公开(公告)号：US08753281B2

公开(公告)日：2014-06-17

申请号：US13618520

申请日：2012-09-14

Applicant: Joseph M. Schmitt ,  Christopher Petersen ,  Toro Ohasi ,  Tetsuya Nakamatsu

Inventor： Joseph M. Schmitt ,  Christopher Petersen ,  Toro Ohasi ,  Tetsuya Nakamatsu

IPC: A61B8/14 ,  A61B6/00

CPC classification number: A61B5/0066 ,  A61B5/0095 ,  A61B5/6852 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4461

Abstract: In one aspect, the invention relates to a probe. The probe includes a sheath, a flexible, bi-directionally rotatable, optical subsystem positioned within the sheath, the optical subsystem comprising a transmission fiber, the optical subsystem capable of transmitting and collecting light of a predetermined range of wavelengths along a first beam having a predetermined beam size. The probe also includes an ultrasound subsystem, the ultrasound subsystem positioned within the sheath and adapted to propagate energy of a predetermined range of frequencies along a second beam having a second predetermined beam size, wherein a portion of the first and second beams overlap a region during a scan.

Abstract translation: 一方面，本发明涉及一种探针。 探针包括位于护套内的护套，柔性双向可旋转的光学子系统，光学子系统包括传输光纤，该光学子系统能够沿着具有第一光束的第一光束发射和收集预定波长范围的光 预定的光束尺寸。 所述探针还包括超声子系统，所述超声子系统位于护套内并且适于沿具有第二预定光束尺寸的第二光束传播预定频率范围的能量，其中第一和第二光束的一部分在 扫描。

公开(公告)号：US20140142427A1

公开(公告)日：2014-05-22

申请号：US13792910

申请日：2013-03-11

Applicant: LIGHTLAB IMAGING, INC.

Inventor： Christopher Petroff

IPC: A61M25/00 ,  A61B5/00

CPC classification number: A61B5/0073 ,  A61B5/0066 ,  A61B5/0215 ,  A61B5/6852 ,  A61B8/12 ,  A61M39/10 ,  A61M39/24 ,  A61M2025/0024 ,  A61M2025/0035 ,  A61M2039/242

Abstract: In part, the invention relates to catheters, methods, and blood clearing technologies suitable for use in an optical coherence tomography system. The optical coherence tomography system includes a control system, a probe including a catheter defining a lumen and a rotatable optical fiber located within the lumen, a fluid cartridge holder in communication with the lumen of the probe, a pump to move fluid from the fluid cartridge to the lumen of the probe; and a motor configured to rotate and pull the optical fiber through the lumen of a blood vessel. The pump and the motor are controlled by the control system. The catheter can include a wall that bounds the lumen of the probe, which defines a flush port and includes a valve in fluid communication with the flush port, the valve configured to permit fluid from the lumen to pass through the wall.

Abstract translation: 部分地，本发明涉及适用于光学相干断层摄影系统的导管，方法和血液清除技术。 光学相干断层摄影系统包括控制系统，包括限定内腔的导管和位于内腔内的可旋转光纤的探针，与探针的内腔连通的流体盒保持器，用于将流体从流体盒 到探头的内腔; 以及电动机，其构造成使光纤旋转并拉动通过血管的内腔。 泵和电机由控制系统控制。 导管可以包括限定探针的内腔的壁，该壁限定了冲洗口，并且包括与冲洗口流体连通的阀，所述阀构造成允许来自内腔的流体通过壁。

公开(公告)号：US20140114182A1

公开(公告)日：2014-04-24

申请号：US13841399

申请日：2013-03-15

Applicant: LightLab Imaging, Inc.

Inventor： Christopher L. Petersen ,  Joseph M. Schmitt

IPC: A61B5/00 ,  A61B8/12

CPC classification number: A61B5/0066 ,  A61B5/0095 ,  A61B5/6852 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4461

Abstract: In one aspect, the invention relates to a probe. The probe includes a sheath, a flexible, bi-directionally rotatable, optical subsystem positioned within the sheath, the optical subsystem comprising a transmission fiber, the optical subsystem capable of transmitting and collecting light of a predetermined range of wavelengths along a first beam having a predetermined beam size. The probe also includes an ultrasound subsystem, the ultrasound subsystem positioned within the sheath and adapted to propagate energy of a predetermined range of frequencies along a second beam having a second predetermined beam size, wherein a portion of the first and second beams overlap a region during a scan.

Abstract translation: 一方面，本发明涉及一种探针。 探针包括位于护套内的护套，柔性双向可旋转的光学子系统，光学子系统包括传输光纤，该光学子系统能够沿着具有第一光束的第一光束发射和收集预定波长范围的光 预定的光束尺寸。 所述探针还包括超声子系统，所述超声子系统位于护套内并且适于沿具有第二预定光束尺寸的第二光束传播预定频率范围的能量，其中第一和第二光束的一部分在 扫描。

公开(公告)号：US20130310698A1

公开(公告)日：2013-11-21

申请号：US13780611

申请日：2013-02-28

Applicant: Neil Judell ,  Robert Steinbrecher ,  Joel Friedman ,  Christopher Petersen

Inventor： Neil Judell ,  Robert Steinbrecher ,  Joel Friedman ,  Christopher Petersen

IPC: A61B5/00

CPC classification number: A61B5/0073 ,  A61B5/0066 ,  A61B5/02007 ,  A61B5/6852 ,  A61B5/7285

Abstract: In one aspect, the invention relates to a computer-implemented method of triggering optical coherence tomography data collection. The method includes collecting optical coherence tomography data with respect to a vessel using an optical coherence tomography probe disposed in the vessel; determining a clearing radius and a quality value for each frame of optical coherence tomography data collected for the vessel using a computer; determining if a blood clearing state has occurred using at least one clearing radius and at least one quality value; and generating a trigger signal in response to the blood clearing state.

Abstract translation: 一方面，本发明涉及触发光学相干层析成像数据采集的计算机实现的方法。 该方法包括使用设置在容器中的光学相干断层摄影探针来收集关于血管的光学相干断层摄影数据; 使用计算机为所述船舶收集的光学相干断层摄影数据的每帧确定清除半径和质量值; 使用至少一个清除半径和至少一个质量值来确定是否已经发生血液清除状态; 以及响应于血液清除状态产生触发信号。

公开(公告)号：US08581643B1

公开(公告)日：2013-11-12

申请号：US13284122

申请日：2011-10-28

Applicant: Joseph M. Schmitt

Inventor： Joseph M. Schmitt

IPC: H03L7/06

CPC classification number: H03L7/104 ,  H03L7/07 ,  H03L7/0805 ,  H03L7/093

Abstract: In part, the invention relates to an optical coherence tomography system that includes one or more phased-locked loop circuits. In one embodiment, the phased-locked loop circuit includes a phase detector, a loop filter, and a voltage controlled oscillator wherein the phased-locked loop circuit is configured to generate a sample clock. The optical coherence tomography system can include an analog to digital converter having a sample clock input, an interferometric signal input, and a sample data output, the analog to digital converter configured to receive the sample clock and sample OCT data in response thereto. In one embodiment, the phased-locked loop circuit is configured to lock on a first signal in less than or equal to about 1 microseconds.

Abstract translation: 部分地，本发明涉及一种包括一个或多个锁相环电路的光学相干断层摄影系统。 在一个实施例中，锁相环电路包括相位检测器，环路滤波器和压控振荡器，其中锁相环电路被配置为产生采样时钟。 光学相干断层摄影系统可以包括具有采样时钟输入，干涉信号输入和采样数据输出的模数转换器，模数转换器被配置为接收采样时钟并响应于此采样OCT数据。 在一个实施例中，锁相环电路被配置为在小于或等于约1微秒内锁定第一信号。

公开(公告)号：US20120250028A1

公开(公告)日：2012-10-04

申请号：US13077075

申请日：2011-03-31

Applicant: Joseph M. Schmitt ,  Desmond Adler

Inventor： Joseph M. Schmitt ,  Desmond Adler

IPC: G02B6/27 ,  F21V11/00 ,  G01B9/02 ,  G02B6/26 ,  G02B6/35

CPC classification number: G02B6/2861 ,  G01B9/02004 ,  G01B9/02091 ,  G02B6/2808 ,  G02B6/3502

Abstract: In one embodiment, the invention relates to an apparatus for increasing the repetition rate in a light source. The apparatus includes a first optical coupler comprising a first arm, a second arm and a third arm; a first mirror in optical communication with the second arm of the first optical coupler; and a first optical delay line having a first end in optical communication with the third arm of the first optical coupler and a second end in optical communication with a second mirror, wherein light entering the first arm of the first optical coupler leaves the first arm of the first optical coupler either delayed by an amount (τ) or substantially undelayed.

Abstract translation: 在一个实施例中，本发明涉及一种用于增加光源中的重复率的装置。 该装置包括：第一光耦合器，包括第一臂，第二臂和第三臂; 与第一光耦合器的第二臂光学通信的第一反射镜; 以及第一光学延迟线，其具有与第一光耦合器的第三臂光学通信的第一端和与第二反射镜光学连通的第二端，其中进入第一光耦合器的第一臂的光离开第一臂的第一臂 第一光耦合器延迟量（τ）或基本上不延迟。

公开(公告)号：US20120236883A1

公开(公告)日：2012-09-20

申请号：US13048441

申请日：2011-03-15

Applicant: Desmond Adler

Inventor： Desmond Adler

IPC: H01S3/10

CPC classification number: H01S3/1062 ,  G01B9/02004 ,  G01B9/02069 ,  G01B9/02091 ,  H01S3/06791 ,  H01S3/08013 ,  H01S3/08059 ,  H01S3/083 ,  H01S3/1109 ,  H01S5/1071 ,  H01S5/146

Abstract: In one embodiment, the invention relates to systems, methods and devices for improving the operation of an electromagnetic radiation source or component thereof. In one embodiment, the source is a laser source. A Fourier domain mode locked laser can be used in various embodiments. The sources described herein can be used in an optical coherence tomography (OCT) system such as a frequency domain OCT system. In one embodiment, laser coherence length is increased by compensating for dispersion. A frequency shifter can also be used in one embodiment to compensate for a tunable filter induced Doppler shift.

Abstract translation: 在一个实施例中，本发明涉及用于改善电磁辐射源或其部件的操作的系统，方法和装置。 在一个实施例中，源是激光源。 在各种实施例中可以使用傅里叶域模式锁定激光器。 本文描述的来源可用于光学相干层析成像（OCT）系统，例如频域OCT系统。 在一个实施例中，通过补偿色散来增加激光相干长度。 在一个实施例中也可以使用移频器来补偿可调滤波器引起的多普勒频移。

公开(公告)号：US20120075691A1

公开(公告)日：2012-03-29

申请号：US13308120

申请日：2011-11-30

Applicant: Robert Alexander Huber ,  Christoph Eigenwillig ,  Benjamin Biedermann

Inventor： Robert Alexander Huber ,  Christoph Eigenwillig ,  Benjamin Biedermann

IPC: H01S3/13

CPC classification number: A61B5/0059 ,  A61B5/0066 ,  G02B5/20 ,  G02B5/284 ,  G02B26/002 ,  H01S3/08009 ,  H01S3/08059 ,  H01S3/105

Abstract: In at least one embodiment of the wavelength-tunable light source, it comprises an output source, which is capable in operation of generating electromagnetic radiation. Furthermore, the light source has a wavelength-selective first filter element, which is situated downstream from the output source. Moreover, the light source contains a first amplifier medium, which is situated downstream from the first filter element and is capable of at least partial amplification of the radiation emitted by the output source. The light source further comprises at least one wavelength-selective second filter element, which is situated downstream from the first amplifier medium, the second filter element having an optical spacing to the first filter element. The first filter element and the at least one second filter element are tunable via a control unit, which the light source has.

Abstract translation: 在波长可调光源的至少一个实施例中，它包括能够产生电磁辐射的输出源。 此外，光源具有位于输出源下游的波长选择性第一滤光元件。 此外，光源包含第一放大器介质，其位于第一滤光元件的下游，并且能够至少部分地放大由输出源发射的辐射。 光源还包括位于第一放大器介质下游的至少一个波长选择性第二滤光器元件，第二滤光元件具有与第一滤光元件的光学间隔。 第一过滤器元件和至少一个第二过滤器元件可通过光源具有的控制单元来调节。

公开(公告)号：US07916387B2

公开(公告)日：2011-03-29

申请号：US12008403

申请日：2008-01-10

Applicant: Joseph M. Schmitt

Inventor： Joseph M. Schmitt

IPC: H01S5/00 ,  H01S3/098

CPC classification number: G01B9/02091 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/02004 ,  G01B9/02043 ,  G01B9/02069 ,  G01B2290/25 ,  G01B2290/60 ,  H01S3/1062 ,  H01S5/141 ,  H01S5/146 ,  H01S5/5036

Abstract: In one embodiment of the invention, a semiconductor optical amplifier (SOA) in a laser ring is chosen to provide low polarization-dependent gain (PDG) and a booster semiconductor optical amplifier, outside of the ring, is chosen to provide high polarization-dependent gain. The use of a semiconductor optical amplifier with low polarization-dependent gain nearly eliminates variations in the polarization state of the light at the output of the laser, but does not eliminate the intra-sweep variations in the polarization state at the output of the laser, which can degrade the performance of the SS-OCT system.

Abstract translation: 在本发明的一个实施例中，选择激光环中的半导体光放大器（SOA）以提供低偏振相关增益（PDG），并且选择在环外部的升压半导体光放大器以提供高偏振相关 获得。 使用具有低偏振相关增益的半导体光放大器几乎消除了在激光器的输出处的光的偏振状态的变化，但是不消除激光器的输出处的偏振状态的扫描内变化， 这可能会降低SS-OCT系统的性能。

公开(公告)号：US07848791B2

公开(公告)日：2010-12-07

申请号：US11351896

申请日：2006-02-10

Applicant: Joseph M. Schmitt ,  Amanda Koski ,  Michael Atlas ,  Christopher Petersen

Inventor： Joseph M. Schmitt ,  Amanda Koski ,  Michael Atlas ,  Christopher Petersen

IPC: A61B6/00

CPC classification number: G01B9/02091 ,  A61B5/0066 ,  A61B5/6852 ,  G01B9/0205 ,  G01B2290/65 ,  G01B2290/70 ,  G01N21/474 ,  G01N21/4795 ,  G01N21/8507 ,  G01N2021/1787 ,  G01N2021/8514 ,  G01N2021/8528 ,  G02B6/262

Abstract: In one aspect, the invention relates to an imaging probe. The imaging probe includes an elongate body having a proximal end and distal end, the elongate body adapted to enclose a portion of a slidable optical fiber, the optical fiber having a longitudinal axis; and a first optical assembly attached to a distal end of the fiber. The first optical assembly includes a beam director adapted to direct light emitted from the fiber to a plane at a predetermined angle to the longitudinal axis, a linear actuator disposed at the proximal portion of the elongated body, the actuator adapted to affect relative linear motion between the elongate body and the optical fiber; and a second optical assembly located at the distal portion of the elongate body and attached thereto, the second optical assembly comprising a reflector in optical communication with the first optical assembly, the reflector adapted to direct the light to a position distal to the elongate body.

Abstract translation: 一方面，本发明涉及一种成像探针。 成像探头包括具有近端和远端的细长主体，细长主体适于包围可滑动光纤的一部分，光纤具有纵向轴线; 以及附接到纤维的远端的第一光学组件。 第一光学组件包括光束引导器，其适于将从光纤发射的光引导到与纵向轴线成预定角度的平面;线性致动器，设置在细长主体的近端部分处，致动器适于影响 细长体和光纤; 以及第二光学组件，其位于细长主体的远端部分并附接到其上，第二光学组件包括与第一光学组件光学连通的反射器，反射器适于将光引导到远离细长主体的位置。