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73 条记录 (耗时 0.029 秒)

    B7-H1, a novel immunoregulatory molecule
    33.
    发明授权
    B7-H1, a novel immunoregulatory molecule 有权
    B7-H1，一种新型的免疫调节分子

    公开(公告)号：US06803192B1

    公开(公告)日：2004-10-12

    申请号：US09451291

    申请日：1999-11-30

    申请人： Lieping Chen

    发明人： Lieping Chen

    IPC分类号： C12Q168

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2035/124

    摘要： The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides.

    摘要翻译： 本发明提供了可用于共刺激T细胞，编码它们的分离的核酸分子，含有核酸分子的载体和含有载体的细胞的新型多肽。 还包括制备和使用这些共刺激多肽的方法。

    Inhibition of tumor cell growth by administration of B7-transfected cells
    34.
    发明授权
    Inhibition of tumor cell growth by administration of B7-transfected cells 失效
    通过施用B7转染的细胞抑制肿瘤细胞生长

    公开(公告)号：US06183734B2

    公开(公告)日：2001-02-06

    申请号：US08402405

    申请日：1995-03-10

    申请人： Lieping Chen ,  Ingegerd Hellström ,  Karl Erik Hellström ,  Jeffrey A. Ledbetter ,  Peter S. Linsley

    发明人： Lieping Chen ,  Ingegerd Hellström ,  Karl Erik Hellström ,  Jeffrey A. Ledbetter ,  Peter S. Linsley

    IPC分类号： A01N6300

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  A61K48/00 ,  A61K2039/5156

    摘要： The present invention is directed to a method of inhibiting tumor cell growth. Tumor cells from a pateint are recombinantly engineered to express the B7 surface protein and these cells are then readminsistered to the pateint. The presence of the B7 molecule on the tumor cell surface stimulates a broad immunologic response against both the B7-transfected and non-transfected tumor cells and results in the immunologic killing of localized and metastatic tumor cells. B7 transfection of the tumor cells, or cell membranes, serves as a stimulant to engender a potent immunologic response against the surface antigens present on the tumor cells.

    摘要翻译： 本发明涉及一种抑制肿瘤细胞生长的方法。 来自pateint的肿瘤细胞被重组工程化以表达B7表面蛋白质，然后将这些细胞读取到pateint。 B7分子在肿瘤细胞表面的存在刺激对B7转染和未转染的肿瘤细胞的广泛的免疫应答，并导致局部和转移性肿瘤细胞的免疫学杀伤。 肿瘤细胞或细胞膜的B7转染作为刺激物，对肿瘤细胞上存在的表面抗原产生有效的免疫应答。

    B7-H1, a novel immunoregulatory molecule
    35.
    发明授权
    B7-H1, a novel immunoregulatory molecule 有权
    B7-H1，一种新型的免疫调节分子

    公开(公告)号：US09062112B2

    公开(公告)日：2015-06-23

    申请号：US12347492

    申请日：2008-12-31

    申请人： Lieping Chen

    发明人： Lieping Chen

    IPC分类号： C07K14/47 ,  C07K16/28 ,  A61K38/00 ,  A61K35/12

    CPC分类号： C07K16/2827 ,  A61K38/00 ,  A61K2035/124 ,  C07K14/47 ,  C07K2317/24 ,  C07K2317/76

    摘要： The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides.

    摘要翻译： 本发明提供了可用于共刺激T细胞，编码它们的分离的核酸分子，含有核酸分子的载体和含有载体的细胞的新型多肽。 还包括制备和使用这些共刺激多肽的方法。

    Detection and diagnosis of inflammatory disorders
    40.
    发明授权
    Detection and diagnosis of inflammatory disorders 有权
    炎性疾病的检测和诊断

    公开(公告)号：US07989173B2

    公开(公告)日：2011-08-02

    申请号：US12198014

    申请日：2008-08-25

    申请人： Lieping Chen

    发明人： Lieping Chen

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6875 ,  G01N2800/10

    摘要： Soluble H4 (sH4) levels have been discovered to correlate with the stage or severity of inflammatory disorders including autoimmune disorders. In particular, circulating levels of sH4 can be used as a diagnostic for determining the severity of an inflammatory disorder or the propensity for developing an inflammatory disorder. The severity of an inflammatory disorder can be determined by assaying the levels of sH4 in a subject and comparing the levels of sH4 to reference sH4 concentrations that correlate to specific stages of an inflammatory disorder. The therapeutic efficacy of treatments for inflammatory disorders can also be determined by comparing levels of sH4 before and during treatment. Methods and devices for measuring sH4 are also provided.

    摘要翻译： 已经发现可溶性H4（sH4）水平与包括自身免疫性疾病在内的炎性疾病的阶段或严重程度相关。 特别地，sH4的循环水平可以用作诊断炎症性疾病的严重性或发展为炎性疾病的倾向。 炎症性疾病的严重程度可以通过测定受试者中sH4的水平并将sH4与参与sH4浓度的水平进行比较来确定，该浓度与炎症性疾病的特定阶段相关。 治疗炎症性疾病的治疗效果也可以通过比较治疗前和治疗期间sH4的水平来确定。 还提供了用于测量sH4的方法和装置。