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公开(公告)号：US20220349971A1
公开(公告)日：2022-11-03
申请号：US17661736
申请日：2022-05-02
发明人： Dan Ma , Mark A. Griswold , Derek Jones , Maryam Afzall , Lars Mueller
IPC分类号： G01R33/50 , G01R33/56 , G01R33/563
摘要： A method for multi-dimensional, relaxation-diffusion magnetic resonance fingerprinting (MRF) includes performing, using a magnetic resonance imaging (MRI) system, a pulse sequence that integrates free-waveform b-tensor diffusion encoding into a magnet resonance fingerprinting pulse sequence to perform a multi-dimensional, relaxation-diffusion encoding while acquiring MRF signal evolutions, processing, using a processor, the acquired MRF signal evolutions to determine at least one relaxation parameter and at least one diffusivity parameter, and generating, using the processor, a report including at least one of the at least one relaxation parameter and the at least diffusivity parameter.
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公开(公告)号：US10898089B2
公开(公告)日：2021-01-26
申请号：US14690511
申请日：2015-04-20
发明人： Vikas Gulani , Mark Griswold , Dan Ma , Alice Yang
IPC分类号： G01R33/44 , A61B5/026 , A61B5/055 , A61B5/00 , G01R33/563 , G01R33/48 , G01R33/565 , G01R33/56 , G01R33/561 , A61B1/00 , G01R1/00 , A61B17/00 , G06T1/00 , G01R33/50
摘要： Example apparatus and methods improve magnetic resonance fingerprinting (MRF) by performing MRF with optimized spatial encoding, parallel imaging, and utilization of field inhomogeneities. Multi-echo radial trajectories and spiral trajectories may acquire data according to sampling schemes based on models of charge distribution on a sphere. Non-uniform sampling schemes may account for differences in detector coil performance. Field inhomogeneities provide spatial information that enhances the spatial separation of an MRF signal and facilitates unaliasing pixels. The field inhomogeneity may be manipulated. An MRF pulse sequence may include frequency selective RF pulses that are determined by the field inhomogeneities. Inhomogeneities combined with selective RF pulses result in higher acquisition efficiency.
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公开(公告)号：US10416259B2
公开(公告)日：2019-09-17
申请号：US14270389
申请日：2014-05-06
发明人： Mark Griswold , Nicole Seiberlich , Dan Ma , Vikas Gulani
IPC分类号： G01R33/54 , G01R33/56 , G01R33/48 , G01R33/50 , G01R33/563
摘要： Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, a matching logic configured to compare a signal evolution to a known, simulated or predicted signal evolution, and a characterization logic configured to characterize a resonant species in the object as a result of the signal evolution comparisons.
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公开(公告)号：US10281547B2
公开(公告)日：2019-05-07
申请号：US14257207
申请日：2014-04-21
发明人： Mark Griswold , Vikas Gulani , Dan Ma , Yun Jiang , Katherine Wright
IPC分类号： G01R33/56 , G01R33/48 , G01R33/36 , G06T7/00 , G01R33/563
摘要： Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. Sampling is performed in response to a diffusion-weighted double-echo pulse sequence. Sampling acquires transient-state signals of the double-echo sequence. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals, and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals.
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公开(公告)号：US10241174B2
公开(公告)日：2019-03-26
申请号：US14244001
申请日：2014-04-03
发明人： Mark Griswold , Nicole Seiberlich , Dan Ma , Vikas Gulani
IPC分类号： G01R33/54 , G01R33/56 , G01R33/48 , G01R33/50 , G01R33/563
摘要： Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, a matching logic configured to compare a signal evolution to a known, simulated or predicted signal evolution, and a characterization logic configured to characterize a resonant species in the object as a result of the signal evolution comparisons.
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公开(公告)号：US20150070012A1
公开(公告)日：2015-03-12
申请号：US14024915
申请日：2013-09-12
发明人： Mark Griswold , Yun Jiang , Dan Ma
CPC分类号： G01R33/283 , G01R33/4828 , G01R33/56
摘要： Apparatus, methods, and other embodiments associated with optimizing sounds produced during nuclear magnetic resonance (NMR) fingerprinting are described. One example NMR apparatus includes an NMR logic to repetitively and variably sample a (k, t, E) space associated with a patient to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The parameters are varied in different acquisition blocks to facilitate matching sounds produced in response to the acquisition blocks to a desired set of sounds. The desired set of sounds may be a musical piece.
摘要翻译： 描述了与优化在核磁共振（NMR）指纹中产生的声音有关的装置，方法和其它实施例。 一个例子的NMR装置包括NMR逻辑，以重复和可变地采样与患者相关联的（k，t，E）空间以获得一组NMR信号。 一组NMR信号的成员与（k，t，E）空间中的不同点相关联。 t和/或E以非常数方式变化进行采样。 变化的参数可以包括翻转角，回波时间，RF幅度和其他参数。 这些参数在不同的采集块中是变化的，以便将响应于采集块产生的声音匹配到期望的一组声音。 所需的一组声音可能是一个音乐作品。
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公开(公告)号：US11875509B2
公开(公告)日：2024-01-16
申请号：US17301492
申请日：2021-04-05
发明人： Mark A. Griswold , Dan Ma , Debra McGivney , Rasim Boyacioglu
CPC分类号： G06T7/0014 , G01R33/445 , G01R33/4625 , G01R33/4824 , G01R33/50 , G01R33/5608 , G06T7/11 , G06T2207/10088 , G06T2207/30016
摘要： A method for determining an undersampling error for a magnetic resonance fingerprinting (MRF) pulse sequence includes retrieving a plurality of sets of spatial response functions. Each set of spatial response functions is associated with a tissue type in a reference image and is based on a tissue mask of the reference image for each tissue type. A signal evolution for each tissue type may be generated based on, for example, the MRF pulse sequence, An undersampled image may be generated for each tissue type using the set of spatial response functions and the signal evolutions for the tissue type. At least one quantitative parameter may be determined by comparing an undersampled image series created from the undersampled images to an MRF dictionary. An undersampling error for the MRF pulse sequence may be generated by comparing a quantitative map (or maps) for the quantitative parameter (or parameters) and the reference image.
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公开(公告)号：US11768264B2
公开(公告)日：2023-09-26
申请号：US17661736
申请日：2022-05-02
发明人： Dan Ma , Mark A. Griswold , Derek Jones , Maryam Afzali , Lars Mueller
IPC分类号： G01R33/50 , G01R33/563 , G01R33/56
CPC分类号： G01R33/50 , G01R33/5608 , G01R33/56341
摘要： A method for multi-dimensional, relaxation-diffusion magnetic resonance fingerprinting (MRF) includes performing, using a magnetic resonance imaging (MRI) system, a pulse sequence that integrates free-waveform b-tensor diffusion encoding into a magnet resonance fingerprinting pulse sequence to perform a multi-dimensional, relaxation-diffusion encoding while acquiring MRF signal evolutions, processing, using a processor, the acquired MRF signal evolutions to determine at least one relaxation parameter and at least one diffusivity parameter, and generating, using the processor, a report including at least one of the at least one relaxation parameter and the at least diffusivity parameter.
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公开(公告)号：US10241178B2
公开(公告)日：2019-03-26
申请号：US15169166
申请日：2016-05-31
发明人： Susann Brady-Kalnay , Vikas Gulani , Mark Griswold , Chris Flask , Lan Lu , Ying Gao , Yun Jiang , Dan Ma
IPC分类号： G01V3/00 , G01R33/561 , G01R33/50 , G01R33/565
摘要： A system and method is provided for operating a high-field magnetic resonance (MR) system includes performing a series of data acquisition modules without respiratory gating. Each data acquisition module is formed of a steady-state free precession pulse sequence. Performing the series of data acquisition modules includes varying at least one of an amplitude of an excitation pulse or a repetition time of the steady-state free precession pulse sequence between adjacent data acquisition modules in the series of data acquisition modules to acquire a series of MR data with random or pseudo-random imaging acquisition parameters. The series of MR data is compared to a dictionary of signal evolution profiles to determine a match between the series of MR data with at least one signal evolution profile in the dictionary indicating at least one quantitative parameter in the subject.
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10.发明申请公开(公告)号：US20180372825A1
公开(公告)日：2018-12-27
申请号：US16053873
申请日：2018-08-03
发明人： Mark A. Griswold , Yun Jiang , Dan Ma , Anagha Deshmane , Chaitra Badve , Vikas Gulani , Jeffrey L. Sunshine
摘要： Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals, and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals. The NMR signal evolution may be assigned to a cluster based on the characterization of the resonant species. Cluster overlay maps may be produced simultaneously based, at least in part, on the clustering. The clusters may be associated with different tissue types.
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