公开(公告)号：US10337016B2

公开(公告)日：2019-07-02

申请号：US15327596

申请日：2016-10-14

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byong-Seok Choi ,  Suk-Jo Kang ,  Janghyun Lee ,  Ji Youn Min ,  Dongmin Chun ,  Si-Eun Sung

IPC: C12N15/117 ,  A61K31/713 ,  C12N15/113

Abstract: The present disclosure provides a pharmaceutical composition for treating cancer comprising an RNA oligonucleotide having a particular sequence and structure. Specifically, when a cell line is treated with an RNA oligonucleotide having specific sequence and helical bend structure according to the present disclosure, the expression of ISG56 is increased and apoptosis of cancer cells is induced. Thus, a composition comprising the RNA oligonucleotide can be used as an anticancer agent.

公开(公告)号：US10174327B2

公开(公告)日：2019-01-08

申请号：US15165992

申请日：2016-05-26

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byong-Seok Choi ,  Mi Kyung Lee ,  Janghyun Lee ,  Suk-Jo Kang ,  Eun Byeol Park

IPC: A61K31/713 ,  A61K48/00 ,  C12N15/117

Abstract: The present disclosure provides an RNA oligonucleotide having a helical bend structure and a use thereof. Specifically, double strands formed by a complementary binding of two sequences have a helical bend structure in the RNA oligonucleotide. The RNA oligonucleotide can increase the expression of interferon-β or ISG56 and thus can be used as an immune system enhancer.