公开(公告)号：US20050203599A1

公开(公告)日：2005-09-15

申请号：US10799271

申请日：2004-03-12

Applicant: Robert Garabedian ,  Michael Wallace

Inventor： Robert Garabedian ,  Michael Wallace

IPC: A61N1/04 ,  A61N1/05 ,  A61N1/34 ,  A61N1/36

CPC classification number: A61N1/36071 ,  A61N1/0551 ,  A61N1/36017 ,  A61N1/36021

Abstract: A medical kit and method for treating an ailment, such as chronic pain is provided. The kit comprises first and second medical leads, e.g., stimulation leads. Each lead comprises an elongated body and at least one operative element. The first medical lead comprises a coupling mechanism, such as a slot, and the second medical lead comprises a complementary mechanism, such as a rail, that slidably engages the coupling mechanism of the first medical lead. The method may comprise delivering the first medical lead into a patient's body, e.g., into the epidural space of the patient, and delivering the second medical lead into the patient's body by sliding the complementary coupling mechanism of the second medical lead along the coupling mechanism of the first medical lead.

Abstract translation: 提供了用于治疗诸如慢性疼痛之类的疾病的医疗用具和方法。 该试剂盒包括第一和第二医疗引线，例如刺激引线。 每个引线包括细长主体和至少一个操作元件。 第一医疗引线包括诸如槽的联接机构，并且第二医疗引线包括可滑动地接合第一医疗引线的联接机构的互补机构，例如轨道。 该方法可以包括将第一医疗引线输送到患者体内，例如进入患者的硬膜外腔，并且通过沿第二医疗引线的联接机构滑动第二医疗引线的互补联接机构，将第二医疗引线输送到患者体内 第一个医疗领导。

公开(公告)号：US20050182388A1

公开(公告)日：2005-08-18

申请号：US11040018

申请日：2005-01-19

Applicant: Robert Garabedian ,  John Griego ,  Earl Bardsley ,  Dean Schaefer ,  Cang Dao ,  Steven Anderson

Inventor： Robert Garabedian ,  John Griego ,  Earl Bardsley ,  Dean Schaefer ,  Cang Dao ,  Steven Anderson

IPC: A61M25/00 ,  A61M25/16

CPC classification number: A61M25/005 ,  A61M25/0053

Abstract: An intravascular catheter that exhibits the combined features of superior flexibility, softness, radiopacity and oval/kink resistance. The catheter includes an elongate shaft having a proximal region, a distal region and a lumen extending therethrough. The proximal region of the shaft includes an inner lubricious polymer layer, a reinforcement layer and an outer layer. The reinforcement layer comprises a braid having one or more metallic members and a plurality of polymer members wherein each polymer member comprises a plurality of monofilaments, preferably formed of LCP. The polymer members of the braid provide improved flexibility and softness in addition to high burst pressure. The metallic member(s) of the braid provide improved radiopacity and oval/kink resistance. The catheter may also include a longitudinal member extending along the reinforcement layer.

公开(公告)号：US20050059852A1

公开(公告)日：2005-03-17

申请号：US10665110

申请日：2003-09-16

Applicant: Robert Rioux ,  Robert Garabedian

Inventor： Robert Rioux ,  Robert Garabedian

IPC: A61N1/40 ,  A61N2/02 ,  A61N2/08 ,  A61N2/00

CPC classification number: A61N1/406 ,  A61N2/02

Abstract: A system for treating tissue includes a source of conductive and/or magnetic beads, a first member, e.g., a catheter or cannula, coupled to the source of magnetic beads, and a second member, e.g., a catheter or cannula, carrying a magnet on its distal end. The system is used for ablating or otherwise treating tissue within a target tissue region including a blood vessel contacting or passing therethrough. Magnetic beads are introduced into the target tissue region, e.g., using the first member, and a magnetic field is generated within the target tissue region, e.g., using the second member, to cause the magnetic beads to migrate towards a wall of the vessel. Energy is delivered into the target tissue region, e.g., to heat tissue therein, and the magnetic beads may attenuate or enhance treatment of tissue adjacent to the vessel.

Abstract translation: 用于治疗组织的系统包括导电和/或磁珠的源，耦合到磁珠源的第一构件，例如导管或插管，以及携带磁体的第二构件，例如导管或套管 在它的远端。 该系统用于烧蚀或以其他方式处理包括接触或穿过其中的血管的靶组织区域内的组织。 将磁珠引入目标组织区域，例如使用第一构件，并且例如使用第二构件在目标组织区域内产生磁场，使磁珠朝向容器的壁迁移。 能量被递送到目标组织区域中，例如以加热其中的组织，并且磁珠可以减弱或增强对与血管相邻的组织的治疗。

公开(公告)号：US10278774B2

公开(公告)日：2019-05-07

申请号：US13051738

申请日：2011-03-18

Applicant: Michael P. Wallace ,  Robert Garabedian ,  David S. Utley ,  Brent C. Gerberding ,  John de Csepel

Inventor： Michael P. Wallace ,  Robert Garabedian ,  David S. Utley ,  Brent C. Gerberding ,  John de Csepel

IPC: A61B18/12 ,  A61B18/14 ,  A61B18/00 ,  A61N7/02 ,  A61B18/06 ,  A61B18/08 ,  A61B18/24 ,  A61B18/02 ,  A61B18/18

Abstract: In one embodiment, a device is provided including an expandable support member having a first portion and a second portion is provided. The first portion is adapted to have a smaller expansion index than the second portion. A therapeutic or diagnostic instrument is supported, at least in part, by the expandable support member first portion. In another embodiment, the support member is adapted for non-uniform expansion of the first and second portions. There are also described methods of forming therapeutic devices. There are also described methods of providing therapy to tissue in a body by positioning a device in proximity to tissue in a body selected to receive therapy. Next, the expandable support member second portion is expanded until the instrument is at a therapeutic position relative to the tissue in a body selected to receive therapy. Thereafter, therapy or diagnosis is provided to the selected tissue using the device.

公开(公告)号：US08845639B2

公开(公告)日：2014-09-30

申请号：US13007381

申请日：2011-01-14

Applicant: Michael P. Wallace ,  Robert Garabedian ,  Gregory P. Schmitz ,  Jeffery L. Bleich ,  Nestor C. Cantorna ,  Ronald Leguidleguid ,  Roy Leguidleguid ,  Michael Sheinberg

Inventor： Michael P. Wallace ,  Robert Garabedian ,  Gregory P. Schmitz ,  Jeffery L. Bleich ,  Nestor C. Cantorna ,  Ronald Leguidleguid ,  Roy Leguidleguid ,  Michael Sheinberg

IPC: A61B17/00 ,  A61B17/16 ,  A61B17/3207 ,  A61B17/14 ,  A61B19/00 ,  A61B17/32

CPC classification number: A61B17/1671 ,  A61B17/149 ,  A61B17/1659 ,  A61B17/320016 ,  A61B17/32002 ,  A61B17/3207 ,  A61B2017/00261 ,  A61B2017/320004 ,  A61B2017/320008 ,  A61B2017/32006 ,  A61B2017/32008 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B2090/3966

Abstract: Described herein are elongate devices for modifying tissue having a plurality of flexibly connected and rungs or links, and methods of using them, including methods of using them to decompress stenotic spinal tissue. These devices may be included as part of a system for modifying tissue. In general, these devices include a plurality of blades positioned on for formed from) rungs that are flexibly connected and may be separated by one or more spacers. The rungs are typically wider than they are long (e.g., rectangular). The rungs may be arranged, ladder like, and may be connected by a flexible connector substrate or between two or more cables. Different sized rungs may be used, or rungs with different cutting properties. In some variations the tissue modification devices may have a non-linear axial shape, or may be converted from a first axial shape to a second axial shape.

Abstract translation: 本文描述的是用于修改具有多个柔性连接和梯级或链节的组织的细长装置，以及使用它们的方法，包括使用它们来减压狭窄的脊髓组织的方法。 可以将这些装置作为用于修改组织的系统的一部分。 通常，这些装置包括多个叶片，其位于用于形成的梯级上，所述多个叶片被柔性地连接并且可被一个或多个间隔件隔开。 梯级通常比它们长（例如，矩形）宽。 梯级可以布置成梯子，并且可以通过柔性连接器基板或两根或更多根电缆连接。 可以使用不同尺寸的梯级，或者具有不同切割性能的梯级。 在一些变型中，组织改变装置可以具有非线性轴向形状，或者可以从第一轴向形状转换成第二轴向形状。

公开(公告)号：US08784338B2

公开(公告)日：2014-07-22

申请号：US12143404

申请日：2008-06-20

Applicant: Michael P. Wallace ,  Robert Garabedian ,  Brent C. Gerberding

Inventor： Michael P. Wallace ,  Robert Garabedian ,  Brent C. Gerberding

IPC: A61B5/00 ,  A61B5/103 ,  A61B5/107

CPC classification number: A61B18/18 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/1076 ,  A61B18/0218 ,  A61B18/082 ,  A61B18/14 ,  A61B18/1492 ,  A61B18/20 ,  A61B2018/00017 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00488 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00714 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2562/0257

Abstract: Methods and devices for measuring the size of a body lumen and a method for ablating tissue that uses the measurement to normalize delivery of ablational energy from an expandable operative element to a luminal target of varying circumference are provided. The method includes inserting into the lumen an expandable operative element having circuitry with resistivity or inductance that varies according to the circumference of the operative element, varying the expansion of the operative element with an expansion medium, measuring the resistivity of the circuitry, and relating the resistivity or inductance to a value for the circumference of the operative element. In some embodiments the sizing circuit includes a conductive elastomer wrapped around the operative element. Other embodiments of the method apply to operative elements that include an overlapping energy delivery element support in which the overlap varies inversely with respect to the state of expansion, and which is configured with sizing electrodes that sense the amount of the overlap.

Abstract translation: 提供了用于测量体腔尺寸的方法和装置以及用于消融组织的方法和装置，所述方法使用所述测量来将消融能量从可扩张的可操作元件的规则化转变为变化圆周的管腔靶。 该方法包括将具有电阻率或电感的电路的可扩展的操作元件插入到内腔中，所述电路或电感根据操作元件的周长而变化，用膨胀介质改变操作元件的膨胀，测量电路的电阻率， 电阻率或电感值为操作元件圆周的值。 在一些实施例中，施胶电路包括围绕操作元件缠绕的导电弹性体。 该方法的其他实施例适用于包括重叠的能量传递元件支撑件的操作元件，其中重叠相对于膨胀状态反向变化，并且其被配置有感测重叠量的尺寸电极。

公开(公告)号：US20130218153A1

公开(公告)日：2013-08-22

申请号：US13591991

申请日：2012-08-22

Applicant: Michael Wallace ,  David S. Utley ,  Brent Gerberding ,  Robert Garabedian

Inventor： Michael Wallace ,  David S. Utley ,  Brent Gerberding ,  Robert Garabedian

IPC: A61B18/00

CPC classification number: A61B18/00 ,  A61B17/00234 ,  A61B18/04 ,  A61B2017/320008 ,  A61B2017/320012

Abstract: An apparatus for treating tissue within a lumen may include a therapeutic or diagnostic instrument. A cleaning device may also be supported by the instrument. The cleaning device has a portion of a cleaning surface positioned proximal to the distal end of the cleaning device.

公开(公告)号：US20130150856A1

公开(公告)日：2013-06-13

申请号：US13757661

申请日：2013-02-01

Applicant: Ronnie I. MIMRAN ,  Amie R. BORGSTROM ,  Michael P. WALLACE ,  Robert GARABEDIAN ,  Roy LEGUIDLEGUID

Inventor： Ronnie I. MIMRAN ,  Amie R. BORGSTROM ,  Michael P. WALLACE ,  Robert GARABEDIAN ,  Roy LEGUIDLEGUID

IPC: A61B17/16

CPC classification number: A61B17/1671 ,  A61B5/4893 ,  A61B17/0218 ,  A61B17/025 ,  A61B17/1757 ,  A61B17/32 ,  A61B17/320016 ,  A61B17/7032 ,  A61B17/7062 ,  A61B17/864 ,  A61B2017/0046 ,  A61B2017/0256 ,  A61B2017/2212 ,  A61B2017/32006 ,  A61B2090/08021

Abstract: Devices and methods for cutting tissue in a patient. In some embodiments, a bimanually controlled device may include a tissue modification region; one or more (e.g., two) flexible elongate length of cable that extend proximally to distally, a tissue modification region along a portion of the length of cable; and a guidewire coupler at the distal end of the device for attaching the distal end of the tissue modification device to the proximal end of a guidewire. Method of using these devices (including devices having two or more parallel length of cutting regions) to cut tissue (e.g., spinal lamina) are also described.

Abstract translation: 用于切割患者组织的装置和方法。 在一些实施例中，双手控制的装置可以包括组织修改区域; 电缆的一个或多个（例如两个）柔性细长的长度向近端延伸，沿着电缆长度的一部分的组织修改区域; 以及在装置的远端处的导丝联接器，用于将组织改变装置的远端附接到导丝的近端。 还描述了使用这些装置（包括具有两个或更多个平行长度的切割区域的装置）切割组织（例如脊髓层）的方法。

公开(公告)号：US08398641B2

公开(公告)日：2013-03-19

申请号：US13338103

申请日：2011-12-27

Applicant: Michael P. Wallace ,  Robert Garabedian ,  Nestor C. Cantorna ,  Jeffery L. Bleich ,  Roy Leguidleguid ,  Ronald Leguidleguid

Inventor： Michael P. Wallace ,  Robert Garabedian ,  Nestor C. Cantorna ,  Jeffery L. Bleich ,  Roy Leguidleguid ,  Ronald Leguidleguid

IPC: A61B17/00

CPC classification number: A61B17/025 ,  A61B5/4893 ,  A61B17/0218 ,  A61B17/1671 ,  A61B17/32 ,  A61B17/320016 ,  A61B17/7032 ,  A61B17/7062 ,  A61B17/864 ,  A61B2017/0256 ,  A61B2017/32006

Abstract: Described herein are devices and methods for cutting tissue in a patient. In some embodiments, a bimanually controlled device may include a tissue modification region; at least two flexible elongate lengths of cable that extend substantially adjacent to each other proximally to distally; a plurality of rungs extending between the lengths of cable; and a pair of flexible elongate cutting members extending along the length of the tissue modification region of the device. Each elongate cutting member has a thickness cuts a discrete trough into tissue to a depth that is greater than the thickness of the cutting member. The device may further include a substrate sized and configured to releasably hold the cutting members a distance from one another and a pair of couplers positioned toward an outer edge region of the substrate and configured to releasably secure a cutting member to the outer edge region of the substrate.

Abstract translation: 本文描述了用于在患者体内切割组织的装置和方法。 在一些实施例中，双手控制的装置可以包括组织修改区域; 至少两个柔性长度的电缆，其基本上彼此相邻地向远侧延伸延伸; 在电缆长度之间延伸的多个梯级; 以及沿设备的组织修改区域的长度延伸的一对柔性细长切割构件。 每个细长的切割构件具有将离散凹槽切割成组织的厚度，其厚度大于切割构件的厚度。 该装置还可以包括基板，其尺寸和构造为将切割构件可释放地保持彼此间隔一定距离;以及一对耦合器，其朝向基板的外边缘区域定位，并且构造成将切割构件可释放地固定到外部边缘区域 基质。

公开(公告)号：US08394102B2

公开(公告)日：2013-03-12

申请号：US12824043

申请日：2010-06-25

Applicant: Robert Garabedian ,  Amie R. Borgstrom ,  Gregory B. Arcenio ,  Ronald Leguidleguid ,  Michael P. Wallace ,  Bryan Knodel

Inventor： Robert Garabedian ,  Amie R. Borgstrom ,  Gregory B. Arcenio ,  Ronald Leguidleguid ,  Michael P. Wallace ,  Bryan Knodel

IPC: A61B17/70

CPC classification number: A61B17/00234 ,  A61B17/1659 ,  A61B17/1671 ,  A61B2017/00469 ,  A61B2017/320044

Abstract: Described herein are pullwire handle devices for securing to a tissue-penetrating pullwire. In some embodiments, the device includes a handle body, a pullwire lock configured to removably lock the pullwire handle device onto a pullwire within the handle body, and a tip containment element configured to retain the distal tip of the pullwire. In some embodiments, the handle body further comprises a storage chamber configured to store a distal portion of the pullwire. Also described herein are methods for capturing a pullwire using a pullwire handle device. In some embodiments, the method includes the steps of inserting the distal end of a pullwire into the pullwire handle device, advancing the pullwire further into the pullwire handle device while the distal portion of the pullwire is contained within the pullwire handle device, and locking the distal portion of the pullwire within the pullwire handle device.

Abstract translation: 这里描述的是拉丝手柄装置，用于固定到组织穿透的拉丝。 在一些实施例中，该装置包括手柄主体，拉线锁定，其被配置为将拉线手柄装置可移除地锁定到手柄主体内的拉线上，以及尖端容纳元件，其构造成保持拉线的远端。 在一些实施例中，手柄主体还包括被配置为存储拉丝的远端部分的储存室。 这里还描述了使用拉线手柄装置捕获拉线的方法。 在一些实施例中，该方法包括以下步骤：将拉线的远端插入拉线手柄装置中，将拉线进一步推入拉线手柄装置，同时拉线的远端部分包含在拉丝手柄装置内， 拉线手柄装置内的拉丝的远端部分。