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2784 条记录 (耗时 0.057 秒)

    CYCLIN-DEPENDENT KINASE SUBSTRATE
    33.
    发明申请
    CYCLIN-DEPENDENT KINASE SUBSTRATE 审中-公开

    公开(公告)号：US20180334702A1

    公开(公告)日：2018-11-22

    申请号：US15983343

    申请日：2018-05-18

    申请人： SYSMEX CORPORATION

    发明人： Noriko Yokose ,  Masatoshi Suganuma ,  Kenta Noda ,  Naoki Nishiyama

    IPC分类号： C12Q1/48 ,  G01N33/68 ,  C07K2/00 ,  G01N33/573 ,  G01N33/50

    CPC分类号： C12Q1/485 ,  C07K14/00 ,  C12Y207/11022

    摘要： Disclosed is a cyclin-dependent kinase substrate including a polypeptide that contains an amino acid sequence represented by formula (1): R1-P (wherein R1 represents a serine residue or a threonine residue, P represents a proline residue, “—” represents a single bond, and the left side represents the N-terminal side), and satisfies the following (a1) and/or (b1): (a1) the second amino acid residue counting from the proline residue toward the N-terminal side in the formula (1) is an aromatic amino acid residue, and/or (b1) at least two amino acid residues from the proline residue toward the C-terminal side in the formula (1) are acidic amino acid residues.

    Method for quantification of allergens
    36.
    发明授权
    Method for quantification of allergens 有权

    公开(公告)号：US10023900B2

    公开(公告)日：2018-07-17

    申请号：US14198112

    申请日：2014-03-05

    申请人： ALK-Abelló A/S

    发明人： Ulla Seppälä

    IPC分类号： A61K38/00 ,  A61K38/04 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C12Q1/37 ,  G01N33/68

    CPC分类号： C12Q1/37 ,  G01N33/6848 ,  G01N2458/15 ,  G01N2800/24

    摘要： The invention relates to method for quantification of the absolute amount of allergen in an allergen sample comprising: a) providing a known amount of one or more allergen calibration standard peptide(s) having a sequence of amino acids which is identical with, and optionally unique for, a sequence to be found in the allergen to be quantified and optionally labelling said allergen calibration standard peptide(s), b) degrading the allergen sample to obtain a mixture of peptides, and optionally labelling said peptides with one or more labelling agent(s), wherein at least the peptides in the degraded allergen sample or the calibration standard peptides are labelled, and if both the peptides in the degraded allergen sample and the allergen calibration standard peptide(s) are labelled, the labelling agent(s) used for labelling the allergen calibration standard peptide(s) are different from the labelling agent(s) used for labelling the peptides of the degraded allergen sample, c) quantifying the absolute amount of allergen by correlating the amount of the allergen calibration standard peptide(s) with the amount of the corresponding peptide(s) of the degraded allergen sample by mass analysis.