CONJUGATE OF VEGF-GRAB PROTEIN AND DRUG, AND USE THEREOF

    公开(公告)号:US20200148757A1

    公开(公告)日:2020-05-14

    申请号:US16625707

    申请日:2018-07-02

    Abstract: The present invention relates to a VEGF-Grab protein-drug conjugate and a use thereof and, more particularly, to a conjugate of a fusion protein in which a VEGFR1 domain 2, a VEGFR1 domain 3, and an antibody fragment are connected and a drug, a pharmaceutical composition for prevention or treatment of cancer or angiogenesis-related disease, comprising the conjugate, and a method for prevention or treatment of cancer or angiogenesis-related disease. Serving as a multi-paratopic VEGF decoy receptor, the conjugate including a VEGF-Grab protein and a drug of the present invention can be used as a multi-purpose platform for treatment of cancer or angiogenesis-related disease.

    WIDEBAND VARIABLE GAIN AMPLIFIER WITH LOW PHASE VARIATION

    公开(公告)号:US20200144978A1

    公开(公告)日:2020-05-07

    申请号:US16215864

    申请日:2018-12-11

    Abstract: A wideband variable gain amplifier (VGA) having a low phase change is disclosed. The first VGA amplifies an input signal by a current steering manner so that an amplification gain is variable. The larger a variable gain amount of the first output signal amplified by the first VGA is, the more a relative phase change amount gradually increases in either positive direction or negative direction. The second VGA further amplifies the first amplified output signal in the current steering manner so as to vary the amplification gain. As a variable gain amount of a second output signal amplified by the second VGA becomes larger, a relative phase change amount gradually increases in a direction opposite to the phase change direction of the first VGA. This opposing phase changes of the first and second VGAs are canceled against each other to provide a variable amplification gain over the wideband frequency range with a low phase change.

Patent Agency Ranking