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公开(公告)号：US20220325306A1
公开(公告)日：2022-10-13
申请号：US17806046
申请日：2022-06-08
申请人： CysBio ApS
摘要： The present invention generally relates to the field of biotechnology as it applies to the production of aryl sulfates using polypeptides or recombinant cells comprising said polypeptides. More particularly, the present invention pertains to polypeptides having aryl sulfotransferase activity, recombinant host cells expressing same and processes for the production of aryl sulfates employing these polypeptides or recombinant host cells.
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公开(公告)号：US10590440B2
公开(公告)日：2020-03-17
申请号：US15502328
申请日：2015-08-21
申请人： CysBio ApS
摘要： The present invention relates to the production of hydrolyzates from a lignocellulose-containing material, and to fermentation of the hydrolyzates. More specifically, the present invention relates to the detoxification of phenolic inhibitors and toxins formed during the processing of lignocellulose-containing material by enzymatically sulfating the phenolic inhibitors and toxins using aryl sulfotranseferases.
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公开(公告)号：US11407976B2
公开(公告)日：2022-08-09
申请号：US17064203
申请日：2020-10-06
申请人： CysBio ApS
IPC分类号： C12N1/36 , C12N1/20 , C12P13/06 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/88 , C12N15/52 , C12P13/00 , C12N9/90 , C12P17/16 , C12P13/22 , C12N15/01 , C12P13/12 , C07K14/245 , C12N9/00 , C07K14/32
摘要： The present invention generally relates to the microbiological industry, and specifically to the production of L-serine or L-serine derivatives using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding for enzymes involved in the degradation of L-serine is attenuated, such as by inactivation, which makes them particularly suitable for the production of L-serine at higher yield. The present invention also provides means by which the microorganism, and more particularly a bacterium, can be made tolerant towards higher concentrations of serine. The present invention also provides methods for the production of L-serine or L-serine derivative using such genetically modified microorganisms.
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公开(公告)号：US10752923B2
公开(公告)日：2020-08-25
申请号：US15325679
申请日：2015-07-14
申请人： CysBio ApS
摘要： The present invention generally relates to the field of biotechnology as it applies to the production of hydroxycinnamic acids using polypeptides having tyrosine ammonia lyase activity. More particularly, the present invention pertains to polypeptides having tyrosine ammonia lyase activity and high substrate specificity towards tyrosine, which makes them particularly suitable in the production of p-coumaric acid and other hydroxycinnamic acids. The present invention thus provides processes for the production of p-coumaric acid and other hydroxycinnamic acids employing these polypeptides as well as recombinant host cells expressing same.
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公开(公告)号：US20210147886A1
公开(公告)日：2021-05-20
申请号：US17160149
申请日：2021-01-27
申请人： CysBio ApS
摘要： The present invention generally relates to the field of biotechnology as it applies to the production of aryl sulfates using recombinant host cells. More particularly, the present invention pertains to recombinant host cells comprising (e.g., expressing) a polypeptide having aryl sulfotransferase activity, wherein said recombinant host cells have been modified to have an increased uptake of sulfate compared to identical host cells that does not carry said modification. Further provided are processes for the production of aryl sulfates, such as zosteric acid, employing such recombinant host cells.
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公开(公告)号：US20210095245A1
公开(公告)日：2021-04-01
申请号：US17064203
申请日：2020-10-06
申请人： CysBio ApS
IPC分类号： C12N1/36 , C12N1/20 , C12P13/06 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/88 , C12N15/52 , C12P13/00 , C12N9/90 , C12P17/16 , C12P13/22 , C12N15/01 , C12P13/12 , C07K14/245 , C12N9/00 , C07K14/32
摘要： The present invention generally relates to the microbiological industry, and specifically to the production of L-serine or L-serine derivatives using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding for enzymes involved in the degradation of L-serine is attenuated, such as by inactivation, which makes them particularly suitable for the production of L-serine at higher yield. The present invention also provides means by which the microorganism, and more particularly a bacterium, can be made tolerant towards higher concentrations of serine. The present invention also provides methods for the production of L-serine or L-serine derivative using such genetically modified microorganisms.
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公开(公告)号：US10793826B2
公开(公告)日：2020-10-06
申请号：US15545563
申请日：2016-01-27
申请人： CysBio ApS
IPC分类号： C12N1/20 , C12P13/00 , C12N1/36 , C12P13/06 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/88 , C12N15/52 , C12N9/90 , C12P17/16 , C12P13/22 , C12N15/01 , C12P13/12 , C07K14/245 , C12N9/00 , C07K14/32
摘要： The present invention generally relates to the microbiological industry, and specifically to the production of L-serine or L-serine derivatives using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding for enzymes involved in the degradation of L-serine is attenuated, such as by inactivation, which makes them particularly suitable for the production of L-serine at higher yield. The present invention also provides means by which the microorganism, and more particularly a bacterium, can be made tolerant towards higher concentrations of serine. The present invention also provides methods for the production of L-serine or L-serine derivative using such genetically modified microorganisms.
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公开(公告)号：US11555212B2
公开(公告)日：2023-01-17
申请号：US17160149
申请日：2021-01-27
申请人： CysBio ApS
摘要： The present invention generally relates to the field of biotechnology as it applies to the production of aryl sulfates using recombinant host cells. More particularly, the present invention pertains to recombinant host cells comprising (e.g., expressing) a polypeptide having aryl sulfotransferase activity, wherein said recombinant host cells have been modified to have an increased uptake of sulfate compared to identical host cells that does not carry said modification. Further provided are processes for the production of aryl sulfates, such as zosteric acid, employing such recombinant host cells.
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公开(公告)号：US11306331B2
公开(公告)日：2022-04-19
申请号：US16938762
申请日：2020-07-24
申请人： CysBio ApS
摘要： The present invention generally relates to the field of biotechnology as it applies to the production of hydroxycinnamic acids using polypeptides having tyrosine ammonia lyase activity. More particularly, the present invention pertains to polypeptides having tyrosine ammonia lyase activity and high substrate specificity towards tyrosine, which makes them particularly suitable in the production of p-coumaric acid and other hydroxycinnamic acids. The present invention thus provides processes for the production of p-coumaric acid and other hydroxycinnamic acids employing these polypeptides as well as recombinant host cells expressing same.
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公开(公告)号：US10954536B2
公开(公告)日：2021-03-23
申请号：US16079502
申请日：2017-02-24
申请人： CysBio ApS
摘要： The present invention generally relates to the field of biotechnology as it applies to the production of aryl sulfates using recombinant host cells. More particularly, the present invention pertains to recombinant host cells comprising (e.g., expressing) a polypeptide having aryl sulfotransferase activity, wherein said recombinant host cells have been modified to have an increased uptake of sulfate compared to identical host cells that does not carry said modification. Further provided are processes for the production of aryl sulfates, such as zosteric acid, employing such recombinant host cells.
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