating frequency of the transponder. The reading instrument comprises: an antenna (11000), a communication section (12000), a signal processing section (13000), a computation section (14000), a timing unit (15000) stable with temperature, a user interface section (16000) and a data output section (17000).

Abstract translation: 提出了一种基于时间参考传输的无线遥测系统，用于监测静态和动态幅度。 所提出的系统包括读取仪器和至少一个应答器，该应答器又包括与观测和/或测量的变量对象相关联的换能器。 为了使读取仪器和应答器彼此通信，该系统还包括用于将关于应答器的内部工作频率的信息传送给读取仪器的机构，以及用于远程确定内部操作频率的方法 的转发器。 读取装置包括：天线（11000），通信部（12000），信号处理部（13000），计算部（14000），温度稳定的定时单元（15000），用户接口部（16000） 和数据输出部（17000）。