公开(公告)号：US10174327B2

公开(公告)日：2019-01-08

申请号：US15165992

申请日：2016-05-26

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byong-Seok Choi ,  Mi Kyung Lee ,  Janghyun Lee ,  Suk-Jo Kang ,  Eun Byeol Park

IPC: A61K31/713 ,  A61K48/00 ,  C12N15/117

Abstract: The present disclosure provides an RNA oligonucleotide having a helical bend structure and a use thereof. Specifically, double strands formed by a complementary binding of two sequences have a helical bend structure in the RNA oligonucleotide. The RNA oligonucleotide can increase the expression of interferon-β or ISG56 and thus can be used as an immune system enhancer.