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    Insulin-like gene in prawns and uses thereof
    31.
    发明授权
    Insulin-like gene in prawns and uses thereof 有权
    虾类中的胰岛素样基因及其用途

    公开(公告)号：US08440878B2

    公开(公告)日：2013-05-14

    申请号：US13277088

    申请日：2011-10-19

    申请人： Amir Sagi ,  Tomer Ventura

    发明人： Amir Sagi ,  Tomer Ventura

    IPC分类号： A01K67/027 ,  C12N15/00 ,  C12N15/11

    CPC分类号： C07K14/62 ,  A01K67/033 ,  A01K2207/05 ,  A01K2227/70 ,  C07K14/43509 ,  C07K14/65

    摘要： The present invention relates to a nucleic acid molecule encoding an insulin-like factor of the androgenic gland of the freshwater prawn Macrobrachium rosenbergii (M. rosenbergii). The present invention further relates to methods of silencing the expression of the insulin-like factor gene in decapod crustaceans order, particularly in M. rosenbergii, useful for producing male monosex populations.

    摘要翻译： 本发明涉及编码淡水虾罗氏沼虾（Rosenbergii）的雄激素腺的胰岛素样因子的核酸分子。 本发明进一步涉及使十字头甲壳类动物中特别是罗氏沼虾中的胰岛素样因子基因的表达沉默的方法，其可用于产生雄性单体种群。

    CRUSTACEAN EXPRESSION VECTOR
    32.
    发明申请
    CRUSTACEAN EXPRESSION VECTOR 审中-公开
    表达式表达向量

    公开(公告)号：US20110269225A1

    公开(公告)日：2011-11-03

    申请号：US13176026

    申请日：2011-07-05

    申请人： ARUN K. DHAR ,  F.C. THOMAS ALLNUTT

    发明人： ARUN K. DHAR ,  F.C. THOMAS ALLNUTT

    IPC分类号： C12N15/85

    CPC分类号： C12N15/85 ,  A01K2227/70 ,  A01K2267/0393 ,  C12N2799/021 ,  C12N2800/90

    摘要： Methods and constructs for genetic manipulation of one or more of shrimp, shellfish, mollusks, and fish are disclosed. The nucleic acid construct includes a promoter and an internal ribosome entry site of an insect picomavirus, such as a cricket paralysis-like picomavirus. One or more open reading frames can be operably associated with one or both of the promoter and the internal ribosome entry site, and one or more proteins or protein subunits can be expressed upon introduction of the construct into a host cell, such as into a shrimp. Method for producing immortalized crustacean cell lines using enhancer elements derived from shrimp and/or shrimp viruses are also described.

    摘要翻译： 公开了一种或多种虾，贝类，软体动物和鱼的遗传操作的方法和构造。 核酸构建体包括一种启动子和一种诸如板球麻痹状皮莫瓦病毒之类的皮肤微病毒病毒的内部核糖体进入位点。 一个或多个开放阅读框可以与启动子和内部核糖体进入位点中的一个或两个可操作地相关联，并且一个或多个蛋白质或蛋白质亚基可以在将构建体引入宿主细胞时表达，例如进入虾 。 还描述了使用源自虾和/或虾病毒的增强子元件生产永生化甲壳类细胞系的方法。

    MODIFIED ARTHROPOD AND METHOD OF USE
    33.
    发明申请
    MODIFIED ARTHROPOD AND METHOD OF USE 审中-公开
    改良的牙齿和使用方法

    公开(公告)号：US20110145939A1

    公开(公告)日：2011-06-16

    申请号：US12817933

    申请日：2010-06-17

    申请人： Scott Leslie O'Neill

    发明人： Scott Leslie O'Neill

    IPC分类号： A01K67/033 ,  C12N1/20 ,  C12N1/36 ,  A01N63/00 ,  A01P7/00 ,  A01P7/04

    CPC分类号： C12N15/87 ,  A01K67/033 ,  A01K67/0337 ,  A01K2227/70 ,  A01K2227/706 ,  A01K2267/02 ,  A01N63/00 ,  C12N15/01 ,  C12R1/01

    摘要： A modified arthropod, an arthropod-modifying bacterium, and use thereof as an agent for control of diseases transmitted by arthropods, particularly mosquitoes, is provided. More specifically, an isolated arthropod-adapted Wolbachia bacterium capable of modifying one or more biological properties of a mosquito host is provided. The modified arthropod may be characterized as having a shortened life-span, a reduced ability to transmit disease, a reduced susceptibility to a pathogen, a reduced fecundity, and/or a reduced ability to feed from a host, when compared to a corresponding wild-type arthropod.

    摘要翻译： 提供了一种改良的节肢动物，节肢动物修饰细菌及其作为控制由节肢动物，特别是蚊子传播的疾病的药剂的用途。 更具体地，提供能够改变蚊子宿主的一种或多种生物学特性的分离的节肢动物适应的沃尔巴克氏杆菌细菌。 修饰的节肢动物的特征可以在于与相应的野生型相比具有缩短的寿命，降低的传播能力，降低的对病原体的易感性，降低的繁殖力和/或降低的从宿主进食的能力 型节肢动物

    Crustacean Expression Vector
    38.
    发明申请
    Crustacean Expression Vector 有权
    甲壳类动物表达载体

    公开(公告)号：US20070292952A1

    公开(公告)日：2007-12-20

    申请号：US11587770

    申请日：2005-04-15

    申请人： Arun Dhar ,  Thomas Allnutt

    发明人： Arun Dhar ,  Thomas Allnutt

    IPC分类号： C12N15/86

    CPC分类号： C12N15/85 ,  A01K2227/70 ,  A01K2267/0393 ,  C12N2799/021 ,  C12N2800/90

    摘要： Methods and constructs for genetic manipulation of one or more of shrimp, shellfish, mollusks, and fish are disclosed. The nucleic acid construct includes a promoter and an internal ribosome entry site of an insect picomavirus, such as a cricket paralysis-like picomavirus. One or more open reading frames can be operably associated with one or both of the promoter and the internal ribosome entry site, and one or more proteins or protein subunits can be expressed upon introduction of the construct into a host cell, such as into a shrimp. Method for producing immortalized crustacean cell lines using enhancer elements derived from shrimp and/or shrimp viruses are also described.

    摘要翻译： 公开了一种或多种虾，贝类，软体动物和鱼的遗传操作的方法和构造。 核酸构建体包括一种启动子和一种诸如板球麻痹状皮莫瓦病毒之类的皮肤微病毒病毒的内部核糖体进入位点。 一个或多个开放阅读框可以与启动子和内部核糖体进入位点中的一个或两个可操作地相关联，并且一个或多个蛋白质或蛋白质亚基可以在将构建体引入宿主细胞时表达，例如进入虾 。 还描述了使用源自虾和/或虾病毒的增强子元件生产永生化甲壳类细胞系的方法。

    Transgenic aquatic invertebrates as a bioreactor for production of recombinant polypeptides
    39.
    发明申请
    Transgenic aquatic invertebrates as a bioreactor for production of recombinant polypeptides 审中-公开
    转基因水生无脊椎动物作为重组多肽生产的生物反应器

    公开(公告)号：US20070248742A1

    公开(公告)日：2007-10-25

    申请号：US11601613

    申请日：2006-11-16

    申请人： Hao Fan

    发明人： Hao Fan

    IPC分类号： A01K67/033 ,  A23L1/325

    CPC分类号： A01K67/0338 ,  A01K2217/05 ,  A01K2227/70 ,  A01K2267/02

    摘要： Disclosed are transgenic aquatic invertebrate for use as bioreactors to express heterologous recombinant polypeptides and its application. Also included are methods for producing transgenic Brine species and Brine cysts, and methods for expressing heterologous proteins is said cysts. The method includes introducing the foreign genes into cysts of a Brine shrimp, identification of transgenic individual and the generation of a parthenogenesis culture for transgene expression. The transgenic aquatic invertebrates described will be used as an alternative method for the low cost large-scale production of recombinant proteins, such as therapeutic proteins, polypeptide based vaccine or anti-microbial proteins, proteins for use as a food source in humans, animals and aquaculture.

    摘要翻译： 公开了用作生物反应器来表达异源重组多肽的转基因水生无脊椎动物及其应用。 还包括生产转基因盐水种类和盐水囊肿的方法，表达异源蛋白质的方法就是囊肿。 该方法包括将外来基因引入盐水虾的囊肿中，鉴定转基因个体和产生转基因表达的单性生殖培养物。 所述的转基因水生无脊椎动物将被用作低成本大规模生产重组蛋白质的替代方法，所述重组蛋白质例如治疗性蛋白质，基于多肽的疫苗或抗微生物蛋白质，用作人类，动物中的食物来源的蛋白质 水产养殖。