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    System and method for proton density mapping and receiver bias correction using magnetic resonance fingerprinting (MRF)
    2.
    发明授权
    System and method for proton density mapping and receiver bias correction using magnetic resonance fingerprinting (MRF) 有权

    公开(公告)号：US11079448B2

    公开(公告)日：2021-08-03

    申请号：US16461549

    申请日：2017-11-15

    Applicant: Case Western Reserve University

    Inventor： Mark A. Griswold ,  Anagha Deshmane

    IPC: G01R33/24 ,  A61B5/00 ,  A61B5/055 ,  G01R33/48 ,  G01R33/50 ,  G01R33/565

    Abstract: A system and method is provided for correcting receiver bias during quantitative proton density mapping with magnetic resonance fingerprinting (MRF). The method comprises acquiring MRF data from a region of interest in a subject by performing a pulse sequence using a series of varied sequence blocks to elicit a series of signal evolutions. The method further comprises comparing the MRF data to a MRF dictionary to simultaneously map proton density and another tissue property from the region of interest, the proton density map having a proton density signal and a receiver sensitivity profile signal. The method also includes quantifying the proton density signal and the receiver sensitivity profile signal using parameters provided by the proton density map and the tissue property map, and generating a quantitative map from the region of interest based on the proton density signal.

    Nuclear magnetic resonance (NMR) fingerprinting tissue classification and image segmentation
    3.
    发明授权
    Nuclear magnetic resonance (NMR) fingerprinting tissue classification and image segmentation 有权

    公开(公告)号：US10527698B2

    公开(公告)日：2020-01-07

    申请号：US16053873

    申请日：2018-08-03

    Applicant: Case Western Reserve University

    Inventor： Mark A. Griswold ,  Yun Jiang ,  Dan Ma ,  Anagha Deshmane ,  Chaitra Badve ,  Vikas Gulani ,  Jeffrey L. Sunshine

    IPC: G06K9/00 ,  G01R33/56 ,  G01R33/48 ,  G01R33/50

    Abstract: Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals, and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals. The NMR signal evolution may be assigned to a cluster based on the characterization of the resonant species. Cluster overlay maps may be produced simultaneously based, at least in part, on the clustering. The clusters may be associated with different tissue types.

    Nuclear Magnetic Resonance (NMR) Fingerprinting Tissue Classification And Image Segmentation
    4.
    发明申请
    Nuclear Magnetic Resonance (NMR) Fingerprinting Tissue Classification And Image Segmentation 审中-公开
    核磁共振（NMR）指纹组织分类和图像分割

    公开(公告)号：US20150301141A1

    公开(公告)日：2015-10-22

    申请号：US14257081

    申请日：2014-04-21

    Applicant: Case Western Reserve University

    Inventor： Mark Griswold ,  Yun Jiang ,  Dan Ma ,  Anagha Deshmane ,  Chaitra Badve ,  Vikas Gulani

    IPC: G01R33/56 ,  G06K9/52 ,  G06T7/00 ,  G01R33/36 ,  G01R33/48

    CPC classification number: G01R33/5608 ,  G01R33/4828 ,  G01R33/50

    Abstract: Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals, and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals. The NMR signal evolution may be assigned to a cluster based on the characterization of the resonant species. Cluster overlay maps may be produced simultaneously based, at least in part, on the clustering. The clusters may be associated with different tissue types.

    Abstract translation: 描述了与NMR指纹图谱相关联的装置，方法和其它实施例。 一个例子的NMR装置包括NMR逻辑，其重复和可变地采样与物体相关联的（k，t，E）空间，以获得与（k，t，E）空间中的不同点相关联的一组NMR信号。 t和/或E以非常数方式变化进行采样。 NMR装置还可以包括从NMR信号产生NMR信号演化的信号逻辑，以及作为将获取的信号与参考信号进行比较的结果来表征物体中的共振物种的表征逻辑。 基于共振物种的表征，可以将NMR信号进化分配给簇。 可以至少部分地基于聚类来同时地产生群集覆盖图。 簇可以与不同的组织类型相关联。

    System and Method for Proton Density Mapping and Receiver Bias Correction Using Magnetic Resonance Fingerprinting (MRF)
    5.
    发明申请
    System and Method for Proton Density Mapping and Receiver Bias Correction Using Magnetic Resonance Fingerprinting (MRF) 审中-公开

    公开(公告)号：US20190353718A1

    公开(公告)日：2019-11-21

    申请号：US16461549

    申请日：2017-11-15

    Applicant: Case Western Reserve University

    Inventor： Mark A. Griswold ,  Anagha Deshmane

    IPC: G01R33/24 ,  G01R33/50 ,  G01R33/48 ,  G01R33/565 ,  A61B5/055 ,  A61B5/00

    Abstract: A system and method is provided for correcting receiver bias during quantitative proton density mapping with magnetic resonance fingerprinting (MRF). The method comprises acquiring MRF data from a region of interest in a subject by performing a pulse sequence using a series of varied sequence blocks to elicit a series of signal evolutions. The method further comprises comparing the MRF data to a MRF dictionary to simultaneously map proton density and another tissue property from the region of interest, the proton density map having a proton density signal and a receiver sensitivity profile signal. The method also includes quantifying the proton density signal and the receiver sensitivity profile signal using parameters provided by the proton density map and the tissue property map, and generating a quantitative map from the region of interest based on the proton density signal.

    Nuclear magnetic resonance (NMR) fingerprinting tissue classification and image segmentation
    6.
    发明授权
    Nuclear magnetic resonance (NMR) fingerprinting tissue classification and image segmentation 有权

    公开(公告)号：US10261154B2

    公开(公告)日：2019-04-16

    申请号：US14257081

    申请日：2014-04-21

    Applicant: Case Western Reserve University

    Inventor： Mark Griswold ,  Yun Jiang ,  Dan Ma ,  Anagha Deshmane ,  Chaitra Badve ,  Vikas Gulani ,  Jeffrey L Sunshine

    IPC: G06K9/00 ,  G01R33/56 ,  G01R33/48 ,  G01R33/50

    Abstract: Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals, and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals. The NMR signal evolution may be assigned to a cluster based on the characterization of the resonant species. Cluster overlay maps may be produced simultaneously based, at least in part, on the clustering. The clusters may be associated with different tissue types.

    Nuclear Magnetic Resonance (NMR) Fingerprinting Tissue Classification and Image Segmentation
    9.
    发明申请
    Nuclear Magnetic Resonance (NMR) Fingerprinting Tissue Classification and Image Segmentation 审中-公开

    公开(公告)号：US20180372825A1

    公开(公告)日：2018-12-27

    申请号：US16053873

    申请日：2018-08-03

    Applicant: Case Western Reserve University

    Inventor： Mark A. Griswold ,  Yun Jiang ,  Dan Ma ,  Anagha Deshmane ,  Chaitra Badve ,  Vikas Gulani ,  Jeffrey L. Sunshine

    IPC: G01R33/56 ,  G01R33/50 ,  G01R33/48

    Abstract: Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals, and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals. The NMR signal evolution may be assigned to a cluster based on the characterization of the resonant species. Cluster overlay maps may be produced simultaneously based, at least in part, on the clustering. The clusters may be associated with different tissue types.

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