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1.发明授权公开(公告)号：US12285240B2
公开(公告)日：2025-04-29
申请号：US17968927
申请日：2022-10-19
Applicant: LightLab Imaging, Inc.
Inventor： Joseph M. Schmitt , Joel M. Friedman , Christopher Petroff , Amr Elbasiony
Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.
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公开(公告)号：US12178612B2
公开(公告)日：2024-12-31
申请号：US18367588
申请日：2023-09-13
Applicant: LightLab Imaging, Inc.
Inventor： Joseph M. Schmitt , Chenyang Xu
IPC: A61B5/00
Abstract: A method and apparatus for determining properties of a tissue or tissues imaged by optical coherence tomography (OCT). In one embodiment the backscatter and attenuation of the OCT optical beam is measured and based on these measurements and indicium such as color is assigned for each portion of the image corresponding to the specific value of the backscatter and attenuation for that portion. The image is then displayed with the indicia and a user can then determine the tissue characteristics. In an alternative embodiment the tissue characteristics is classified automatically by a program given the combination of backscatter and attenuation values.
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3.发明公开公开(公告)号：US20240099590A1
公开(公告)日：2024-03-28
申请号：US18523226
申请日：2023-11-29
Applicant: LightLab Imaging, Inc.
Inventor： Joseph M. Schmitt , Joel M. Friedman , Christopher Petroff , Amr Elbasiony
CPC classification number: A61B5/02007 , A61B5/0066 , A61B5/0073 , A61B5/0084
Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.
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公开(公告)号：US20230414176A1
公开(公告)日：2023-12-28
申请号：US18367588
申请日：2023-09-13
Applicant: LightLab Imaging, Inc.
Inventor： Joseph M. Schmitt , Chenyang Xu
IPC: A61B5/00
CPC classification number: A61B5/6852 , A61B5/0066 , A61B5/7264
Abstract: A method and apparatus for determining properties of a tissue or tissues imaged by optical coherence tomography (OCT). In one embodiment the backscatter and attenuation of the OCT optical beam is measured and based on these measurements and indicium such as color is assigned for each portion of the image corresponding to the specific value of the backscatter and attenuation for that portion. The image is then displayed with the indicia and a user can then determine the tissue characteristics. In an alternative embodiment the tissue characteristics is classified automatically by a program given the combination of backscatter and attenuation values.
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公开(公告)号：US11241154B2
公开(公告)日：2022-02-08
申请号：US15466246
申请日：2017-03-22
Applicant: LightLab Imaging, Inc.
Inventor： Desmond Adler , Joseph M. Schmitt , Mattias Dahlberg , Par Gustafsson , Ulrik Hubinette , Magnus Samuelsson , Johan Svanerudh
Abstract: In part, the invention relates to an image data collection system. The system can include an interferometer having a reference arm that includes a first optical fiber of length of L1 and a sample arm that includes a second optical fiber of length of L2 and a first rotary coupler configured to interface with an optical tomography imaging probe, wherein the rotary coupler is in optical communication with the sample arm. In one embodiment, L2 is greater than about 5 meters. The first optical fiber and the second optical fiber can both be disposed in a common protective sheath. In one embodiment, the system further includes an optical element configured to adjust the optical path length of the reference arm, wherein the optical element is in optical communication with the reference arm and wherein the optical element is transmissive or reflective.
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Patent Agency Ranking
公开(公告)号：US11058308B2
公开(公告)日：2021-07-13
申请号：US16206033
申请日：2018-11-30
Applicant: LightLab Imaging, Inc.
Inventor： Joseph M. Schmitt , Christopher Petroff
IPC: A61B5/00 , A61B5/0215 , A61B5/02
Abstract: An optical coherence tomography system and method with integrated pressure measurement. In one embodiment the system includes an interferometer including: a wavelength swept laser; a source arm in communication with the wavelength swept laser; a reference arm in communication with a reference reflector, a first photodetector having a signal output; a detector arm in communication with the first photodetector, a probe interlace; a sample arm in communication with a first optical connector of the probe interface; an acquisition and display system comprising: an A/D converter having a signal input in communication with the first photodetector signal output and a signal output; a processor system in communication with the A/D converter signal output; and a display in communication with the processor system; and a probe comprising a pressure sensor and configured for connection to the first optical connector of the probe interface, wherein the pressure transducer comprises an optical pressure transducer.
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7.发明申请公开(公告)号：US20180306569A1
公开(公告)日：2018-10-25
申请号：US16017545
申请日：2018-06-25
Applicant: LightLab Imaging, Inc.
Inventor： Joseph M. Schmitt , Victor Grinberg
CPC classification number: G01B9/02055 , G01B9/02004 , G01B9/02044 , G01B9/02074 , G01B9/02083 , H03G3/3084 , H04B10/616 , H04B10/671
Abstract: In part, aspects of the invention relate to methods, apparatus, and systems for intensity and/or pattern line noise reduction in a data collection system such as an optical coherence tomography system that uses an electromagnetic radiation source and interferometric principles. In one embodiment, the noise is intensity noise or line pattern noise and the source is a laser such as a swept laser. One or more attenuators responsive to one or more control signals can be used in conjunction with an analog or digital feedback network in one embodiment.
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公开(公告)号：US20250082206A1
公开(公告)日：2025-03-13
申请号：US18960195
申请日：2024-11-26
Applicant: LightLab Imaging, Inc.
Inventor： Christopher Petroff , Joseph M. Schmitt
Abstract: In part, the invention relates to methods, apparatus, and systems suitable for determining a fractional flow reserve (FFR) and variations of modifications thereof One embodiment relates to a method and apparatus for obtaining a corrected FFR in a vessel having a stenosis. In one aspect, the invention relates to an apparatus for measuring corrected FFR of a vessel having a stenosis. In one embodiment, the apparatus includes a probe comprising an optical coherence tomography assembly and a pressure assembly; and a processor in communication with the optical coherence tomography assembly and the pressure assembly. In one embodiment, the pressure assembly measures values of pressure in predetermined locations the vessel and communicates them to the processor. In one embodiment, a dual guidewire is used to reduce the interference in the pressure measurement.
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公开(公告)号：US12193789B2
公开(公告)日：2025-01-14
申请号：US16937117
申请日：2020-07-23
Applicant: LightLab Imaging, Inc.
Inventor： Christopher Petroff , Joseph M. Schmitt
Abstract: In part, the invention relates to methods, apparatus, and systems suitable for determining a fractional flow reserve (FFR) and variations of modifications thereof One embodiment relates to a method and apparatus for obtaining a corrected FFR in a vessel having a stenosis. In one aspect, the invention relates to an apparatus for measuring corrected FFR of a vessel having a stenosis. In one embodiment, the apparatus includes a probe comprising an optical coherence tomography assembly and a pressure assembly; and a processor in communication with the optical coherence tomography assembly and the pressure assembly. In one embodiment, the pressure assembly measures values of pressure in predetermined locations the vessel and communicates them to the processor. In one embodiment, a dual guidewire is used to reduce the interference in the pressure measurement.
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公开(公告)号：US11923067B2
公开(公告)日：2024-03-05
申请号：US14115527
申请日：2013-03-12
Applicant: Lightlab Imaging, Inc.
Inventor： Joseph M. Schmitt , Hiram Bezerra , Christopher Petroff , Ajay Gopinath
CPC classification number: G16H30/20 , A61B5/0066 , A61B5/02007 , A61B5/1076 , A61F2/86 , G16H20/40 , A61B2090/061 , A61F2/82 , A61F2230/0069 , A61F2240/001 , A61F2250/006
Abstract: In part, the invention relates to a method for sizing a stent for placement in a vessel. In one embodiment, the method includes the steps of: dividing the vessel into a plurality of segments, each segment being defined as the space between branches of the vessel; selecting a starting point that appears to have substantially no disease; defining the diameter at this point to be the maximum diameter; calculating the maximal diameter of the next adjacent segment according to a power law; measuring the actual diameter of the next adjacent segment; selecting either the calculated maximum diameter or the measured maximum diameter depending upon which diameter is larger; using the selected maximum diameter to find the maximum diameter of this next segment; iteratively proceeding until the entire length of the vessel is examined; and selecting a stent in response to the diameters of the end proximal and distal segments.
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