公开(公告)号：US20180222840A1

公开(公告)日：2018-08-09

申请号：US15946204

申请日：2018-04-05

Applicant: BRACCO IMAGING S.P.A.

Inventor： Roberta FRETTA ,  Pietro DELOGU ,  Fernanda DI GIORGIO ,  Alfonso NARDELLI ,  Stefano SGUASSERO ,  Carlo Felice VISCARDI

IPC: C07C67/08 ,  C07C51/44 ,  C07C67/287 ,  C07C67/54 ,  B01D3/00

CPC classification number: C07C67/08 ,  B01D3/009 ,  C07B2200/07 ,  C07C51/44 ,  C07C67/287 ,  C07C67/54 ,  C07C69/63 ,  C07C69/14 ,  C07C53/08 ,  C07C59/08

Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid.The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.

公开(公告)号：US20170340755A1

公开(公告)日：2017-11-30

申请号：US15535937

申请日：2015-12-18

Applicant: BRACCO IMAGING S.P.A.

Inventor： Alessandro MAIOCCHI ,  Chiara BRIOSCHI ,  Fulvio UGGERI ,  Giovanni VALBUSA

IPC: A61K49/00 ,  A61B10/00 ,  A61B5/08 ,  A61B5/00

Abstract: The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence- guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.

公开(公告)号：US09259491B2

公开(公告)日：2016-02-16

申请号：US14384414

申请日：2013-03-13

Applicant: BRACCO IMAGING S.P.A.

Inventor： Lorena Beltrami ,  Luciano Lattuada ,  Alessandro Maiocchi ,  Massimo Visigalli ,  Loredana Sini

IPC: C07D243/08 ,  C07F9/645 ,  A61K49/10

CPC classification number: A61K49/106 ,  C07D243/08 ,  C07F9/645

Abstract: The present invention relates to a new class of diazepine-derivatives as chelating agents for paramagnetic metal ions, the process for their preparation, and use of such paramagnetic complexes as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis. The present invention refers to a new class of derivatives of formula (I), or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明涉及一类新的二氮杂衍生物作为顺磁性金属离子的螯合剂，其制备方法以及使用这种顺磁络合物作为造影剂，特别适用于磁共振成像（MRI）分析。 本发明涉及一类新的式（I）衍生物或其药学上可接受的盐。

公开(公告)号：US09228221B2

公开(公告)日：2016-01-05

申请号：US14308468

申请日：2014-06-18

Applicant: Bracco Imaging S.p.A

Inventor： Robert C. Williams, Jr. ,  Patrice Marchildon

IPC: C12Q1/18 ,  C12Q1/22 ,  G01N31/22 ,  G01N33/50 ,  A61M5/00 ,  A61M5/14 ,  A61M5/142 ,  A61L2/28 ,  A61L2/18 ,  G01N13/00

CPC classification number: G01M3/2853 ,  A61L2/18 ,  A61L2/28 ,  A61M5/00 ,  A61M5/1408 ,  A61M5/1413 ,  A61M5/14232 ,  C12Q1/18 ,  C12Q1/22 ,  G01N31/226 ,  G01N33/50 ,  G01N2013/003 ,  Y10T436/13

Abstract: A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure.

Abstract translation: 流体输送系统可以包括容纳医疗流体的容器，流体加压单元和将医用流体从容器传送到流体加压单元的流体输送装置。 为了验证流体输送系统的完整性和无菌性，系统可以经历测试方案以评估系统对患者流体递送过程中的致病性进入，化学降解和/或流体交叉污染的易感性。 测试方案可能有助于确保在多个不同流体输送过程中使用的输送系统组件以及在每个流体输送程序之后更换组件。

公开(公告)号：US20150037261A1

公开(公告)日：2015-02-05

申请号：US14384414

申请日：2013-03-13

Applicant: BRACCO IMAGING S.P.A

Inventor： Lorena Beltrami ,  Luciano Lattuada ,  Alessandro Maiocchi ,  Massimo Visigalli ,  Loredana Sini

IPC: A61K49/10 ,  C07F9/645 ,  C07D243/08

CPC classification number: A61K49/106 ,  C07D243/08 ,  C07F9/645

Abstract: The present invention relates to a new class of diazepine-derivatives as chelating agents for paramagnetic metal ions, the process for their preparation, and use of such paramagnetic complexes as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

Abstract translation: 本发明涉及一类新的二氮杂衍生物作为顺磁性金属离子的螯合剂，其制备方法以及使用这种顺磁络合物作为造影剂，特别适用于磁共振成像（MRI）分析。

公开(公告)号：US12187708B2

公开(公告)日：2025-01-07

申请号：US18388604

申请日：2023-11-10

Applicant: BRACCO IMAGING S.P.A.

Inventor： Francesco Blasi ,  Federica Buonsanti ,  Federico Crivellin ,  Andrea Ferraris ,  Laura Orio ,  Lorena Pizzuto ,  Roberta Napolitano ,  Giovanni Valbusa

IPC: C07D403/10 ,  C07D403/14 ,  C09B23/01

Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

公开(公告)号：US20240273362A1

公开(公告)日：2024-08-15

申请号：US18568454

申请日：2022-10-14

Applicant: BRACCO IMAGING S.P.A.

Inventor： Giovanni Valbusa ,  Sonia Colombo Serra ,  Alberto Fringuello Mingo ,  Fabio Tedoldi ,  Davide Bella

IPC: G06N3/08 ,  G06N20/00 ,  G06T7/00 ,  G16H30/00

CPC classification number: G06N3/08 ,  G06N20/00 ,  G06T7/0012 ,  G16H30/00 ,  G06T2207/20081 ,  G06T2207/20084

Abstract: A solution is proposed for training a machine learning model (420) for use in medical imaging applications. A corresponding method (700) comprises providing (703-743: 759-763) sample sets, each comprising a sample baseline image, a sample target image (acquired from a corresponding body-part of a subject to which a contrast agent at a certain dose has been administered) and a sample source dose (corresponding to a different dose of the contrast agent). The machine learning model (420) is trained (744-758) so as to optimize its capability of generating each sample target image from the corresponding sample baseline image and sample source image. One or more of the sample sets are incomplete, missing their sample source images. Each incomplete sample set is completed (704-742: 759-763) by simulating the sample source image from at least the sample baseline image and the sample target image of the sample set. A computer programs (500) and a computer program products for implementing the method (700) are proposed. Moreover, a computing system (130) for performing the method (700) is proposed.

公开(公告)号：US20230040042A1

公开(公告)日：2023-02-09

申请号：US17784232

申请日：2020-12-09

Applicant: BRACCO IMAGING S.P.A.

Inventor： Aurelia FERRIGATO ,  Sonia GAZZETTO

IPC: C07D257/02

Abstract: The invention relates to a process for the one-step preparation and isolation of a protected DO3A such as DO3A-tri-tert-butyl ester as a solid salt.

公开(公告)号：US20220242853A1

公开(公告)日：2022-08-04

申请号：US17610779

申请日：2020-05-12

Applicant: BRACCO IMAGING S.P.A.

Inventor： Francesco BLASI ,  Chiara BRIOSCHI ,  Federica BUONSANTI ,  Luigi MIRAGOLI ,  Roberta NAPOLITANO ,  Laura ORIO ,  Lorena PIZZUTO ,  Giovanni VALBUSA

IPC: C07D403/14 ,  C07D403/06 ,  C07D471/04 ,  C09B23/06 ,  C09B23/08 ,  A61K49/00

Abstract: The present invention relates to the field of optical imaging More particularly, it relates to compounds of the cyanine family characterized by improved physico-chemical and biological properties and to their conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

公开(公告)号：US20210292762A1

公开(公告)日：2021-09-23

申请号：US17262835

申请日：2019-07-24

Applicant: BRACCO IMAGING S.P.A.

Inventor： Vittorio DE FRANCISCIS ,  Silvia CATUOGNO ,  Carla Lucia ESPOSITO ,  Alessandro MAIOCCHI ,  Margherita IABONI ,  Luisa POGGI ,  Erika REITANO

IPC: C12N15/115

Abstract: The present invention provides nucleic acid aptamers binding to the Intercellular Adhesion Molecule-1 (ICAM-1), derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing ICAM-1, or as therapeutic agents for prevention or treatment of ICAM-1-related diseases.