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    ASYNCHRONOUS CLOCK SIGNAL GENERATOR AND SEMICONDUCTOR DEVICE FOR CORRECTING MULTI-PHASE SIGNALS USING ASYNCHRONOUS CLOCK SIGNAL
    453.
    发明申请
    ASYNCHRONOUS CLOCK SIGNAL GENERATOR AND SEMICONDUCTOR DEVICE FOR CORRECTING MULTI-PHASE SIGNALS USING ASYNCHRONOUS CLOCK SIGNAL 审中-公开

    公开(公告)号：US20190181846A1

    公开(公告)日：2019-06-13

    申请号：US16279719

    申请日：2019-02-19

    Applicant: SK hynix Inc. ,  Korea Advanced Institute of Science and Technology

    Inventor： Seonggyu LEE ,  Yongjo KIM ,  SeongHwan CHO

    IPC: H03K5/15

    CPC classification number: H03K5/15033 ,  H03K2005/00058

    Abstract: A semiconductor device includes a delay circuit configured to adjust a delay amount of multi-phase input signals to output multi-phase signals; a clock generator configured to output a clock signal that is not synchronized with an input signal which corresponds to one of the multi-phase signals; a detector circuit configured to generate a pulse signal corresponding to a phase difference between a reference signal corresponding to a predetermined one of the multi-phase signals and a comparison signal corresponding to a selected one of the multi-phase signals and to sample the pulse signal according to the clock signal; and a controller circuit configured to output a delay control signal for controlling a delay amount of the multi-phase input signals or controlling a delay amount of the comparison signal according to a result of calculating an output of the detector circuit and a reference value corresponding to the phase difference.

    Magnetic resonance imaging apparatus and control method
    457.
    发明授权
    Magnetic resonance imaging apparatus and control method 有权

    公开(公告)号：US10295643B2

    公开(公告)日：2019-05-21

    申请号：US14804678

    申请日：2015-07-21

    Applicant: SAMSUNG ELECTRONICS CO., LTD. ,  Korea Advanced Institute of Science and Technology

    Inventor： Hyun Wook Park ,  Yong Wan Lim ,  Ye Ji Han

    IPC: G01R33/567 ,  G01R33/48

    Abstract: A magnetic resonance imaging (MRI) apparatus and a control method thereof are provided. The MRI apparatus includes a scanner, and a controller configured to control the scanner to receive magnetic resonance (MR) signals corresponding to a magnitude of a y-axis gradient magnetic field in a respiration cycle of a patient, each of the MR signals being received at a time interval equal to a time period of the respiration cycle over a number of the received MR signals. The MRI apparatus further includes a processor configured to extract an MR signal received in a respiration condition of the patient from the received MR signals, fill a k-space with the extracted MR signal, and generate an MR image by reconstructing data of the filled k-space.

    Induced pluripotent stem cell model for Fabry disease and use thereof
    458.
    发明授权
    Induced pluripotent stem cell model for Fabry disease and use thereof 有权

    公开(公告)号：US10287554B2

    公开(公告)日：2019-05-14

    申请号：US14839603

    申请日：2015-08-28

    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

    Inventor： Yong-mahn Han ,  Sang-Wook Park

    IPC: C12N5/074 ,  G01N33/50

    Abstract: The present invention relates to an induced pluripotent stem cell model of Fabry disease, a preparation method thereof, and a use of the same for the study of Fabry disease development and for the screening of a therapeutic agent for the disease. Particularly, Fabry disease derived induced pluripotent stem cells (iPSCs), embryoid body (EB), and vascular cells were developed and differentiated from fibroblasts originated from Fabry disease patient, wherein the Fabry disease originated iPSCs displayed significantly reduced expression and activity of GLA protein therein, compared with the normal cells, resulting in the accumulation of globotriaosylceramide (Gb3, CD77). Also, the differentiation of vascular cells was induced from the Fabry disease originated iPSCs, and as a result the iPSCs were successfully differentiated into vascular endothelial cells and vascular smooth muscle cells with significantly expressing the marker protein. When the vascular endothelial cells and vascular smooth muscle cells were treated with Fabrazyme, the accumulation of Gb3 was significantly reduced, suggesting that the said cell model can be effectively used for the analysis/study of Fabry disease outbreak mechanism and for the screening of a therapeutic agent for the disease.

    Polypeptide for binding to complement protein C5A, and use of same
    459.
    发明授权
    Polypeptide for binding to complement protein C5A, and use of same 有权

    公开(公告)号：US10287342B2

    公开(公告)日：2019-05-14

    申请号：US15500921

    申请日：2015-08-03

    Applicant: Korea Advanced Institute of Science and Technology

    Inventor： Hak-Sung Kim ,  Da Eun Hwang ,  Jung-Min Choi ,  Joong-Jae Lee ,  Woosung Heu

    IPC: A61K39/00 ,  A61K39/02 ,  C07H21/04 ,  C07K16/18 ,  C12N15/62 ,  C07K14/725 ,  C07K14/34 ,  A61K38/00

    Abstract: The present invention relates to novel polypeptide for binding to a complement protein C5a. More particularly, the present invention relates to polypeptide which can be bound to a complement protein C5a and inhibit the activation of same, polynucleotide which codes for the polypeptide, a recombinant vector which comprises the polynucleotide, a recombinant microorganism to which the recombinant vector has been introduced, a method for producing the polypeptide by means of the recombinant microorganism, and a pharmaceutical composition, for treating immune diseases or sepsis, containing the polypeptide. A polypeptide, according to the present invention, can be bound to a complement protein C5a, with higher affinity compared to being bound to a complement protein C5a receptor which is present in nature, and inhibits the activation of same, thus being widely utilized for development of formulation for preventing or treating diseases related to a complement protein C5a.

    Method and system for simultaneously measuring surface normal vector and surface reflectance function in microscale
    460.
    发明授权
    Method and system for simultaneously measuring surface normal vector and surface reflectance function in microscale 有权

    公开(公告)号：US10281396B2

    公开(公告)日：2019-05-07

    申请号：US15427821

    申请日：2017-02-08

    Applicant: Korea Advanced Institute of Science and Technology

    Inventor： MinHyuk Kim ,  Giljoo Nam ,  Joo Ho Lee

    IPC: G01N21/55 ,  G02B21/26 ,  G02B21/06 ,  G01B11/24

    Abstract: Disclosed is a system for simultaneously measuring a surface normal vector and a surface reflection function in microscale. The system includes a light dome having a hemispherical-shaped structure and including LEDs to radiate light to an object placed therein; a macro lens installed camera arranged over the light dome to photograph the object through a hole formed at a center of the light dome under an environment in which a light is radiated from the light dome; an xyz micro-translation stage arranged under the light dome and configured to move in xyz-directions to adjust a focal distance between the macro lens installed camera and the object, and a measurement unit configured to control the light dome and the macro lens installed camera to obtain a microscale image, and configured to simultaneously measure a surface normal vector and a surface reflection function of the object based on the microscale image.

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