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公开(公告)号：US11346982B2
公开(公告)日：2022-05-31
申请号：US17038266
申请日：2020-09-30
Applicant: Alcon Inc.
Inventor： Daqing Wu , Junhao Ge , Steve Yun Zhang , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
IPC: G02B1/04 , C08L83/04 , C08F230/08 , B29D11/00
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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公开(公告)号：US20210284778A1
公开(公告)日：2021-09-16
申请号：US17197460
申请日：2021-03-10
Applicant: Alcon Inc.
Inventor： Yuan Chang , Junhao Ge , Steve Yun Zhang , Weihong Lang
IPC: C08F283/12 , G02B1/04 , C08G77/06 , C08G77/442 , C08L83/12 , C09K9/02
Abstract: The invention provides a class of photochromic polydiorganosiloxane vinylic crosslinkers. Each of the photochromic polydiorganosiloxane vinylic crosslinkers of the invention comprise (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and photochromic siloxane unit having one methyl substituent and one organic substituent having a photochromic moiety that capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light; (2) two terminal ethylenically-unsaturated groups. The invention also provides a soft photochromic contact lens, especially a photochromic silicone hydrogel contact lens, which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers. The invention further provides a method of producing a photochromic contact lens from a polymerizable composition comprising at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers.
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公开(公告)号：US12194699B2
公开(公告)日：2025-01-14
申请号：US17710199
申请日：2022-03-31
Applicant: Alcon Inc.
Inventor： Zahra Bassampour , Chandana Kolluru , Steve Yun Zhang , Junhao Ge , Yang Zheng , Cornelius Daniel Niculas , David Andrew Icenogle , Jing Cheng , Yuan Chang , Augustine Twum Kumi , Michelle Plavnik
Abstract: The invention relates to a method for producing embedded hydrogel contact lenses involving a set of 3-mold halves consisting essentially of: one female lens mold half having a molding surface defining the anterior surface of a contact lens; one male lens mold half having a molding surface defining the posterior surface of the contact lens; and an insert mold half having a molding surface defining one of the front and back surfaces of an insert. One of the lens mold halves is used twice: first with the insert mold half for molding an insert during first curing process and then with the other lens mold half for molding an embedded hydrogel contact lens with the molded insert embedded partially or fully therein during second curing process. The invention also relates to embedded hydrogel contact lenses produced from a method of the invention.
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公开(公告)号：US11975499B2
公开(公告)日：2024-05-07
申请号：US17518432
申请日：2021-11-03
Applicant: Alcon Inc.
Inventor： Yuan Chang , Junhao Ge , Steve Yun Zhang
CPC classification number: B29D11/00048 , C08F2/48 , G02B1/043
Abstract: Described herein is a method for producing photochromic contact lenses, in particular, photochromic silicone hydrogel contact lenses. The method comprises a step of cast molding of a lens-forming composition including a vinylic monomer having a primary amino or thiolactone group to form an unprocessed contact lens having the polymer matrix of which have pendant primary amino or thiolactone groups, a step of one-pot multistep reactions based on thiolactone chemistry (aminolysis and thiol-induced graft polymerization of a photochromic vinylic monomer to the polymer matrix) which are carried out only in its central region which is circular and concentric with the central axis of the unprocessed contact lens. The obtained photochromic contact lens has a central pupillary region that only can undergo a reversible color change upon exposure to UV/HEVL-radiation.
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公开(公告)号：US11931454B2
公开(公告)日：2024-03-19
申请号：US17024268
申请日：2020-09-17
Applicant: Alcon Inc.
Inventor： Junhao Ge , Steve Yun Zhang , Daqing Wu , Jing Cheng
CPC classification number: A61K9/0051 , A61K9/06 , A61K45/06 , A61K47/32 , A61K47/36
Abstract: The invention is generally related to a soft hydrogel ocular insert that is composed of at least one hydrogel material in fully hydrated state and can be comfortable for wearing. The hydrogel material comprises polymer chains, which are derived from at least one arylborono-containing hydrophilic copolymer and at least one mucoadhesive polymer, and cyclic boronic ester crosslinks for crosslinking those mucoadhesive polymer chains and arylborono-containing hydrophilic copolymer chains to form a 3-dimensional polymer network. Those cyclic boronic ester crosslinks can be hydrolyzed slowly in the tear of the eyes of a patient, resulting in the disintegration (dissolution) of the 3-dimensional polymer network and thereby providing mucoadhesisve polymers and optionally drugs impregnated in the hydrogel ocular insert in a controlled manner.
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Patent Agency Ranking
公开(公告)号：US11833771B2
公开(公告)日：2023-12-05
申请号：US17710248
申请日：2022-03-31
Applicant: Alcon Inc.
Inventor： Yuan Chang , Junhao Ge , Steve Yun Zhang , Michelle Plavnik , Yang Zheng , Jing Cheng , Augustine Twum Kumi
CPC classification number: B29D11/00134 , C08L83/14 , G02C7/04 , G02C7/102 , B29K2083/00 , C08L2203/02 , C08L2205/03
Abstract: Described herein is a method for producing a contact lens comprising a central photochromic zone that has a diameter of about 13 mm or less and is concentric with the central axis of the contact lens. The method comprises: applying, in the center of the molding surface of a male mold half, a drop (having a volume of about 5 μL or less) of a first polymerizable fluid composition containing at least one photochromic compound and a relatively-high molecular weight polysiloxane vinylic crosslinker for increasing the viscosity and adhesion on the molding surface of the male mold half; dosing a second polymerizable fluid composition in a female mold hald; closing the female mold hald with the male mold half with the drop thereon to form a molding assembly; and curing the second polymerizable fluid composition and the drop of the first polymerizable fluid composition in the molding assembly.
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公开(公告)号：US20220339895A1
公开(公告)日：2022-10-27
申请号：US17710248
申请日：2022-03-31
Applicant: Alcon Inc.
Inventor： Yuan Chang , Junhao Ge , Steve Yun Zhang , Michelle Plavnik , Yang Zheng , Jing Cheng , Augustine Twum Kumi
Abstract: Described herein is a method for producing a contact lens comprising a central photochromic zone that has a diameter of about 13 mm or less and is concentric with the central axis of the contact lens. The method comprises: applying, in the center of the molding surface of a male mold half, a drop (having a volume of about 5 μL or less) of a first polymerizable fluid composition containing at least one photochromic compound and a relatively-high molecular weight polysiloxane vinylic crosslinker for increasing the viscosity and adhesion on the molding surface of the male mold half; dosing a second polymerizable fluid composition in a female mold hald; closing the female mold hald with the male mold half with the drop thereon to form a molding assembly; and curing the second polymerizable fluid composition and the drop of the first polymerizable fluid composition in the molding assembly.
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公开(公告)号：US20220324187A1
公开(公告)日：2022-10-13
申请号：US17710199
申请日：2022-03-31
Applicant: Alcon Inc.
Inventor： Zahra Bassampour , Chandana Kolluru , Steve Yun Zhang , Junhao Ge , Yang Zheng , Cornelius Daniel Niculas , David Andrew Icenogle , Jing Cheng , Yuan Chang , Augustine Twum Kumi , Michelle Plavnik
Abstract: The invention relates to a method for producing embedded hydrogel contact lenses involving a set of 3-mold halves consisting essentially of: one female lens mold half having a molding surface defining the anterior surface of a contact lens; one male lens mold half having a molding surface defining the posterior surface of the contact lens; and an insert mold half having a molding surface defining one of the front and back surfaces of an insert. One of the lens mold halves is used twice: first with the insert mold half for molding an insert during first curing process and then with the other lens mold half for molding an embedded hydrogel contact lens with the molded insert embedded partially or fully therein during second curing process. The invention also relates to embedded hydrogel contact lenses produced from a method of the invention.
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公开(公告)号：US11254075B2
公开(公告)日：2022-02-22
申请号：US16429853
申请日：2019-06-03
Applicant: Alcon Inc.
Inventor： Richard Charles Breitkopf , Daqing Wu , Junhao Ge , Steve Yun Zhang
Abstract: The invention provides a contact lens manufacturing method comprising a process for removing unprocessed molded silicone hydrogel contact lenses from mold halves in a relatively efficient and consistent manner. A method of the invention comprises the combination of using a hydrophilic (meth)acrylamido monomer as one of major polymerizable components in a lens formulation for cast-molding of contact lenses, adding a post-curing treatment step which involves heating molds with molded lenses therewithin in an oven at a post-curing temperature higher than the curing temperature and under nitrogen gas flow at a higher flow rate, and using ultrasonic vibration energy for delensing. This method of the invention can be easily implemented in a production environment for enhancing the production yield.
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公开(公告)号：US20210077385A1
公开(公告)日：2021-03-18
申请号：US17024268
申请日：2020-09-17
Applicant: Alcon Inc.
Inventor： Junhao Ge , Steve Yun Zhang , Daqing Wu , Jing Cheng
Abstract: The invention is generally related to a soft hydrogel ocular insert that is composed of at least one hydrogel material in fully hydrated state and can be comfortable for wearing. The hydrogel material comprises polymer chains, which are derived from at least one arylborono-containing hydrophilic copolymer and at least one mucoadhesive polymer, and cyclic boronic ester crosslinks for crosslinking those mucoadhesive polymer chains and arylborono-containing hydrophilic copolymer chains to form a 3-dimensional polymer network. Those cyclic boronic ester crosslinks can be hydrolyzed slowly in the tear of the eyes of a patient, resulting in the disintegration (dissolution) of the 3-dimensional polymer network and thereby providing mucoadhesisve polymers and optionally drugs impregnated in the hydrogel ocular insert in a controlled manner.
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