Polypeptide binding to extracellular domain of epidermal growth factor receptor

    公开(公告)号:US10364293B2

    公开(公告)日:2019-07-30

    申请号:US15310585

    申请日:2015-05-21

    Abstract: The present invention relates to a polypeptide capable of binding specifically to the extracellular domain of epidermal growth factor receptor, a polynucleotide that encodes the polypeptide, an expression vector comprising the polynucleotide, a recombinant microorganism having the expression vector introduced therein, and a method of producing the polypeptide using the recombinant microorganism. The polypeptide according to the present invention can bind to the extracellular domain of epidermal growth factor receptor with a high binding affinity comparable to those of existing monoclonal antibodies that are widely used as targeted therapeutic agents, thereby inhibiting the activity of the epidermal growth factor receptor. The polypeptide is useful for the development of agents for the prevention or diseases associated with overexpression of epidermal growth factor receptor.

    ASYNCHRONOUS CLOCK SIGNAL GENERATOR AND SEMICONDUCTOR DEVICE FOR CORRECTING MULTI-PHASE SIGNALS USING ASYNCHRONOUS CLOCK SIGNAL

    公开(公告)号:US20190181846A1

    公开(公告)日:2019-06-13

    申请号:US16279719

    申请日:2019-02-19

    CPC classification number: H03K5/15033 H03K2005/00058

    Abstract: A semiconductor device includes a delay circuit configured to adjust a delay amount of multi-phase input signals to output multi-phase signals; a clock generator configured to output a clock signal that is not synchronized with an input signal which corresponds to one of the multi-phase signals; a detector circuit configured to generate a pulse signal corresponding to a phase difference between a reference signal corresponding to a predetermined one of the multi-phase signals and a comparison signal corresponding to a selected one of the multi-phase signals and to sample the pulse signal according to the clock signal; and a controller circuit configured to output a delay control signal for controlling a delay amount of the multi-phase input signals or controlling a delay amount of the comparison signal according to a result of calculating an output of the detector circuit and a reference value corresponding to the phase difference.

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