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31.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases 有权与谷氨酰脯氨酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09574187B2
公开(公告)日：2017-02-21
申请号：US14686280
申请日：2015-04-14
Applicant: aTyr Pharma, Inc. , Pangu BioPharma Limited
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC classification number: C07K16/40 , A61K9/0019 , A61K9/14 , A61K38/53 , A61K39/3955 , A61K47/60 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/569 , C07K2317/94 , C12N9/93 , C12N9/96
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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公开(公告)号：US09322009B2
公开(公告)日：2016-04-26
申请号：US14592431
申请日：2015-01-08
Applicant: aTyr Pharma Inc. , Pangu Biopharma Limited
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC classification number: C07K16/40 , A61K38/00 , C07K2317/24 , C07K2317/622 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/01007 , G01N33/573 , G01N33/68 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US09127268B2
公开(公告)日：2015-09-08
申请号：US13514952
申请日：2010-12-10
Applicant: Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kristi Helen Piehl , Fei Hong , Kyle P. Chiang , Wei Zhang , Alina He
Inventor： Jeffry Dean Watkins , Alain Philippe Vasserot , Leslie Ann Greene , Ryan Andrew Adams , Kristi Helen Piehl , Fei Hong , Kyle P. Chiang , Wei Zhang , Alina He
IPC: C12N9/00 , A61K38/53 , A61K39/395 , A61K45/06
CPC classification number: A61K38/53 , A61K39/39541 , A61K45/06 , C12N9/93 , C12Y601/01021
Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
Abstract translation: 提供包含氨基-tRNA合成酶多肽的炎症和其它细胞应答调节组合物，包括其活性片段和/或变体。 还提供了使用这些组合物来治疗受益于炎症疾病或病症等炎症调节的病症的方法。
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34.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases 有权与谷氨酰脯氨酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09062301B2
公开(公告)日：2015-06-23
申请号：US13696048
申请日：2011-05-04
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
CPC classification number: C07K16/40 , A61K9/0019 , A61K9/14 , A61K38/53 , A61K39/3955 , A61K47/60 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/569 , C07K2317/94 , C12N9/93 , C12N9/96
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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35.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases 有权与酪氨酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09029506B2
公开(公告)日：2015-05-12
申请号：US13818929
申请日：2011-08-25
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC classification number: C07K16/40 , A61K38/00 , A61K38/16 , C07K2317/24 , C07K2317/622 , C07K2317/92 , C12N9/93 , C12Y601/01 , C12Y601/01001 , G01N33/573 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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Patent Agency Ranking
36.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase 有权与半胱氨酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US08980253B2
公开(公告)日：2015-03-17
申请号：US13643755
申请日：2011-04-26
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC classification number: C07K16/40 , A61K38/00 , A61K39/39591 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C12N9/93 , C12Y601/01016 , G01N33/573 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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37.发明授权Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases 有权用于治疗自身免疫性和炎性疾病的组氨酰-tRNA合成酶公开(公告)号：US08835387B2
公开(公告)日：2014-09-16
申请号：US13769100
申请日：2013-02-15
Applicant: aTyr Pharma, Inc. , Pangu BioPharma Limited
Inventor： Kyle P. Chiang , Elisabeth Gardiner , Ching-Fun Lau , Wing-Sze Lo , Jeffrey Greve , Melissa Ashlock , John D. Mendlein
CPC classification number: C12N9/93 , A61K38/16 , A61K38/17 , A61K38/53 , A61K39/0008 , A61K48/00 , A61K48/005 , C12Q1/6883 , C12Q2600/158 , C12Y601/01021 , G01N33/573 , G01N2333/9015 , G01N2800/52 , Y02A50/473
Abstract: The present invention relates generally to compositions and methods comprising histidyl-tRNA synthetase polypeptides or other specific blocking agents for the treatment autoimmune diseases and other inflammatory diseases, including those related to Jo-1 antibodies.
Abstract translation: 本发明一般涉及包含组氨酰-tRNA合成酶多肽或用于治疗自身免疫性疾病和其它炎性疾病的其它特异性阻断剂的组合物和方法，包括与Jo-1抗体相关的那些。
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38.发明申请COMPOSITIONS AND METHODS COMPRISING HISTIDYL-TRNA SYNTHETASE SPLICE VARIANTS HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES 有权包含具有非经济生物活性的HISTIDYL-TRNA SYNTHETASE SPLICE变量的组合物和方法公开(公告)号：US20130243766A1
公开(公告)日：2013-09-19
申请号：US13766659
申请日：2013-02-13
Applicant: ATYR PHARMA, INC. , PANGU BIOPHARMA LIMITED
Inventor： Jie Zhou , Ching-Fun Lau , Zhiwen Xu , Wing-Sze Lo , Kristi Helen Piehl , Leslie Ann Greene
IPC: C12N9/00
CPC classification number: C07K16/40 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C12N9/93 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12Q1/6876 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Y601/01021 , G01N33/573 , G01N2333/9015 , G01N2500/04 , G01N2500/10
Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
Abstract translation: 提供了具有非规范生物活性的分离的组氨酰-tRNA合成酶剪接变体多核苷酸和多肽，以及与其相关的组合物和方法。
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39.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF METHIONYL-TRNA SYNTHETASES 有权与甲硫氨酸合成酶蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20130236440A1
公开(公告)日：2013-09-12
申请号：US13696044
申请日：2011-05-03
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
CPC classification number: C07K16/40 , A61K38/53 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/0101 , G01N33/573 , G01N33/68 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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公开(公告)号：US20120064082A1
公开(公告)日：2012-03-15
申请号：US13162559
申请日：2011-06-16
Applicant: Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
Inventor： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
IPC: A61K39/395 , A61P7/00 , C07K16/18
CPC classification number: C07K16/40 , A61K38/53 , A61K39/39533 , C07K2317/20 , C07K2317/33 , A61K2300/00
Abstract: Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis.
Abstract translation: 提供造血调节组合物，其包含氨酰-tRNA合成酶多肽，包括其活性片段和/或变体，以及包含相关试剂如抗体和其它结合剂的组合物。 还提供了使用这些组合物治疗受益于造血细胞调节的病症的方法。
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