公开(公告)号：US20240385268A1

公开(公告)日：2024-11-21

申请号：US18665093

申请日：2024-05-15

Applicant: Case Western Reserve University ,  Vanderbilt University

Inventor： Sai Abitha Srinivas ,  William A. Grissom ,  Mark A. Griswold

IPC: G01R33/483 ,  G01R33/3415 ,  G01R33/56 ,  G01R33/58

Abstract: A system for RF based frequency encoding utilizing a Bloch-Siegert shift, includes a controller, an RF encoding system, and an injection transformer simultaneous transmit and receive filter. The controller generates RF excitation pulses, RF based frequency encoding pulses, and a cancellation signal. The RF encoding system includes one or more RF coils configured to transmit the RF excitation pulses and RF based frequency encoding pulses, and to receive an MR signal from the subject where the MR signal includes a leakage signal induced by the RF based frequency encoding pulses. The injection transformer simultaneous transmit and receive filter is in signal communication with the controller and the RF encoding system. The injection transformer simultaneous transmit receive filter is configured to receive the cancellation signal, the MR signal including the leakage signal, and to cancel the leakage signal from the received MR signal to generate a filtered MR signal.

公开(公告)号：US11841413B2

公开(公告)日：2023-12-12

申请号：US17758138

申请日：2020-12-30

Applicant: Case Western Reserve University ,  Vanderbilt University

Inventor： Mark A. Griswold ,  William A. Grissom

IPC: G01R33/565 ,  G01R33/483

CPC classification number: G01R33/56554 ,  G01R33/4831 ,  G01R33/4833

Abstract: The present application provides a system and method for using a nuclear magnetic resonance (NMR) system. The method includes performing a pulse sequence using the NMR system that spatially encodes NMR signal evolutions to be acquired from a subject using an aggregated radio-frequency (B1) field incoherence and resolving the NMR signal evolutions acquired from the subject using at least one of a dictionary of known magnetic resonance fingerprinting (MRF) signal evolutions to determine matches in the NMR signal evolutions to the known MRF signal evolutions or an optimization process. The method also includes generating at least two spatially-resolved measurements indicating quantitative tissue parameters of the subject in at least two locations.

公开(公告)号：US11555874B2

公开(公告)日：2023-01-17

申请号：US16681454

申请日：2019-11-12

Applicant: Case Western Reserve University

Inventor： Andrew Dupuis ,  Nicole Seiberlich ,  Dominique Franson ,  Mark A. Griswold

IPC: G01R33/28 ,  G01R33/56 ,  G06T11/00 ,  G06F3/04815 ,  G06F3/04845 ,  A61B34/20 ,  A61B5/00 ,  A61B5/055 ,  G06F3/01

Abstract: A system for displaying and interacting with magnetic resonance imaging (MRI) data acquired using an MRI system includes an image reconstruction module configured to receive the MRI data and to reconstruct a plurality of images using the MRI data, an image rendering module coupled to the image reconstruction module and configured to generate at least one multidimensional image based on the plurality of images and a user interface device coupled to the image rendering module and located proximate to a workstation of the MRI system. The user interface device is configured to display the at least one multidimensional image in real-time and to facilitate interaction by a user with the multidimensional image in a virtual reality or augmented reality environment.

公开(公告)号：US20210312887A1

公开(公告)日：2021-10-07

申请号：US17304371

申请日：2021-06-18

Applicant: Case Western Reserve University

Inventor： Mark A. Griswold ,  Henry Eastman ,  Robert Gotschall

IPC: G09G5/14 ,  G06F3/01 ,  G06F3/0346 ,  G06T15/20 ,  G06T19/00 ,  G02B27/01

Abstract: Systems, methods, and media for displaying interactive augmented reality presentations are provided. In some embodiments, a system comprises: a head mounted display comprising: a transparent display; a plurality of sensors; and at least one processor, wherein the at least one processor is programmed to: select a content display location of a plurality of predetermined content display locations to use to present content based at least in part on a location of the head mounted display within a current physical environment; and cause content to be presented by the head mounted display anchored at the selected content display location.

公开(公告)号：US11131733B2

公开(公告)日：2021-09-28

申请号：US16859175

申请日：2020-04-27

Applicant: Case Western Reserve University ,  Siemens Healthcare GmbH

Inventor： Yun Jiang ,  Mark A. Griswold ,  Gregor Korzdorfer ,  Mathias Nittka

IPC: G01R33/50 ,  G01R33/56 ,  A61B5/055 ,  G01R33/48 ,  G01R33/561 ,  G01R33/54

Abstract: A system and method is provided for acquisition of magnetic resonance fingerprinting (“MRF”) data that includes determining a non-locally sequential sampling pattern for a Cartesian grid of k-space, performing a series of sequence blocks using acquisition parameters that vary between sequence blocks to acquire MRF data from a subject using the Cartesian grid of k-space and the determined non-locally sequential sampling pattern, assembling the MRF data into a series of signal evolutions, comparing the series of signal evolutions to a dictionary of known signal evolutions to determine tissue properties of the subject, and generating a report indicating the tissue properties of the subject.

公开(公告)号：US11079448B2

公开(公告)日：2021-08-03

申请号：US16461549

申请日：2017-11-15

Applicant: Case Western Reserve University

Inventor： Mark A. Griswold ,  Anagha Deshmane

IPC: G01R33/24 ,  A61B5/00 ,  A61B5/055 ,  G01R33/48 ,  G01R33/50 ,  G01R33/565

Abstract: A system and method is provided for correcting receiver bias during quantitative proton density mapping with magnetic resonance fingerprinting (MRF). The method comprises acquiring MRF data from a region of interest in a subject by performing a pulse sequence using a series of varied sequence blocks to elicit a series of signal evolutions. The method further comprises comparing the MRF data to a MRF dictionary to simultaneously map proton density and another tissue property from the region of interest, the proton density map having a proton density signal and a receiver sensitivity profile signal. The method also includes quantifying the proton density signal and the receiver sensitivity profile signal using parameters provided by the proton density map and the tissue property map, and generating a quantitative map from the region of interest based on the proton density signal.

公开(公告)号：US10761171B2

公开(公告)日：2020-09-01

申请号：US15928647

申请日：2018-03-22

Applicant: Case Western Reserve University

Inventor： Vikas Gulani ,  Nicole Seiberlich ,  Mark A. Griswold ,  Yong Chen ,  Bhairav B. Mehta ,  Simone Coppo

IPC: G01R33/565 ,  G01R33/561 ,  G01R33/56 ,  G01R33/50 ,  G01R33/567 ,  G01R33/48

Abstract: A system and method for generating quantitative images of a subject using a nuclear magnetic resonance system. The method includes performing a navigator module to acquire navigator data, and performing an acquisition module during free breathing of the subject to acquire NMR data from the subject that contains one or more resonant species that simultaneously produce individual NMR signals in response to the acquisition module. The above steps are repeated to acquire data from a plurality of partitions across the volume. The navigator data is analyzed to determine if the NMR data meets a predetermined condition and if not, the above steps are repeated for at least an affected partition corresponding to NMR data that did not meet the predetermined condition. The NMR data is compared to a dictionary of signal evolutions to determine quantitative values for two or more parameters of the resonant species in the volume.

公开(公告)号：US10598747B2

公开(公告)日：2020-03-24

申请号：US15946922

申请日：2018-04-06

Applicant: Case Western Reserve University ,  The General Hospital Corporation

Inventor： Vikas Gulani ,  Mark A. Griswold ,  Alice Yang ,  Yun Jiang ,  Kawin Setsompop

IPC: G01R33/483 ,  G01R33/56 ,  G01R33/54 ,  G01R33/24 ,  G01R33/561 ,  G01R33/50

Abstract: A magnetic resonance fingerprinting (“MRF”) framework that implements simultaneous multislice acquisition techniques with a Hadamard RF-encoding to simultaneously acquire magnetic resonance data from multiple slices simultaneously is described. As one non-limiting example, magnetic resonance data can be simultaneously acquired from four different slices. In other embodiments, however, the Hadamard encoding can be condensed into one or two acquisitions, rather than four.

公开(公告)号：US20200041595A1

公开(公告)日：2020-02-06

申请号：US16603335

申请日：2018-04-06

Applicant: Case Western Reserve University

Inventor： Chris Flask ,  Christian Anderson ,  Xin Yu ,  Nicole Steinmetz ,  Mark A. Griswold ,  Susann Brady-Kalnay

IPC: G01R33/50 ,  A61B5/055 ,  G01R33/56 ,  G06T7/00 ,  G01R33/48

Abstract: The present disclosure provides a method of DDCE-MRF. The method can include: a) introducing two or more contrast agents to a region of interest (ROI) of a subject, the two or more contrast agents having different relaxivities; b) measuring a T1 relaxation time and a T2 relaxation time for locations within the ROI using magnetic resonance fingerprinting (MRF); c) determining, using equations that relate the different relaxivities, the T1 relaxation time, the T2 relaxation time, and concentrations of the two or more contrast agents, the concentrations of the two or more contrast agents for each of the locations within the ROI; and d) producing an image depicting the ROI based, at least in part, on the concentrations of the two or more contrast agents.

公开(公告)号：US20190353732A1

公开(公告)日：2019-11-21

申请号：US16416666

申请日：2019-05-20

Applicant: Case Western Reserve University

Inventor： Debra McGivney ,  Mark A. Griswold

IPC: G01R33/50 ,  G01R33/54 ,  G01R33/56

Abstract: A method for magnetic resonance fingerprinting (MRF), including accessing MRF data and a dictionary of signal evolutions. A plurality of regions-of-interest (ROIs) are selected in the MRF data. A first series of tissue parameter estimates is generated from the MRF data in the ROIs using the dictionary and a multicomponent Bayesian framework. From the first series of tissue parameter estimates, probability distributions are computed for different tissue types. The method further includes creating a reduced dictionary by removing entries from the dictionary having tissue parameter values not contained within the computed probability distributions. A second series of tissue parameter estimates is generated from the MRF data using the reduced dictionary and a multicomponent Bayesian framework. The method also includes generating a tissue probability map for each different tissue type from the second series of tissue parameter estimates.