公开(公告)号：US20180217220A1

公开(公告)日：2018-08-02

申请号：US15928647

申请日：2018-03-22

Applicant: Case Western Reserve University

Inventor： Vikas Gulani ,  Mark A. Griswold ,  Nicole Seiberlich ,  Yong Chen ,  Bhairav B. Mehta ,  Simone Coppo

IPC: G01R33/565 ,  G01R33/56 ,  G01R33/561

CPC classification number: G01R33/56509 ,  G01R33/4818 ,  G01R33/50 ,  G01R33/5602 ,  G01R33/5607 ,  G01R33/5613 ,  G01R33/5659 ,  G01R33/5676

Abstract: A system and method for generating quantitative images of a subject using a nuclear magnetic resonance system. The method includes performing a navigator module to acquire navigator data, and performing an acquisition module during free breathing of the subject to acquire NMR data from the subject that contains one or more resonant species that simultaneously produce individual NMR signals in response to the acquisition module. The above steps are repeated to acquire data from a plurality of partitions across the volume. The navigator data is analyzed to determine if the NMR data meets a predetermined condition and if not, the above steps are repeated for at least an affected partition corresponding to NMR data that did not meet the predetermined condition. The NMR data is compared to a dictionary of signal evolutions to determine quantitative values for two or more parameters of the resonant species in the volume.

公开(公告)号：US11915670B2

公开(公告)日：2024-02-27

申请号：US18102332

申请日：2023-01-27

Applicant: Case Western Reserve University

Inventor： Mark A. Griswold ,  Erin Henninger ,  Jeff Mlakar ,  Henry Eastman ,  Robert Gotschall ,  Catherine Sue Shick ,  Galen Tingle

IPC: G09G5/14 ,  G06F3/01 ,  G06F3/0346 ,  G06T15/20 ,  G06T19/00 ,  G02B27/01 ,  H04L67/10

CPC classification number: G09G5/14 ,  G02B27/017 ,  G06F3/011 ,  G06F3/012 ,  G06F3/0346 ,  G06T15/20 ,  G06T19/00 ,  G06T19/006 ,  G02B2027/0134 ,  G06T2200/04 ,  G06T2200/24 ,  G06T2219/024 ,  G09G2354/00 ,  G09G2370/022 ,  H04L67/10

Abstract: Systems, methods, and media for displaying interactive augmented reality presentations are provided. In some embodiments, a system comprises: a plurality of head mounted displays, a first head mounted display comprising a transparent display; and at least one processor, wherein the at least one processor is programmed to: determine that a first physical location of a plurality of physical locations in a physical environment of the head mounted display is located closest to the head mounted display; receive first content comprising a first three dimensional model; receive second content comprising a second three dimensional model; present, using the transparent display, a first view of the first three dimensional model at a first time; and present, using the transparent display, a first view of the second three dimensional model at a second time subsequent to the first time based one or more instructions received from a server.

公开(公告)号：US11875509B2

公开(公告)日：2024-01-16

申请号：US17301492

申请日：2021-04-05

Applicant: Case Western Reserve University

Inventor： Mark A. Griswold ,  Dan Ma ,  Debra McGivney ,  Rasim Boyacioglu

IPC: G06T7/00 ,  G06T7/11 ,  G01R33/50 ,  G01R33/48 ,  G01R33/46 ,  G01R33/56 ,  G01R33/44

CPC classification number: G06T7/0014 ,  G01R33/445 ,  G01R33/4625 ,  G01R33/4824 ,  G01R33/50 ,  G01R33/5608 ,  G06T7/11 ,  G06T2207/10088 ,  G06T2207/30016

Abstract: A method for determining an undersampling error for a magnetic resonance fingerprinting (MRF) pulse sequence includes retrieving a plurality of sets of spatial response functions. Each set of spatial response functions is associated with a tissue type in a reference image and is based on a tissue mask of the reference image for each tissue type. A signal evolution for each tissue type may be generated based on, for example, the MRF pulse sequence, An undersampled image may be generated for each tissue type using the set of spatial response functions and the signal evolutions for the tissue type. At least one quantitative parameter may be determined by comparing an undersampled image series created from the undersampled images to an MRF dictionary. An undersampling error for the MRF pulse sequence may be generated by comparing a quantitative map (or maps) for the quantitative parameter (or parameters) and the reference image.

公开(公告)号：US11768264B2

公开(公告)日：2023-09-26

申请号：US17661736

申请日：2022-05-02

Applicant: Case Western Reserve University ,  University College Cardiff Consultants Limited

Inventor： Dan Ma ,  Mark A. Griswold ,  Derek Jones ,  Maryam Afzali ,  Lars Mueller

IPC: G01R33/50 ,  G01R33/563 ,  G01R33/56

CPC classification number: G01R33/50 ,  G01R33/5608 ,  G01R33/56341

Abstract: A method for multi-dimensional, relaxation-diffusion magnetic resonance fingerprinting (MRF) includes performing, using a magnetic resonance imaging (MRI) system, a pulse sequence that integrates free-waveform b-tensor diffusion encoding into a magnet resonance fingerprinting pulse sequence to perform a multi-dimensional, relaxation-diffusion encoding while acquiring MRF signal evolutions, processing, using a processor, the acquired MRF signal evolutions to determine at least one relaxation parameter and at least one diffusivity parameter, and generating, using the processor, a report including at least one of the at least one relaxation parameter and the at least diffusivity parameter.

公开(公告)号：US11580935B2

公开(公告)日：2023-02-14

申请号：US17180007

申请日：2021-02-19

Applicant: Case Western Reserve University

Inventor： Mark A. Griswold ,  Erin Henninger ,  Jeff Mlakar ,  Henry Eastman ,  Robert Gotschall ,  Catherine Sue Shick ,  Galen Tingle

IPC: G09G5/14 ,  G06F3/01 ,  G06F3/0346 ,  G06T15/20 ,  G06T19/00 ,  G02B27/01 ,  H04L67/10

Abstract: Systems, methods, and media for displaying interactive augmented reality presentations are provided. In some embodiments, a system comprises: a plurality of head mounted displays, a first head mounted display comprising a transparent display; and at least one processor, wherein the at least one processor is programmed to: determine that a first physical location of a plurality of physical locations in a physical environment of the head mounted display is located closest to the head mounted display; receive first content comprising a first three dimensional model; receive second content comprising a second three dimensional model; present, using the transparent display, a first view of the first three dimensional model at a first time; and present, using the transparent display, a first view of the second three dimensional model at a second time subsequent to the first time based one or more instructions received from a server.

公开(公告)号：US11442127B2

公开(公告)日：2022-09-13

申请号：US16603335

申请日：2018-04-06

Applicant: Case Western Reserve University

Inventor： Chris Flask ,  Christian Anderson ,  Xin Yu ,  Nicole Steinmetz ,  Mark A. Griswold ,  Susann Brady-Kalnay

IPC: G01R33/50 ,  A61B5/055 ,  G01R33/56 ,  G06T7/00 ,  G01R33/48

Abstract: The present disclosure provides a method of DDCE-MRF. The method can include: a) introducing two or more contrast agents to a region of interest (ROI) of a subject, the two or more contrast agents having different relaxivities; b) measuring a T1 relaxation time and a T2 relaxation time for locations within the ROI using magnetic resonance fingerprinting (MRF); c) determining, using equations that relate the different relaxivities, the T1 relaxation time, the T2 relaxation time, and concentrations of the two or more contrast agents, the concentrations of the two or more contrast agents for each of the locations within the ROI; and d) producing an image depicting the ROI based, at least in part, on the concentrations of the two or more contrast agents.

公开(公告)号：US11373392B2

公开(公告)日：2022-06-28

申请号：US16378166

申请日：2019-04-08

Applicant: Case Western Reserve University ,  SIEMENS HEALTHCARE GMBH

Inventor： Mathias Nittka ,  Gregor Korzdorfer ,  Peter Speier ,  Mark A. Griswold ,  Yun Jiang

IPC: G01R33/56 ,  G01R33/50 ,  G06T7/00 ,  G06V10/42

Abstract: A method for performing magnetic resonance fingerprinting includes acquiring a plurality of MR image datasets using at least two pulse sequence types, the plurality of MR image datasets representing signal evolutions for image elements in a region of interest, comparing the plurality of MR image datasets to a dictionary of signal evolutions to identify at least one parameter of the MR image datasets and generating a report indicating the at least one parameter of the MR image datasets.

公开(公告)号：US11372069B2

公开(公告)日：2022-06-28

申请号：US16686828

申请日：2019-11-18

Applicant: Case Western Reserve University

Inventor： Mark A. Griswold ,  Cameron McIntyre

IPC: G06K9/00 ,  G01R33/56 ,  G01R33/48 ,  G01R33/50

Abstract: A method for target identification for a deep brain stimulation procedure includes acquiring a set of magnetic resonance fingerprinting (MRF) data for a region of interest in a subject using a MRI system, comparing the set of MRF data to an MRF dictionary to determine at least one parameter for the MRF data for the region of interest, generating a quantitative map of the at least one parameter, segmenting a target area of the region of interest based on the MRF data, generating at least one trajectory for placement of at least one electrode in the target area of the region of interest based on the segmentation of the target area and displaying the quantitative map and the at least one trajectory on a display.

公开(公告)号：US11179052B2

公开(公告)日：2021-11-23

申请号：US16159888

申请日：2018-10-15

Applicant: Case Western Reserve University

Inventor： Mark A. Griswold ,  Anagha Deshmane ,  Jeffrey Sunshine

IPC: A61B5/026 ,  A61B5/055 ,  A61B5/00 ,  G01R33/563 ,  G01R33/44 ,  G01R33/48 ,  G01R33/565 ,  G01R33/56 ,  G01R33/561 ,  A61B1/00 ,  G01R1/00 ,  A61B17/00 ,  G06T1/00 ,  G01R33/50

Abstract: Example embodiments associated with characterizing a sample using NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals and a characterization logic that characterizes a tissue in the object as a result of comparing acquired signals to reference signals. Example embodiments facilitate distinguishing diseased tissue from healthy tissue based on tissue component fractions identified using the NMR fingerprinting.

公开(公告)号：US10859651B2

公开(公告)日：2020-12-08

申请号：US15945714

申请日：2018-04-04

Applicant: Case Western Reserve University

Inventor： Vikas Gulani ,  Mark A. Griswold ,  Alice Yang ,  Yun Jiang

IPC: G01R33/48 ,  G01R33/565 ,  G01R33/561 ,  G01R33/3875 ,  G01R33/385

Abstract: A system and method for performing magnetic resonance fingerprinting (MRF) is provided that includes performing a pulse sequence that is sensitive to field inhomogeneities to acquire a series of signal evolutions form a region of interest (ROI) of the subject to form MRF data. The method also includes varying field inhomogeneities across the ROI to acquire the series of signal evolutions, comparing the MRF data with an MRF dictionary to determine at least one tissue property of the subject in the ROI, and producing at least one map of the at least one tissue property.