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公开(公告)号：US10981784B2
公开(公告)日：2021-04-20
申请号：US15970688
申请日：2018-05-03
申请人： Iogen Corporation
发明人： Brian Foody
IPC分类号： C01B3/34 , C10G65/02 , C10G45/02 , C10G47/00 , C10G65/12 , C12P5/02 , C10L3/08 , C10L3/10 , C07C5/02 , C12P5/00 , G06Q30/00 , C01B3/36 , C10G45/44 , C10L1/04 , G06Q50/06
摘要： According to the present invention, organic material is converted to biogas through anaerobic digestion and the biogas is purified to yield a combustible fluid feedstock comprising methane. A fuel production facility utilizes or arranges to utilize combustible fluid feedstock to generate renewable hydrogen that is used to hydrogenate crude oil derived hydrocarbons in a process to make transportation or heating fuel. The renewable hydrogen is combined with crude oil derived hydrocarbons that have been desulfurized under conditions to hydrogenate the liquid hydrocarbon with the renewable hydrogen or alternatively, the renewable hydrogen can be added to a reactor operated so as to simultaneously desulfurize and hydrogenate the hydrocarbons. The present invention enables a party to receive a renewable fuel credit for the transportation or heating fuel.
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32.发明授权公开(公告)号：US10975394B2
公开(公告)日：2021-04-13
申请号：US16200485
申请日：2018-11-26
发明人： Zachary Q. Beck , Michael C. Miller , Caroline M. Peres , Yuliya A. Primak , Jeff P. Pucci , Derek H. Wells
IPC分类号： C12P5/00 , C12N9/04 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/18 , C12N9/88 , C12P7/02 , C12P7/04 , C12P7/42 , C12N15/70 , C12P5/02
摘要： The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms by engineering a microorganism for increased carbon flux towards mevalonate production in the following enzymatic pathways: (a) citrate synthase, (b) phosphotransacetylase, (c) acetate kinase, (d) lactate dehydrogenase, (e) malic enzyme, and (f) pyruvate dehydrogenase such that one of more of the enzyme activity is modulated. In addition, production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids can be further enhanced by the heterologous expression of the mvaE and mvaS genes (such as, but not limited to, mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus).
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33.发明授权公开(公告)号：US10961548B2
公开(公告)日：2021-03-30
申请号：US16334701
申请日：2017-09-26
IPC分类号： C12P5/00 , C12P5/02 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/82 , C12N15/09 , C12P21/02 , C12N5/10
摘要： Mutations involving amino acid substitution were introduced into various sites of diphosphomevalonate decarboxylase (MVD), thus preparing a large number of MVD variants. Then, the variants were each evaluated in terms of a catalytic activity for production of olefin compounds such as isoprene. As a result, it was found that substitution of glycine at position with a different amino acid resulted in improvement in the catalytic activity. In addition, it was found that the MVD in which arginine at position and threonine at position in addition to the position were further substituted with different amino acids, respectively, also had the high catalytic activity.
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公开(公告)号：US10954536B2
公开(公告)日：2021-03-23
申请号：US16079502
申请日：2017-02-24
申请人： CysBio ApS
摘要： The present invention generally relates to the field of biotechnology as it applies to the production of aryl sulfates using recombinant host cells. More particularly, the present invention pertains to recombinant host cells comprising (e.g., expressing) a polypeptide having aryl sulfotransferase activity, wherein said recombinant host cells have been modified to have an increased uptake of sulfate compared to identical host cells that does not carry said modification. Further provided are processes for the production of aryl sulfates, such as zosteric acid, employing such recombinant host cells.
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公开(公告)号：US20210062229A1
公开(公告)日：2021-03-04
申请号：US17095064
申请日：2020-11-11
发明人： Michael Koepke
IPC分类号： C12P5/00 , C12N15/74 , C12N9/88 , C12N9/10 , C12N9/12 , C12N9/04 , C12N15/52 , C12P7/42 , C12P9/00
摘要： The invention provides a method for producing a terpene or a precursor thereof by microbial fermentation. Typically, the method involves culturing a recombinant bacterium in the presence of a gaseous substrate whereby the bacterium produces a terpene or a precursor thereof, such as mevalonic acid, isopentenyl pyrophosphate, dimethylallyl pyrophosphate, isoprene, geranyl pyrophosphate, farnesyl pyrophosphate, and/or farnesene. The bacterium may comprise one or more exogenous enzymes, such as enzymes in mevalonate, DXS, or terpene biosynthesis pathways.
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公开(公告)号：US10927382B2
公开(公告)日：2021-02-23
申请号：US14419609
申请日：2013-08-07
发明人： Hanxiao Jiang , Adam Meadows
摘要： The present disclosure relates to the use of a switch for the production of heterologous non-catabolic compounds in microbial host cells. In one aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured under aerobic conditions followed by microaerobic conditions, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions. In another aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured in the presence of maltose followed by the reduction or absence of maltose, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions.
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公开(公告)号：US20210040490A1
公开(公告)日：2021-02-11
申请号：US16947304
申请日：2020-07-28
发明人： Zengyi Shao , Mingfeng Cao , Miguel Suastegui , Meirong Gao
摘要： The present disclosure includes methods and components for production of valuable industrial compounds in yeast. In an embodiment, the present invention provides a nucleic acid construct with increased stability for gene expression or gene editing comprising: a nucleic acid sequence encoding one or more of SEQ ID NO: 1-8 (CENs 1-8); and one or more regulatory elements functional in a yeast cell. In an embodiment of the present invention the nucleic acid constructs are vectors, preferably episomal vectors. High expression promoters, as well as methods for increasing production of compounds such as aromatics are disclosed.
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公开(公告)号：US20210010037A1
公开(公告)日：2021-01-14
申请号：US16943819
申请日：2020-07-30
摘要： The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
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公开(公告)号：US20210002672A1
公开(公告)日：2021-01-07
申请号：US16992773
申请日：2020-08-13
申请人： Manus Bio, Inc.
发明人： Ajikumar Parayil KUMARAN , Ryan LIM , Jason DONALD , Hsien-Chung TSENG , Christine Nicole S. SANTOS , Ryan PHILIPPE
摘要： The invention relates to methods and bacterial strains for making terpene and terpenoid products, the bacterial strains having improved carbon pull through the MEP pathway and to a downstream recombinant synthesis pathway.
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公开(公告)号：US20200377894A1
公开(公告)日：2020-12-03
申请号：US16900029
申请日：2020-06-12
申请人： BIOPETROLIA AB
摘要： The invention relates to engineering of acetyl-CoA metabolism in yeast and in particular to production of acetyl-CoA in a non-ethanol producing yeast lacking endogenous gene(s) encoding pyruvate decarboxylase and comprising a heterologous pathway for synthesis of cytosolic acetyl-CoA.
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