公开(公告)号：US20170278689A1

公开(公告)日：2017-09-28

申请号：US15618959

申请日：2017-06-09

Applicant: SHIMADZU CORPORATION

Inventor： Li DING ,  Mikhail SUDAKOV ,  Sumio KUMASHIRO

IPC: H01J49/02 ,  H01J49/42

CPC classification number: H01J49/027 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/406 ,  H01J49/408 ,  H01J49/4245

Abstract: An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.

公开(公告)号：US09741551B2

公开(公告)日：2017-08-22

申请号：US15332734

申请日：2016-10-24

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Alexander Alekseevich Makarov

IPC: H01J49/00 ,  H01J49/28 ,  H01J49/02 ,  H01J49/38 ,  H01J49/42 ,  H01J49/08

CPC classification number: H01J49/282 ,  H01J49/027 ,  H01J49/08 ,  H01J49/38 ,  H01J49/4245

Abstract: Mass analyzers and methods of ion detection for a mass analyzer are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.

公开(公告)号：US09698002B2

公开(公告)日：2017-07-04

申请号：US15131117

申请日：2016-04-18

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Jan-Peter Hauschild ,  Oliver Lange ,  Ulf Fröhlich ,  Andreas Wieghaus ,  Alexander Kholomeev ,  Alexander Makarov

IPC: H01J49/04 ,  H01J49/00 ,  H01J49/38 ,  H01J49/42

CPC classification number: H01J49/4265 ,  H01J49/0031 ,  H01J49/027 ,  H01J49/04 ,  H01J49/38 ,  H01J49/4245 ,  H01J49/425

Abstract: A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyzer; the batch of ions accumulated in the mass analyzer is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyzer is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyzer; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyzer.

公开(公告)号：US20170040152A1

公开(公告)日：2017-02-09

申请号：US15332734

申请日：2016-10-24

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Alexander Alekseevich MAKAROV

IPC: H01J49/28 ,  H01J49/08 ,  H01J49/02

CPC classification number: H01J49/282 ,  H01J49/027 ,  H01J49/08 ,  H01J49/38 ,  H01J49/4245

Abstract: Mass analyzers and methods of ion detection for a mass analyzer are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.

Abstract translation: 提供了用于质量分析仪的质量分析仪和离子检测方法。 静电场发生器提供静电场，使离子包沿着一个方向振荡。 在比离子振荡的周期短的持续时间内检测脉冲瞬态信号，或使用具有明显小于离子谐波运动的跨度的宽度的脉冲检测电极。 还检测到谐波瞬态信号。 然后基于脉冲瞬态信号和谐波瞬态信号来识别关于质荷比的离子强度。

公开(公告)号：US20160336165A1

公开(公告)日：2016-11-17

申请号：US15107177

申请日：2014-12-06

Applicant: DH TECHNOLOGIES DEVELOPMENT PTD. LTD.

Inventor： Mircea GUNA

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/02 ,  H01J49/06

CPC classification number: H01J49/4245 ,  H01J49/0031 ,  H01J49/027 ,  H01J49/063 ,  H01J49/26 ,  H01J49/282

Abstract: Systems and methods are provided for performing multiplex electrostatic linear ion trap mass spectrometry. A first beam of ions is received and the first beam is split into N beams of ions using a beam splitter. N is two or more. Ions are received from only one of the N beams of ions at each entrance aperture of N entrance apertures of an electrostatic linear ion trap (ELIT). Ions from each entrance aperture of the N entrance apertures are trapped in separate linear flight paths using the ELIT, producing N seperate linear flight paths. Ion oscillations in the N separate linear flight paths are measured at substantially the same time using the ELIT. The ELIT uses two concentric mirrors with N apertures to trap ions in the N separate linear flight paths. The ELIT uses an image current detector with N apertures to the measure the ion oscillations.

Abstract translation: 提供了用于执行多重静电线性离子阱质谱的系统和方法。 接收第一束离子，并且使用分束器将第一束分离成N束离子。 N是两个或更多。 在静电线性离子阱（ELIT）的N个入口孔的每个入口孔处仅从N个离子束中的一个接收离子。 来自N个入口孔的每个入口孔的离子被使用ELIT捕获在分开的线性飞行路径中，产生N个单独的线性飞行路径。 使用ELIT在几乎相同的时间内测量N个单独的线性飞行路径中的离子振荡。 ELIT使用两个具有N个孔的同心镜来捕获N个单独的线性飞行路径中的离子。 ELIT使用具有N个孔径的图像电流检测器来测量离子振荡。

公开(公告)号：US20150364304A1

公开(公告)日：2015-12-17

申请号：US14305676

申请日：2014-06-16

Applicant: Bruker Daltonik GmbH

Inventor： Evgeny NIKOLAEV

IPC: H01J49/00 ,  H01J49/42 ,  H01J49/36

CPC classification number: H01J49/0036 ,  H01J49/0031 ,  H01J49/027 ,  H01J49/36 ,  H01J49/38 ,  H01J49/425

Abstract: The invention provides a method for acquiring a mass spectrum with a Fourier transform mass spectrometer, wherein analyte ions and additional reporter ions oscillate at mass specific frequencies in a measuring cell of the frequency mass spectrometer and interact by Coulomb forces; the image current signal induced by the reporter ion is measured; and mass signals of the analyte ions are determined from a sideband signal of the reporter ions in the frequency domain or from the instantaneous frequency of the reporter ions in the time domain.

Abstract translation: 本发明提供了一种利用傅里叶变换质谱仪获取质谱的方法，其中分析物离子和附加的报道离子在质谱特定频率上在频率质谱仪的测量单元中振荡并与库仑力相互作用; 测量报告离子诱导的图像电流信号; 并且分析物离子的质量信号由频域中的报道离子的边带信号或时域中报道离子的瞬时频率确定。

公开(公告)号：US09035245B2

公开(公告)日：2015-05-19

申请号：US14277933

申请日：2014-05-15

Applicant: Carl Zeiss Microscopy GmbH

Inventor： Albrecht Glasmachers ,  Michel Aliman

IPC: H01J37/05 ,  H01J49/02 ,  H01J49/42 ,  H01J37/244 ,  H01J37/252

CPC classification number: H01J37/05 ,  H01J37/244 ,  H01J37/252 ,  H01J49/022 ,  H01J49/027 ,  H01J49/424 ,  H01J2237/028 ,  H01J2237/057

Abstract: A device for mass selective determination of at least one ion or of a plurality of ions is used, for example, in a measuring apparatus having an ion trap. The ion trap has a ring electrode having a first opening. A first electrode is arranged at the first opening. Furthermore, an amplifier for providing a radio-frequency storage signal for the ion trap and a first transformer are provided, said first transformer being connected to the amplifier and the first electrode in such a way that the radio-frequency storage signal is coupled into the first electrode via the first transformer.

Abstract translation: 例如，在具有离子阱的测量装置中使用用于质量选择性测定至少一种离子或多种离子的装置。 离子阱具有具有第一开口的环形电极。 第一电极设置在第一开口处。 此外，提供了一种用于提供用于离子阱的射频存储信号和第一变压器的放大器，所述第一变压器以这样的方式连接到放大器和第一电极，使得射频存储信号耦合到 第一电极经由第一变压器。

公开(公告)号：US20130270433A1

公开(公告)日：2013-10-17

申请号：US13838357

申请日：2013-03-15

Applicant: SHIMADZU CORPORATION

Inventor： Li Ding ,  Ranjan Badheka

IPC: H01J49/00 ,  G06T5/00

CPC classification number: H01J49/0004 ,  G06T5/00 ,  H01J49/0036 ,  H01J49/027

Abstract: A method of processing a plurality of image charge/current signals representative of trapped ions undergoing oscillatory motion, e.g. for use in an ion trap mass spectrometer. The method includes producing a linear combination of the plurality of image charge/current signals using a plurality of predetermined coefficients, the predetermined coefficients having been selected so as to suppress at least one harmonic component of the image charge/current signals within the linear combination of the plurality of image charge/current signals.

Abstract translation: 一种处理表示经历振荡运动的被俘获的离子的多个图像充电/电流信号的方法，例如， 用于离子阱质谱仪。 该方法包括使用多个预定系数产生多个图像充电/电流信号的线性组合，所选择的预定系数以便抑制在线性组合内的图像充电/电流信号的至少一个谐波分量 多个图像充电/电流信号。

公开(公告)号：US20130264473A1

公开(公告)日：2013-10-10

申请号：US13993316

申请日：2011-12-14

Applicant: Alexander A. Makarov

Inventor： Alexander A. Makarov

IPC: H01J49/28

CPC classification number: H01J49/282 ,  H01J49/027 ,  H01J49/08 ,  H01J49/38 ,  H01J49/4245

Abstract: Mass analysers and methods of ion detection for a mass analyser are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.

Abstract translation: 提供了用于质量分析仪的质量分析仪和离子检测方法。 静电场发生器提供静电场，使离子包沿着一个方向振荡。 在比离子振荡的周期短的持续时间内检测脉冲瞬态信号，或使用具有明显小于离子谐波运动的跨度的宽度的脉冲检测电极。 还检测到谐波瞬态信号。 然后基于脉冲瞬态信号和谐波瞬态信号来识别关于质荷比的离子强度。

公开(公告)号：US08362418B2

公开(公告)日：2013-01-29

申请号：US12990688

申请日：2009-05-29

Applicant: Wei Xu ,  William Chappell ,  Zheng Ouyang ,  Robert Graham Cooks

Inventor： Wei Xu ,  William Chappell ,  Zheng Ouyang ,  Robert Graham Cooks

IPC: B01D59/44

CPC classification number: H01J49/426 ,  H01J49/027

Abstract: The invention herein generally relates to non-destructive, high order harmonic ion motion image current detection. In certain embodiments, ion motion corresponding to high order harmonic frequencies, instead of the secular frequencies, is detected using image current detection with a constant excitation applied to the waveform signal.

Abstract translation: 本发明一般涉及非破坏性高次谐波离子运动图像电流检测。 在某些实施例中，使用施加到波形信号的恒定激励的图像电流检测来检测对应于高次谐波频率而不是长期频率的离子运动。