公开(公告)号：US12016779B2

公开(公告)日：2024-06-25

申请号：US16337893

申请日：2017-09-29

申请人： UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： Jay R. Lieberman ,  William Pannell ,  Yong Chen ,  Xuan Song ,  Sofia Bougioukli

IPC分类号： A61F2/30 ,  A61F2/28 ,  A61K38/18 ,  A61L27/10 ,  A61L27/38 ,  A61L27/54 ,  B33Y10/00 ,  B33Y80/00

CPC分类号： A61F2/30942 ,  A61F2/28 ,  A61K38/1875 ,  A61L27/10 ,  A61L27/3834 ,  A61L27/54 ,  A61F2002/30235 ,  A61F2002/30677 ,  A61F2002/30784 ,  A61F2310/00293 ,  A61L2300/414 ,  A61L2430/02 ,  B33Y10/00 ,  B33Y80/00

摘要： A method for repairing a bone defect of a patient includes providing a ceramic scaffold configured for filling the bone defect, loading the scaffold with growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation, placing the ceramic scaffold with the growth factor transduced cells in or across the bone defect, and stabilizing the ceramic scaffold with the growth factor transduced cells in the patient until the bone defect is healed. An assembly for repairing a bone defect includes a ceramic scaffold configured for spanning the bone defect and a culture of live growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation loaded onto the ceramic scaffold.

公开(公告)号：US20240199794A1

公开(公告)日：2024-06-20

申请号：US18553600

申请日：2022-03-25

申请人： University of Massachusetts

发明人： Jie Song ,  Jing Zhang

IPC分类号： C08G63/08 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  C07D319/12

CPC分类号： C08G63/08 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  C07D319/12 ,  A61L2300/41 ,  A61L2400/16 ,  C08G2230/00 ,  C08G2280/00

摘要： The invention provides novel compounds and polymers with pendant aspirin, and degradable and biocompatible compositions, medical devices and implants, and methods of making and use thereof.

公开(公告)号：US20240199793A1

公开(公告)日：2024-06-20

申请号：US18017948

申请日：2021-08-05

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Wei Shen ,  Ronald A. Siegel ,  Sudipta Panja

IPC分类号： C08G63/08 ,  A61K38/47 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  C08L87/00

CPC分类号： C08G63/08 ,  A61K38/47 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  C08L87/005 ,  C12Y302/01017 ,  C08L2201/06

摘要： Methods including providing a block copolymer, the block copolymer comprising at least a polycaprolactone (PCL) block; and a second block being amorphous and having a glass transition temperature less than 30° C.; and subjecting the block copolymer to thermal processing at a temperature less than 100° C. Articles and thermoprocessing methods utilizing such block copolymers are also disclosed herein.

公开(公告)号：US20240197464A1

公开(公告)日：2024-06-20

申请号：US18288087

申请日：2022-04-25

申请人： Sanofi

发明人： Lionel Vedrine ,  Christina Laskar ,  Pradeep Dhal ,  Craig Harvey Nelson ,  Mark Robson Humphries ,  Carys Eleri Lee ,  Nicholas Oliver Harding

IPC分类号： A61F2/02 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56

CPC分类号： A61F2/022 ,  A61L27/3804 ,  A61L27/54 ,  A61L27/56 ,  A61F2230/0069 ,  A61L2300/414

摘要： An implantable device for providing a therapeutic agent includes a container configured to contain multiple cells capable of producing the therapeutic agent within an interior region of the container. The container defines first pores defined by an interior wall portion of the container and second pores defined by an exterior wall portion of the container. The first pores have a first average size that (i) allows passage of the therapeutic agent and oxygen through the first pores and (ii) prevents passage of immune cells through the first pores. The second pores have a second average size that is larger than the first average size, and the second pores are sized to promote vascularization and oxygen transfer along the exterior wall portion.

公开(公告)号：US20240191007A1

公开(公告)日：2024-06-13

申请号：US18587211

申请日：2024-02-26

申请人： b-ONE Medical (Suzhou) Co., Ltd. ,  b-ONE Medical Biotech Corporation ,  b-ONE Ortho, Corp

发明人： Zongtao ZHANG

IPC分类号： C08F110/02 ,  A61K31/355 ,  A61L27/16 ,  A61L27/54

CPC分类号： C08F110/02 ,  A61K31/355 ,  A61L27/16 ,  A61L27/54 ,  A61L2430/24 ,  C08F2500/01 ,  C08F2810/20

摘要： The invention relates to a surface gradient cross-linked method of a ultra-high molecular weight polyethylene and the application thereof. The surface gradient crosslinked method of ultrahigh molecular weight polyethylene includes a n ultra-high molecular weight polyethylene surface photoinitiator diffusion step and an ultraviolet light irradiation crosslinking step. In this method, the photoinitiator is diffused deeply into the surface of ultra-high molecular weight polyethylene, the body material shows a gradient cross-linking from the surface to the inside after ultraviolet irradiation so that the whole bulk has a high toughness and the surface there of has a high wear resistance.

公开(公告)号：US20240189483A1

公开(公告)日：2024-06-13

申请号：US17755432

申请日：2020-10-30

申请人： Allegro 3D, Inc.

发明人： Wei Zhu ,  Wei Wei

IPC分类号： A61L27/38 ,  A61L27/52 ,  A61L27/54 ,  B33Y50/00 ,  B33Y70/00 ,  B33Y80/00

CPC分类号： A61L27/3878 ,  A61L27/3834 ,  A61L27/52 ,  A61L27/54 ,  B33Y80/00 ,  A61L2300/414 ,  A61L2400/12 ,  A61L2430/32 ,  B33Y50/00 ,  B33Y70/00

摘要： Disclosed are systems, methods, and devices for tissue regenerative implants. In some aspects, a nerve tissue regeneration implant article includes an exterior shell; a plurality of fascicle structures disposed in an interior region of the exterior shell, where each fascicle structure includes a hollow region between a proximal end and a distal end, such that a fascicle structure is configured to facilitate and guide axonal growth along at least a portion of the fascicle structure between the proximal end and the distal end; and a plurality of vascularizable passages along the exterior shell, wherein the vascularizable passages are configured to allow vascular tissue to infiltrate the implant article, such that the implant article is able to facilitate nerve regeneration by enabling exchange of nutrients, oxygen, and/or waste to axons within the plurality of fascicle structures via the vascular tissue that infiltrates the implant article through the plurality of vascularizable passages.

公开(公告)号：US20240189372A1

公开(公告)日：2024-06-13

申请号：US18022760

申请日：2021-08-24

申请人： BRANDENBURGISCHE TECHNSCH UNIVERSITÄT COTTBUS-SENFTENBERG

发明人： Friedrich JUNG ,  Jan-Heiner KÜPPER

IPC分类号： A61K35/748 ,  A61K38/16 ,  A61L27/28 ,  A61L27/54 ,  A61L31/08 ,  A61L31/16 ,  A61P9/14

CPC分类号： A61K35/748 ,  A61K38/164 ,  A61L27/28 ,  A61L27/54 ,  A61L31/08 ,  A61L31/16 ,  A61P9/14 ,  A61L2300/30 ,  A61L2300/416

摘要： The present invention refers to beneficial effects of an extract of Arthrospira or phycobiliproteins with respect to endothelial cells and related diseases.
Hereto, in a first aspect, the present invention relates to a pharmaceutical composition, in particular a coating comprising an extract of Arthrospira or phycobiliproteins as an active ingredient for implantable devices due to said beneficial effects.
Hereto, in a second aspect, the present invention relates to a pharmaceutical preparation/composition comprising an extract of Arthrospira or phycobiliproteins as an active ingredient for therapeutic and prophylactic treatment or prevention of neo-intimal hyperplasia, restenosis, thrombosis, embolism, bacterial infections, preferably bloodstream infections, primary bacteremia and sepsis due to said beneficial effects.

公开(公告)号：US20240183081A1

公开(公告)日：2024-06-06

申请号：US18441730

申请日：2024-02-14

申请人： TECRES S.p.A.

发明人： Giovanni FACCIOLI ,  Renzo SOFFIATTI

IPC分类号： D01D5/08 ,  A61L27/16 ,  A61L27/54 ,  B33Y10/00 ,  B33Y70/10

CPC分类号： D01D5/082 ,  A61L27/16 ,  A61L27/54 ,  B33Y10/00 ,  B33Y70/10 ,  A61L2300/104 ,  A61L2300/232 ,  A61L2300/25 ,  A61L2300/406 ,  D10B2321/0211 ,  D10B2401/13 ,  D10B2509/00

摘要： Method for the obtainment of a thread made of a material biocompatible and implantable in the human body: a thread for the obtainment of a device implantable in the human body.

公开(公告)号：US20240181135A1

公开(公告)日：2024-06-06

申请号：US18286541

申请日：2022-04-26

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Charles K.F. Chan ,  Michael T. Longaker ,  Thomas Ambrosi ,  Owen Marecic ,  Irving L. Weissman ,  Adrian Mcardle

IPC分类号： A61L27/52 ,  A61L27/26 ,  A61L27/54 ,  C08L1/02 ,  C08L5/08 ,  C08L67/04 ,  C08L89/06

CPC分类号： A61L27/52 ,  A61L27/26 ,  A61L27/54 ,  C08L1/02 ,  C08L5/08 ,  C08L67/04 ,  C08L89/06 ,  A61L2300/256 ,  A61L2300/604 ,  A61L2430/02

摘要： Aged skeletal stem cells are targeted for reactivation by administration of a combination of a bone morphogenetic protein (BMP) and an inhibitor of CSF1, which combination of factors may be topically administered to a targeted skeletal site. In some embodiments the topical administration comprises placement of an implant, e.g. a matrix, gel, scaffold, etc. for localized delivery of the factor at the targeted skeletal site.

公开(公告)号：US20240181134A1

公开(公告)日：2024-06-06

申请号：US18345212

申请日：2023-06-30

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Arvydas Usas ,  Karin Payne ,  Thomas Payne ,  Ronald Jankowski ,  Johnny Huard

IPC分类号： A61L27/38 ,  A61K35/12 ,  A61K35/38 ,  A61L27/36 ,  A61L27/54 ,  A61L27/58 ,  C12N5/077 ,  C12N11/02

CPC分类号： A61L27/3895 ,  A61K35/38 ,  A61L27/3629 ,  A61L27/365 ,  A61L27/3826 ,  A61L27/3847 ,  A61L27/54 ,  A61L27/58 ,  C12N5/0652 ,  C12N5/0658 ,  C12N5/0659 ,  C12N11/02 ,  A61K35/12 ,  A61L2300/64 ,  A61L2430/02 ,  A61L2430/40 ,  C12N2533/92

摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.