公开(公告)号：US09214322B2

公开(公告)日：2015-12-15

申请号：US13993590

申请日：2011-12-13

Applicant: Alexander Kholomeev ,  Alexander A. Makarov

Inventor： Alexander Kholomeev ,  Alexander A. Makarov

IPC: H01J49/00 ,  H01J49/02 ,  H01J43/00 ,  H01J49/40

CPC classification number: H01J49/0031 ,  H01J43/00 ,  H01J49/025 ,  H01J49/40

Abstract: A detection system and a method for detecting ions which have been separated in a time-of-flight (TOF) mass analyzer, comprising an amplifying arrangement for converting ions into packets of secondary particles and amplifying the packets of secondary particles, wherein the amplifying arrangement is arranged so that each packet of secondary particles produces at least a first output and a second output separated in time and so that during the delay between producing the first and second output the first output produced by a packet of secondary particles is used for modulating the second output produced by the same packet. An increased dynamic range of detection and protection of the detection system against intense ion pulses is thereby provided.

Abstract translation: 一种用于检测在飞行时间质谱仪（TOF）质量分析仪中已分离的离子的检测系统和方法，包括用于将离子转换成二次粒子的分组并放大次级粒子的分组的放大装置，其中放大装置 布置成使得每个二次粒子的分组产生至少第一输出和在时间上分离的第二输出，并且使得在产生第一和第二输出之间的延迟期间，由二次粒子的分组产生的第一输出用于调制 第二个输出由同一个数据包产生。 从而提供了检测系统对强离子脉冲的动态检测范围的增加。

公开(公告)号：US09058964B2

公开(公告)日：2015-06-16

申请号：US12992557

申请日：2009-06-01

Applicant: Alexander A. Makarov ,  Alexander Kholomeev

Inventor： Alexander A. Makarov ,  Alexander Kholomeev

IPC: H01J49/02 ,  H01J49/00

CPC classification number: H01J49/022 ,  H01J49/0031 ,  Y10T307/696

Abstract: A method of switching between two modes of power supply to a mass analyzer is provided. In a first mode of operation, operated for a first predefined time duration, a first power supply, coupled to the mass analyzer, generates a first nonzero potential, while a second power supply, disconnected from the mass analyzer, generates a second non-zero potential. In a second mode of operation, operated for a second predefined time duration, the second potential is coupled to the mass analyzer, while the first power supply, disconnected from the mass analyzer, generates the first potential. These predefined time durations are selected such that only one of: the first potential; and the second potential is coupled to the mass analyzer at any time, and such that the first and second modes of operation are carried out at least once within a predetermined length of time.

Abstract translation: 提供了一种在质量分析器的两种供电模式之间切换的方法。 在第一操作模式中，在第一预定义的持续时间内操作，耦合到质量分析器的第一电源产生第一非零电位，而与质量分析器断开的第二电源产生第二非零 潜在。 在第二操作模式中，在第二预定持续时间内操作，第二电位耦合到质量分析器，而从质量分析器断开的第一电源产生第一电位。 选择这些预定义的持续时间，使得仅一个：第一个电位; 并且第二电位在任何时间耦合到质量分析器，并且使得第一和第二操作模式在预定时间长度内进行至少一次。

公开(公告)号：US08847154B2

公开(公告)日：2014-09-30

申请号：US13333948

申请日：2011-12-21

Applicant: Eloy R. Wouters ,  Alexander A. Makarov ,  R. Paul Atherton ,  Jean Jacques Dunyach

Inventor： Eloy R. Wouters ,  Alexander A. Makarov ,  R. Paul Atherton ,  Jean Jacques Dunyach

IPC: H01J49/26 ,  H01J49/42 ,  H01J49/04

CPC classification number: H01J49/0404 ,  B23H7/02 ,  B23H9/14

Abstract: An ion transfer tube for a mass spectrometer comprises a core member and a first jacket tube member at least partially enclosing the core member and providing one or more channels therethrough. A method of forming an ion transfer tube, comprises: providing a first jacket tube member having a length and an internal bore, the internal bore passing along the length and defining an interior surface of circular cross section; removing at least one portion of the first jacket tube member adjacent to the interior surface so as to form at least one groove, channel, slot, recess or embayment of or in the interior surface; and providing a core member within the bore of the jacket tube member such that remnant portions of the interior surface of circular cross section mate against portions of an exterior surface of the core member.

Abstract translation: 用于质谱仪的离子传递管包括芯构件和至少部分地包围芯构件并且提供穿过其中的一个或多个通道的第一护套管构件。 一种形成离子转移管的方法，包括：提供具有长度和内孔的第一套管构件，所述内孔沿着所述长度通过并限定圆形横截面的内表面; 移除与所述内表面相邻的所述第一套管构件的至少一部分，以便形成所述内表面中或所述内表面中的至少一个凹槽，通道，槽，凹槽或沉积物; 并且在所述护套管构件的所述孔内提供芯构件，使得所述圆形横截面的内表面的残留部分与所述芯构件的外表面的部分配合。

公开(公告)号：US08686350B2

公开(公告)日：2014-04-01

申请号：US13853603

申请日：2013-03-29

Applicant: Alexander A. Makarov ,  Oliver Lange ,  Stevan R. Horning

Inventor： Alexander A. Makarov ,  Oliver Lange ,  Stevan R. Horning

IPC: H01J49/00

CPC classification number: H01J49/0009 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/14 ,  H01J49/4265

Abstract: This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analyzed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analyzed; accumulating in the ion store a sample of another type of ions to be analyzed; and mass analyzing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.

Abstract translation: 本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。 具体地说，尽管并非排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。 提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。

公开(公告)号：US08680481B2

公开(公告)日：2014-03-25

申请号：US12909507

申请日：2010-10-21

Applicant: Anastassios Giannakopulos ,  Alexander A. Makarov

Inventor： Anastassios Giannakopulos ,  Alexander A. Makarov

IPC: H01J49/40 ,  H01J49/02

CPC classification number: H01J49/025 ,  H01J49/40 ,  H01J2237/2444

Abstract: Embodiments of the invention provide a detection apparatus for detecting charged particles having a secondary particle generator for generating secondary charged particles in response to receiving incoming charged particles, a charged particle detector for receiving and detecting secondary charged particles generated by the secondary particle generator, a photon generator for generating photons in response to receiving secondary charged particles generated by the secondary particle generator, and a photon detector for detecting the photons generated by the photon generator.

Abstract translation: 本发明的实施例提供了一种用于检测带有二次粒子发生器的带电粒子的检测装置，用于响应于接收进入的带电粒子而产生二次带电粒子，用于接收和检测由二次粒子发生器产生的二次带电粒子的带电粒子检测器， 用于响应于由二次粒子发生器产生的接收二次带电粒子而产生光子的发生器，以及用于检测由光子发生器产生的光子的光子检测器。

公开(公告)号：US20130264473A1

公开(公告)日：2013-10-10

申请号：US13993316

申请日：2011-12-14

Applicant: Alexander A. Makarov

Inventor： Alexander A. Makarov

IPC: H01J49/28

CPC classification number: H01J49/282 ,  H01J49/027 ,  H01J49/08 ,  H01J49/38 ,  H01J49/4245

Abstract: Mass analysers and methods of ion detection for a mass analyser are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.

Abstract translation: 提供了用于质量分析仪的质量分析仪和离子检测方法。 静电场发生器提供静电场，使离子包沿着一个方向振荡。 在比离子振荡的周期短的持续时间内检测脉冲瞬态信号，或使用具有明显小于离子谐波运动的跨度的宽度的脉冲检测电极。 还检测到谐波瞬态信号。 然后基于脉冲瞬态信号和谐波瞬态信号来识别关于质荷比的离子强度。

公开(公告)号：US08513595B2

公开(公告)日：2013-08-20

申请号：US13164693

申请日：2011-06-20

Applicant: Alexander A. Makarov ,  Stevan Horning

Inventor： Alexander A. Makarov ,  Stevan Horning

IPC: H01J49/26 ,  H01J27/02

CPC classification number: H01J49/009 ,  H01J49/425

Abstract: A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.

公开(公告)号：US08410424B2

公开(公告)日：2013-04-02

申请号：US13008790

申请日：2011-01-18

Applicant: Alexander A. Makarov ,  Oliver Lange ,  Stevan R. Horning

Inventor： Alexander A. Makarov ,  Oliver Lange ,  Stevan R. Horning

IPC: B01D59/44

CPC classification number: H01J49/0009 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/14 ,  H01J49/4265

Abstract: This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.

Abstract translation: 本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。 具体地说，尽管并非排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。 提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。

公开(公告)号：US08278618B2

公开(公告)日：2012-10-02

申请号：US12996226

申请日：2009-06-03

Applicant: Alexander A. Makarov ,  Eduard V. Denisov ,  Wilko Balschun ,  Dirk Nolting ,  Jens Griep-Raming

Inventor： Alexander A. Makarov ,  Eduard V. Denisov ,  Wilko Balschun ,  Dirk Nolting ,  Jens Griep-Raming

IPC: H01J49/40

CPC classification number: H01J49/0422 ,  H01J49/0031 ,  H01J49/0045 ,  H01J49/0072 ,  H01J49/0081 ,  H01J49/0481 ,  H01J49/06 ,  H01J49/26 ,  H01J49/40

Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.

Abstract translation: 提供了在质谱仪中操作充气碰撞池的方法。 碰撞单元具有纵向轴线。 导致离子进入碰撞池。 在碰撞单元内产生捕获场，以便将离子捕获在碰撞池的捕获体积内，捕获体积由捕获场限定并沿着纵轴延伸。 捕获的离子在碰撞单元中被处理，并且使用电极布置提供DC电位梯度，导致沿着捕获体积的轴向长度的所有点处的非零电场，从而使经处理的离子离开碰撞 细胞。 沿着捕集体积的轴向长度的电场具有不大于其平均值的标准偏差。

公开(公告)号：US20110017907A1

公开(公告)日：2011-01-27

申请号：US12809867

申请日：2008-12-22

Applicant: Alexander A. Makarov ,  Dmitry E. Grinfield ,  Mikhail A. Monastyrskiy

Inventor： Alexander A. Makarov ,  Dmitry E. Grinfield ,  Mikhail A. Monastyrskiy

IPC: H01J49/40

CPC classification number: H01J49/406 ,  H01J49/061 ,  H01J49/405

Abstract: The present invention provides a method of reflecting ions in a multireflection time of flight mass spectrometer comprising providing an ion mirror having a plurality of electrodes, the ion mirror having a cross section with a first, minor axis (Y) and a second, major axis (X) each perpendicular to a longitudinal axis (Z) of the ion mirror which lies generally in the direction of time of flight separation of the ions in the mirror; guiding ions towards the ion mirror; applying a voltage to the electrodes so as to create an electric field which: (a) causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror which contains the longitudinal (Z) and major axes (X) of the mirror; (b) causes the ions to reflect in the ion mirror; and (c) causes the ions to exit the ion mirror in a direction such that the mean trajectory of ions passing through the ion mirror has a component of movement in a direction (Y) perpendicular to and diverging from the said plane of symmetry thereof.

Abstract translation: 本发明提供一种在多反射飞行时间质谱仪中反射离子的方法，包括提供具有多个电极的离子反射镜，所述离子反射镜具有具有第一短轴（Y）和第二长轴（Y）的横截面 （X），每个垂直于离子镜的纵向轴线（Z），其通常位于反射镜中的离子的飞行时间分离方向上; 引导离子到离子镜; 向电极施加电压以产生电场：（a）使离子的平均轨迹与包含纵向（Z）和长轴（X）的离子镜的对称平面相交， 镜子; （b）使离子在离子反射镜中反射; 和（c）使得离子离开离子反射镜的方向，使得通过离子镜的离子的平均轨迹具有与所述对称平面垂直的方向（Y）和与其对称的发散方向的运动分量。