公开(公告)号：US09845237B2

公开(公告)日：2017-12-19

申请号：US13148869

申请日：2010-02-26

Applicant: Hsian-Rong Tseng ,  Hao Wang ,  Shutao Wang ,  Helen Su ,  Caius G. Radu ,  Johannes Czernin

Inventor： Hsian-Rong Tseng ,  Hao Wang ,  Shutao Wang ,  Helen Su ,  Caius G. Radu ,  Johannes Czernin

IPC: A61K39/395 ,  A61K31/7088 ,  A61K31/724 ,  A61K38/00 ,  A61K38/54 ,  A61P35/00 ,  C07H21/00 ,  C07H21/02 ,  C07K14/00 ,  C07K16/00 ,  C07K2/00 ,  C08B37/16 ,  C12N15/63 ,  C12N9/96 ,  B82B3/00 ,  B82Y30/00 ,  B82Y40/00 ,  A61K47/48 ,  C08G83/00 ,  A61K47/62 ,  A61K47/69 ,  B82Y5/00

CPC classification number: B82B3/00 ,  A61K47/62 ,  A61K47/6923 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C08G83/008

Abstract: A supramolecular approach has been developed for preparation of size-controllable nanoparticles, from three different molecular building blocks.

公开(公告)号：US20140248212A1

公开(公告)日：2014-09-04

申请号：US14354770

申请日：2012-08-06

Applicant: Caius G. Radu ,  Johannes Czernin ,  Dean O. Campbell ,  Shahriar S. Yaghoubi ,  Nagichettiar Satyamurthy ,  Arnon Lavie

Inventor： Caius G. Radu ,  Johannes Czernin ,  Dean O. Campbell ,  Shahriar S. Yaghoubi ,  Nagichettiar Satyamurthy ,  Arnon Lavie

IPC: A61K51/04 ,  C12Q1/48 ,  C12N9/12

CPC classification number: A61K51/0491 ,  C12N9/1211 ,  C12Q1/485 ,  C12Y207/01021

Abstract: Embodiments of the invention include a PET/SPECT reporter gene system that uses enhanced non-immunogenic versions of a human mitochondrial thymidine kinase 2 expressed in cytoplasm to preferentially trap novel PET/SPECT radiolabeled L and D-enantiomer analogs of the natural substrate thymidine. Such highly sensitive, non-immunogenic reporter genes function in combination with a set of novel, radiolabeled probes in whole body molecular imaging applications using positron emission tomography (PET) or single photon emission computed tomography (SPECT).

Abstract translation: 本发明的实施方案包括使用在细胞质中表达的人线粒体胸苷激酶2的增强的非免疫原性型优先捕获天然底物胸苷的新型PET / SPECT放射性标记的L和D-对映异构体类似物的PET / SPECT报告基因系统。 这种高度敏感的，非免疫的报告基因与使用正电子发射断层扫描（PET）或单光子发射计算机断层摄影（SPECT）的全身分子成像应用中的一组新型放射性标记的探针结合起作用。

公开(公告)号：US09688673B2

公开(公告)日：2017-06-27

申请号：US14002964

申请日：2012-03-08

Applicant: Caius G. Radu ,  Hsiang-I Liao ,  Nagichettiar Satyamurthy ,  Johannes Czernin ,  Jennifer M. Murphy ,  David A. Nathanson

Inventor： Caius G. Radu ,  Hsiang-I Liao ,  Nagichettiar Satyamurthy ,  Johannes Czernin ,  Jennifer M. Murphy ,  David A. Nathanson

IPC: A61K51/00 ,  A61M36/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/426 ,  A61K31/44 ,  A61K31/506 ,  A61K31/513 ,  G01N33/50

CPC classification number: C07D417/12 ,  A61K31/426 ,  A61K31/44 ,  A61K31/506 ,  A61K31/513 ,  C07D417/14 ,  G01N33/5088

Abstract: The invention provides compounds that bind to deoxycytidine kinase (dCK) and compositions including pharmaceutically acceptable compositions containing the compounds. The compounds are useful in treating diseases and disorders where dCK activity is implicated such as cancer and immune disorders. The compounds also find use in clinical methodologies including positron emission tomography (PET) imaging.

公开(公告)号：US08101740B2

公开(公告)日：2012-01-24

申请号：US12234478

申请日：2008-09-19

Applicant: Caius G. Radu ,  Owen N. Witte ,  Evan David Nair-Gill ,  Nagichettiar Satyamurthy ,  Chengyi J. Shu ,  Johannes Czernin

Inventor： Caius G. Radu ,  Owen N. Witte ,  Evan David Nair-Gill ,  Nagichettiar Satyamurthy ,  Chengyi J. Shu ,  Johannes Czernin

IPC: C07H21/04

CPC classification number: A61K51/0491

Abstract: Compounds for use as PET probes and methods for synthesizing and using these, comprising [18F]D-FAC and other cytosine and adenosine analogs.

Abstract translation: 用作PET探针的化合物和用于合成和使用它们的方法，其包含[18 F] D-FAC和其他胞嘧啶和腺苷类似物。

公开(公告)号：US20130336883A1

公开(公告)日：2013-12-19

申请号：US14002964

申请日：2012-03-08

Applicant: Caius G. Radu ,  Hsiang-I Liao ,  Nagichettiar Satyamurthy ,  Johannes Czernin ,  Jennifer M. Murphy ,  David A. Nathanson

Inventor： Caius G. Radu ,  Hsiang-I Liao ,  Nagichettiar Satyamurthy ,  Johannes Czernin ,  Jennifer M. Murphy ,  David A. Nathanson

IPC: C07D417/12 ,  C07D417/14 ,  G01N33/50

CPC classification number: C07D417/12 ,  A61K31/426 ,  A61K31/44 ,  A61K31/506 ,  A61K31/513 ,  C07D417/14 ,  G01N33/5088

Abstract: The invention provides compounds that bind to deoxycytidine kinase (dCK) and compositions including pharmaceutically acceptable compositions containing the compounds. The compounds are useful in treating diseases and disorders where dCK activity is implicated such as cancer and immune disorders. The compounds also find use in clinical methodologies including positron emission tomography (PET) imaging.

Abstract translation: 本发明提供了结合脱氧胞苷激酶（dCK）的化合物和包含含有该化合物的药学上可接受的组合物的组合物。 所述化合物可用于治疗涉及dCK活性的疾病和病症，例如癌症和免疫疾病。 该化合物还用于包括正电子发射断层扫描（PET）成像在内的临床方法。

公开(公告)号：US20090105184A1

公开(公告)日：2009-04-23

申请号：US12234478

申请日：2008-09-19

Applicant: Caius G. Radu ,  Owen N. Witte ,  Evan David Nair-Gill ,  Nagichettiar Satyamurthy ,  Chengyi J. Shu ,  Johannes Czernin

Inventor： Caius G. Radu ,  Owen N. Witte ,  Evan David Nair-Gill ,  Nagichettiar Satyamurthy ,  Chengyi J. Shu ,  Johannes Czernin

IPC: A61K31/7076 ,  C07H19/048 ,  C07H19/052 ,  A61P19/02 ,  A61K31/7072 ,  C12Q1/68

CPC classification number: A61K51/0491

Abstract: Compounds for use as PET probes and methods for synthesizing and using these, comprising [18F]D-FAC and other cytosine and adenosine analogs.

Abstract translation: 用作PET探针的化合物和用于合成和使用它们的方法，其包含[18 F] D-FAC和其他胞嘧啶和腺苷类似物。

公开(公告)号：US20110305685A1

公开(公告)日：2011-12-15

申请号：US13148869

申请日：2010-02-26

Applicant: Hsian-Rong Tseng ,  Hao Wang ,  Shutao Wang ,  Helen Su ,  Caius G. Radu ,  Johannes Czernin

Inventor： Hsian-Rong Tseng ,  Hao Wang ,  Shutao Wang ,  Helen Su ,  Caius G. Radu ,  Johannes Czernin

IPC: A61K39/395 ,  C07H21/00 ,  C08B37/16 ,  C07H21/02 ,  C12N15/63 ,  A61K38/54 ,  C07K14/00 ,  C07K2/00 ,  A61K31/7088 ,  A61K38/00 ,  A61P35/00 ,  A61K31/724 ,  C07K16/00 ,  C12N9/96

CPC classification number: B82B3/00 ,  A61K47/62 ,  A61K47/6923 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C08G83/008

Abstract: A supramolecular approach has been developed for preparation of size-controllable nanoparticles, from three different molecular building blocks.

Abstract translation: 已经开发了用于制备来自三种不同分子结构单元的尺寸可控纳米颗粒的超分子方法。

公开(公告)号：US06552348B2

公开(公告)日：2003-04-22

申请号：US09737119

申请日：2000-12-14

Applicant: Simon R. Cherry ,  Johannes Czernin ,  Niraj K. Doshi ,  Yiping Shao ,  Robert W. Silverman

Inventor： Simon R. Cherry ,  Johannes Czernin ,  Niraj K. Doshi ,  Yiping Shao ,  Robert W. Silverman

IPC: G01T1164

CPC classification number: G01T1/202 ,  A61B6/037 ,  B33Y80/00 ,  G01T1/2985

Abstract: A detector for use in a dedicated PET scanner for cancer applications, particularly breast cancer applications, using a LSO scintillator, a lightguide coupling arrangement, and an efficient way to construct the scintillator array, which provides a flexible imaging system for breast cancer applications with high sensitivity and high spatial resolution in a compact, cost effective, design.

Abstract translation: 用于癌症应用的专用PET扫描仪的检测器，特别是使用LSO闪烁体的乳腺癌应用，光导耦合装置和构建闪烁体阵列的有效方式，其为具有高的乳腺癌应用提供灵活的成像系统 敏感性和高空间分辨率在一个紧凑，成本有效的设计。